Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations by Lin-jian Wang, Lin-jian Wang, Lin-jian Wang, Yangyang Wu, Yangyang Wu, Yangyang Wu, Sha Xie, Hongkai Lian, Hongkai Lian, Hongkai Lian

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Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation by Alexey Ferapontov, Anders Mellemkjær, Helen M. McGettrick, Thomas Vorup-Jensen, Tue W. Kragstrup, Kristian Juul-Madsen

“…Earlier work reported that the complexes include at least part of the CD11a or CD11b chains containing the intercellular adhesion molecule (ICAM)-1 binding domain, and that sCD18 is capable of quantitatively competing with the cell membrane-bound form for ICAM-1 binding. …”
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Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions by Wenhua Liu, Na Li, Dongsheng Tang, Lang Qin, Zhiqiang Zhu

“…Neuroimaging biomarkers (e.g., striatal PET-dopamine binding potential) predict intervention outcomes (AUC = 0.79). 3. …”
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Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis. by Sarah G Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M Exley, Elisa Ramos-Sevillano, Douglas F Browning, Vasiliki Kostiou, Odile B Harrison, Holly B Bratcher, Gabriele Varani, Christoph M Tang, Daniel J Wilson, Martin C J Maiden

“…Many invasive bacterial diseases are caused by organisms that are ordinarily harmless components of the human microbiome. Effective interventions against these microbes require an understanding of the processes whereby symbiotic or commensal relationships transition into pathology. …”
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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4. by Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

“…Eight antibodies belonging to two clonal families, ITS102 and ITS103, which target unique epitopes in the CD4 binding site (CD4bs) region, were found to be broadly neutralizing and together neutralized all SIV strains tested. …”
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Effect of liposome binding antisense oligonucleotide BP1003 on albumin-bound paclitaxel sensitivity in pancreatic cancer cells by inhibiting STAT3 by FU Hua, ZHOU Guochao, CAI Rongmin, SONG Xin, YANG Dinghua

“…They were divided into control group (without drugs), BP1003 group (200 μg/mL BP1003 intervention), different concentrations of albumin-bound paclitaxel group (5, 10, 20 nmol/L albumin-bound paclitaxel intervention), BP1003+different concentrations of albumin-bound paclitaxel group (200 μg/mL BP1003 combined with 5, 10, 20 nmol/L albumin-bound paclitaxel intervention). …”
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Alternative cleavage and polyadenylation: key regulatory mechanisms in health and disease by Ying Zhang, Zikun Huang, Weiqing Lu, Zhaoyong Liu

“…Clinically, targeting APA regulatory mechanisms offers promising opportunities for therapeutic interventions and the development of personalized medical strategies. …”
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Modern Antiplatelet Therapy for Percutaneous Coronary Intervention. How to Make the Right Choice? by T. M. Uskach, A. S. Tereshchenko

“…The latest ESC guidelines on non-ST elevation ACS (2020) [1] demonstrate the possible preference for prasugrel in patients with ACS without ST-segment elevation undergoing percutaneous coronary intervention. Current article demonstrates the results of recent clinical studies and the real clinical data regarding antiplatelet therapy in patients with coronary interventions. …”
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Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

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Effectiveness of dietary interventions on metabolic and hormonal profiles in women with polycystic ovary syndrome by Mamta Gupta, Anuradha Yadav

“…Hormonal profiles also improved significantly, with reductions in LH, insulin, dehydroepiandrosterone, estradiol, prolactin, and testosterone, and increases in sex hormone binding globulin and progesterone. Conclusions: The findings indicate that structured dietary interventions are effective in improving both metabolic and hormonal parameters in women with PCOS. …”
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions by Ping Jin, Xirui Duan, Zhao Huang, Yuan Dong, Jianmei Zhu, Huiming Guo, Hui Tian, Cheng-Gang Zou, Ke Xie

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Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…Evidence certainty for many interventions was low, highlighting the need for higher-quality studies. …”
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A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2 by Sean Nolan, Marissa Vignali, Mark Klinger, Jennifer N. Dines, Ian M. Kaplan, Emily Svejnoha, Tracy Craft, Katie Boland, Mitchell W. Pesesky, Rachel M. Gittelman, Thomas M. Snyder, Christopher J. Gooley, Simona Semprini, Claudio Cerchione, Fabio Nicolini, Massimiliano Mazza, Ottavia M. Delmonte, Kerry Dobbs, Gonzalo Carreño-Tarragona, Santiago Barrio, Vittorio Sambri, Giovanni Martinelli, Jason D. Goldman, Jason D. Goldman, James R. Heath, Luigi D. Notarangelo, Joaquin Martinez-Lopez, Bryan Howie, Jonathan M. Carlson, Harlan S. Robins

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IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention by Schumertl T, Lokau J, Garbers C

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Predictive values of urinary metalloproteinases-2 and insulin-like growth factor-binding protein 7 for contrast medium-induced acute kidney injury by Zou Xiao-biao, Bao Wei-wei, Huang Xiao-ying, Lu Chen, Chen Juan, Wang Zhi-qing, Huang Ming-fang

“…ObjectiveTo explore the expressions of tissue inhibitor of metalloproteinases-2 （TIMP-2） and insulin-like growth factor-binding protein 7 （IGFBP7） in renal tissue and urine after an injury of contrast medium （CM） and the prediction values of urinary TIMP-2 and IGFBP7 for contrast-induced acute kidney injury （CI-AKI） in patients with primary percutaneous coronary intervention （PPCI）.MethodsTwenty male Sprague-Dawley rats were divided randomly into two groups of CI-AKI （<italic>n</italic>=9） and control （<italic>n</italic>=11）. …”
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Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation by Onur Ozturk, Evren Kilinc, Batuhan Gorkem Irez, Emel Timucin

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Exploring CD169⁺ Macrophages as Key Targets for Vaccination and Therapeutic Interventions by Rianne G. Bouma, Aru Z. Wang, Joke M. M. den Haan

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A Critical Evaluation of Intervention Studies for Reducing Sexism and a Suggestion for a Classification by Nihan Selin Soylu Konak, İbrahim Mert Teközel

“…According to this classification model, intervention studies addressing sexism can be classified into four basic dimensions: (1) intervention to the process of perceiving a stimulus containing sex information; (2) intervention to (implicitly or explicitly) the process of binding sex information to traits; (3) intervention to (explicit, subtle or implicit) sexist attitudes; and (4) intervention to sexist behavior. …”
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Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways by Mingyu Zhang, Xiaoxiang Guan, Zheng Dong, Chenxu Yang, Chao Xiong, Wenzheng Cheng, Aijing Shang, Yaru Liu, Xiaofei Guo, Bowen Zhang, Bo Zhang, Saidi Jin, Wenyi Qi, Berezhnova Tatjana Alexandrovna, Yuan Jiang, Zhimin Du, Chaoqian Xu

“…Mechanistically, Zfp36 binds to the 3′ untranslated region (3′UTR) of Ythdc2 mRNA, facilitating its degradation. …”
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Prevalence and Risk Factors of Iron Deficiency Among Female Athletes in Sulaymaniyah District, Kurdistan Region of Iraq by Gaziza Hassan Marouf, Hisham Arif Getta, Ahmed Farhan Shallal, Aveen M. Raouf Abdulqader

“…The parameters included complete blood counts (CBC), serum ferritin, serum iron, total iron-binding capacity (TIBC), and unsaturated iron binding capacity (UIBC). …”
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