Ameliorative Effect of Lacticaseibacillus paracasei Combined with Aerobic Exercise on Obesity in Mice by ZHAO Hanyi, CAO Sijia, QI Jianing, BIAN Yanqing, ZHANG Jiaqi, GAO Yuqi, FENG Zhaoyang, SUN Wenjing, XUE Yuling, WANG Yanhong, PENG Liping

“…Results: Compared with obese mice, combined intervention with L. paracasei N1115 and aerobic exercise significantly reduced body mass (P < 0.05) and decreased fat accumulation by reducing the expression of sterol regulatory element binding protein-1 (SREBP-1)/fatty acid synthase. …”
Get full text

KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells by Xin Qi, Jiang Zhou, Pan Wang, Yunyan Li, Haoran Li, Yuwen Miao, XiaoQing Ma, Xiayan Luo, Zhiling Zhang, Yanling He, Wenyi Shen, Wenquan Zhao, Rutao Cui, Cang Li, Huiyong Zhu, Jiong Lyu

Get full text

LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency by Yan C, Li Y, Li X, Li Y, Zhang Y, Sun J, Ding Q, Zhao X, Li B

“…Subsequently, we performed quantitative qRT-PCR and RNA-binding protein immunoprecipitation (RIP) to assess lncRNA levels. …”
Get full text

Maternal concentrations of vitamin D metabolites in response to high-dose oral vitamin D during first trimester pregnancy: a randomized controlled trial by Inayah Syafitri, Rima Irwinda, Yudianto Budi Saroyo, Yuditiya Purwosunu, Noroyono Wibowo

“…Maternal blood samples were collected before and after four weeks of intervention to assess changes in serum concentrations of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), vitamin D binding protein (VDBP), and 24,25-dihydroxyvitamin D (24,25(OH)2D). …”
Get full text

A High-Throughput Biosensing Approach for Rapid Screening of Compounds Targeting the hNav1.1 Channel: Marine Toxins as a Case Study by Huijing Shen, Yuxia Cui, Shiyuan Liang, Shuang Zhou, Yingji Li, Yongning Wu, Junxian Song

Get full text

Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis by Wang L, Liang L, Qian J, Yu C, Shi Y, Yan X, Chen X

“…The function of hsa_circ_0007991 involves binding to miR-505-3p, which modulates the expression of calnexin (CANX), influencing the biological behaviors of HCC cells. …”
Get full text

Intestinal phages interact with bacteria and are involved in human diseases by Han Shuwen, Ding Kefeng

Get full text

Expression and clinical significance of NLRC5 in hepatocellular carcinoma by Xiangyu Ma, Shangkun Ning, Tong Sun, Mei Liu, Jibing Liu

Get full text

Aggravated Ulcerative Colitis via circNlgn-Mediated Suppression of Nuclear Actin Polymerization by William W. Du, Chi Zhou, Hui Yang, Shuoyang Wen, Yu Chen, Eric X. Chen, Xiuwei H. Yang, Feiya Li, Kevin Y. Du, Hui Yuan, Ting Ye, Javeria Qadir, Burton B. Yang

“…Nlgn173 undergoes translocation into cell nuclei, where it interacts with actin, impeding the binding of actin-related protein 2 and 3 (Arp2/3) complex to actin molecules. …”
Get full text

Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats by Xiaoyue Zhang, Qianda Yan, Yuanyuan Xiao, Xingyan Du, Xuehua Zhang, Didong Lou, Fang Peng, Daiyong Chen, Wenchao Tang

“…The results demonstrated that APS intervention significantly alleviated renal injury and oxidative stress induced by sodium fluoride (NaF) in rats. …”
Get full text

Pleiotropic Effects of PCSK9 Inhibitors on Cardio-Cerebrovascular Diseases by Zhenzhen Li, Lin Zhu, Yeqiong Xu, Yiting Zhang, Yukai Liu, Huiling Sun, Shuo Li, Meng Wang, Teng Jiang, Junshan Zhou, Qiwen Deng

