Exosomal miR-499a-5p from human umbilical cord mesenchymal stem cells attenuates liver fibrosis via targeting ETS1/GPX4-mediated ferroptosis in hepatic stellate cells by Zheng Wang, Mengqin Yuan, Lichao Yao, Zhiyu Xiong, Kai Dai, Pingji Liu, Ping Chen, Muhua Sun, Kan Shu, Yuchen Xia, Yingan Jiang

“…Overexpression of ETS1 in HSCs counteracted miR-499a-5p-induced ferroptosis, underscoring the pathway’s potential as a target for therapeutic intervention. Furthermore, molecular docking simulations further identified optimal ETS1-GPX4 binding sites. …”
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The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study by Laila Mohammadlo, Kaveh Rahimi, Masomeh Rezaie, Nasrin Soufizadeh, Fariba Seyedoshohadaei, Khaled Rahmani, Reza Bekhradi

“…The data was analyzed using SPSS statistical software.Results: After the intervention, the regulation of the menstrual cycle in the EPO group was different from that of the placebo group (p=0.04). …”
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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

“…However, there is currently no effective pharmacological intervention that can reverse body weight loss and improve physical performance in patients with cachexia. …”
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Impact of vitamin A on aged people’s cognition and Alzheimer’s disease progression in an animal model by Pengfei Li, Jingjing Xu, Yujie Guo, Xiaojun Ma, Xixiang Wang, Lu Liu, Yu Liu, Xiuwen Ren, Jiahao Li, Ying Wang, Liping Meng, Shaobo Zhou, Linhong Yuan

“…Population-based cross-sectional and animal diet intervention studies were conducted to analyze the association between VA nutritional status and cognitive function and the underlying mechanisms. …”
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Epigenetic study of the long-term effects of gulf War illness by B. C. Jones, J. P. O’Callaghan, D. G. Ashbrook, L. Lu, P. Prins, W. Zhao, K. Mozhui

“…These genes point to biochemical mechanisms that may be targets for therapeutic intervention.…”
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Structure-guided virtual screening reveals phytoconstituents as potent cathepsin B inhibitors: Implications for cancer, traumatic brain injury, and Alzheimer’s disease by Nageeb Hassan, Mohammad Furkan, Mohd Shahnawaz Khan, Azna Zuberi, Moyad Shahwan, Moyad Shahwan, Anas Shamsi

“…Cathepsin B (CathB) is a lysosomal cysteine protease involved in various pathological and physiological processes and is becoming an attractive target for drug intervention in complex diseases like cancer, traumatic brain injury (TBI) and Alzheimer’s disease (AD). …”
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4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…Protein kinases are integral to AD pathology and represent promising targets for therapeutic intervention.MethodsA series of pyrimidine-based compounds 4-(4-(arylsulfonyl)piperazin-1-yl)-6-(thiophen-3-yl)pyrimidine derivatives (8-14) were synthesized and characterised. …”
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Cholesterol‐27α‐hydroxylase inhibitor nilvadipine can effectively treat cholestatic liver injury in adult offspring induced by prenatal dexamethasone exposure by Wen Hu, Jiayong Zhu, Qi Zhang, Xiaoqian Lu, Luting Yu, Bin Li, Liaobin Chen, Hui Wang

“…In vitro, dexamethasone activates glucocorticoid receptors, binding to the CYP27A1 promoter, and promotes its transcriptional expression. …”
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Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy by Shiwani Randhawa, Trilok Chand Saini, Manik Bathla, Rahul Bhardwaj, Rubina Dhiman, Amitabha Acharya

“…This review provides an in-depth analysis of various nanochaperones developed to target AβOs, detailing their mechanisms of action and therapeutic potential via focusing on two main strategies, namely, disruption of AβOs through direct interaction and the inhibition of AβO nucleation by binding to intermediates of the oligomerization process. …”
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Multi-Omics and Experimental Validation Identify GPX7 and Glutathione-Associated Oxidative Stress as Potential Biomarkers in Ischemic Stroke by Tianzhi Li, Sijie Zhang, Jinshan He, Hongyan Li, Jingsong Kang