“…PCSK9 inhibitors significantly reduce LDL-C levels by binding to the PCSK9 molecule and preventing its interaction with LDLRs. …”
Get full text

A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma by Xiang Guo, Xiang Guo, Xiang Guo, Congfang Guo, Dongxiao Li, Yuting Bai, Mureed Abbas, Mureed Abbas, Ruiwen Fan, Yiyan Zhao, Yiyan Zhao

“…HLA-E ligands expressed on the surface of malignant melanoma cells can facilitate immune evasion by binding to the NKG2A receptor complex on immune cells. …”
Get full text

Prospective evaluation of CYP19A1-mediated aromatase inhibitors for ER+ breast cancers by ultra-high performance liquid chromatography tandem mass spectrometry supported by in sili... by N.J. Gumede, K. Bisetty, L. Escuder-Gilabert, M.J. Medina-Hernandez, S. Sagrado

“…Aromatase inhibitors (AIs) are widely utilized in the management of breast cancer, and the CYP19A1 aromatase is acknowledged as a validated target for therapeutic intervention in estrogen receptor positive (ER+) breast cancer. …”
Get full text

Targeting oncogenic activation of FLT3/SREBP/FASN promotes the therapeutic effect of quizartinib involving disruption of mitochondrial phospholipids by Feng Yin, Jing Yang, Hao Luo, Tiantian Yu, Wenhua Lu, Mingyue Zhao, Hongli Du, Shijun Wen, Peng Huang, Yumin Hu

Get full text

Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life’s Essential 8 and Life’s Simple 7 Frameworks by Adrian Martuszewski, Patrycja Paluszkiewicz, Rafał Poręba, Paweł Gać

“…Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention as a novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation and cardiac remodeling. …”
Get full text

Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis by Lili Zhao, Zihan Wei, Yibin Wang, Wanrong Chen, Wenjing Zhang, Mengfei Xie, Hong Chen, Yiping Zhang, Haiyan Gao, Xiaobing Jiang, Xiaobing Jiang

“…Studies have found that lactic acid bacteria has the potential to eliminate pollutants from the body.MethodsIn this study, we investigated the capacity of Lactiplantibacillus plantarum ZP-6, a strain isolated from human feces with demonstrated in vitro microplastic-binding activity, to alleviate the physiological toxicity of polystyrene nanoplastics (PS-NPs) in healthy and colitic murine models. …”
Get full text

Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells by Xiaoqiang Wang, Chao Song, Daqian Zhou, Yongliang Mei, Weiye Cai, Rui Chen, Jiale Lv, Houyin Shi, Zongchao Liu

“…Western blot and PCR outcomes reveal escalated expression of apoptosis‐related proteins (IL‐1β, TNF‐α, and CASP3) in lipopolysaccharide‐treated NPCs, ameliorated by puerarin intervention. Molecular docking simulations demonstrate favorable binding properties of puerarin with apoptotic proteins, while flow cytometry analysis indicates its ability to diminish NPC apoptosis. …”
Get full text

Immunomodulatory agents and cell therapy for patients with type 1 diabetes by Melanie Rodacki, Karina Ribeiro Silva, Debora Batista Araujo, Joana R. Dantas, Maria Eduarda Nascimento Ramos, Lenita Zajdenverg, Leandra Santos Baptista

“…Teplizumab, a humanized monoclonal antibody that binds to CD3, was recently approved in the USA to delay Stage 3 T1D in individuals ≥ 8 years of age. …”
Get full text

Enriching the Mediterranean diet could nourish the brain more effectively by Pasquale Picone, Antonella Girgenti, Miriam Buttacavoli, Domenico Nuzzo

Get full text

Anti-drug vaccines as a harm reduction strategy: potential, limitations, and translational challenges by Laxit K. Bhatt

“…Main body Anti-drug vaccines stimulate the production of drug-specific antibodies that bind to psychoactive substances in the bloodstream, forming complexes too large to cross the blood–brain barrier. …”
Get full text