“…The correlation between this gene and immune cell infiltration was assessed using MCPcounter and a potential therapeutic agent, glutathione, was identified. Binding was verified by molecular docking (MD) analysis. …”
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The Effects of Cinnamon on Metabolic and Hormonal Status of Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial by Sanam Hadipour, Leila Amini, Bahare Afshar, Afsaneh Ghasemi, Hamid Haghani, Homa Sadeghi Avval Shahr, Shayesteh Jahanfar

“…Before and 12 weeks after starting the intervention, blood tests were performed to measure fasting blood sugar (FBS), fasting insulin (FI), triglycerides (TG), total cholesterol, low-density lipoprotein, high-density lipoprotein, total testosterone (TT), and sex hormone binding globulin (SHBG). …”
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Polyzwitterionic hydrogel using waste biomass as solar absorbent for efficient evaporation in high salinity brine by Wenzong Liu, Sihui Wang, Zhenglin Chen, Jiaqi Yang, Zhiling Li, Aijie Wang

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Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children. by Anders Kämpe, Maria Enlund-Cerullo, Saara Valkama, Elisa Holmlund-Suila, Jenni Rosendahl, Helena Hauta-Alus, Minna Pekkinen, Sture Andersson, Outi Mäkitie

“…For 25(OH)D, two strong GWA signals were identified, localizing to GC (Vitamin D binding protein) and CYP2R1 (Vitamin D 25-hydroxylase) genes. …”
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Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Tr... by Xiaowen Wang, Kaiyun Yan, Cuifeng Wen, Jiaqi Wang

“…One hundred and eleven patients with CHF were allocated to the control group (CNG) (n=55) and intervention group (IG) (n=56) using the random number table method. …”
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Exploring the key ingredients and mechanisms of Banxia Xiexin decoction for the treatment of polycystic ovary syndrome based on network pharmacology and experimental validation by Bai Hai, Yingying Zhang, Jing Huang, Richard Mprah, Mingming Wang

“…Further analysis indicated that quercetin, glycyrrhetinic acid A and naringenin are the three key ingredients of BXD, and they have superior binding effects on the hub genes. Animal experiments demonstrated that BXD and its three key ingredients significantly ameliorated the PCOS symptoms, oxidative stress-related indicators and the expression of hub genes.Conclusions Five oxidative stress-related hub targets of BXD for PCOS were identified, including FOS, JUN, MAPK3, TP53 and HSP90AA1, while three key ingredients of BXD, quercetin, glycyrrhetinic acid A and naringenin, were uncovered.…”
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Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer by Teng Wang, Zhaoming Chen, Wang Wang, Wang Wang, Heng Wang, Shenglong Li

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FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists. by Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss

“…<h4>Results</h4>The variant CFP/YFP-receptor chimera expressed predominantly at the plasma membrane of HEK293 cells and displayed ligand-binding affinities comparable with those of the wild-type receptor. …”
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The prevalence of hypogonadism in men with type 2 diabetes mellitus in clinical practice by Galina A. Melnichenko, Marina V. Shestakova, Roman V. Rozhivanov

“…Assessments included total testosterone, luteinizing hormone (LH), sex hormone-binding globulin, HbA1c levels. Levels of free testosterone were calculated by Vermeullen method. …”
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Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms. by Gareth J Staton, Simon R Clegg, Stuart Ainsworth, Stuart Armstrong, Stuart D Carter, Alan D Radford, Alistair Darby, Jonathan Wastling, Neil Hall, Nicholas J Evans

“…This work has shed light on treponeme host adaptation and has identified candidate molecules for future diagnostics, vaccination and therapeutic intervention.…”
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The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells by Jianguo Zhang, Yanhui Liu, Hailong Zhang, Lin Yang, Danjing Sun, Lili Xiao, Xiaoyun Wang, Xiangming Wu

“…This study investigates the role of E2F1 in regulating EIF4EBP1 expression and its contribution to excessive autophagy and apoptosis in cryptorchidism.MethodsA cryptorchidism mouse model was established through surgical intervention, while an in vitro cryptorchid spermatogonial cell model was created using heat stress. …”
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