Targeting CD44 and EpCAM with Antibody Dye Conjugates for the Photoimmunotherapy of Prostate Cancer by Isis Wolf, Susanne Schultze-Seemann, Christian Gratzke, Philipp Wolf

“…Results: The anti-CD44 and anti-EpCAM antibody dye conjugates showed specific binding and high cytotoxicity against PC and PCSC-like cells following irradiation with red light. …”
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Do Pediatric Nephrologists Know Their Educational Competencies? by Seçil Arslansoyu Çamlar, Hatice Şahin

“…Conclusion: It was found that the level of knowledge of pediatric nephrologists about specialty competencies differed in terms of some variables and knowledge was more limited in young learners for whom competencies are legally binding. In conclusion, it is recommended that learners should be informed about the competencies at the beginning of specialty training and participate in updating the competency list.…”
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In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. by Baback Roshanravan, Sophia Z Liu, Amir S Ali, Eric G Shankland, Chessa Goss, John K Amory, H Thomas Robertson, David J Marcinek, Kevin E Conley

“…This response represents the first demonstration of a pharmacological intervention that can reverse mitochondrial dysfunction in vivo immediately after treatment in aging human muscle.…”
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. by Ariel Shepley-McTaggart, Cari A Sagum, Isabela Oliva, Elizabeth Rybakovsky, Katie DiGuilio, Jingjing Liang, Mark T Bedford, Joel Cassel, Marius Sudol, James M Mullin, Ronald N Harty

“…The extreme C-terminal (ECT) sequence of E also contains a putative PDZ-domain binding motif (PBM), similar to that identified in the E protein of SARS-CoV-1. …”
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Anti-cancer effects of F16: A novel vascular endothelial growth factor receptor–specific inhibitor by Appu Rathinavelu, Khalid Alhazzani, Sivanesan Dhandayuthapani, Thanigaivelan Kanagasabai

“…Vascular endothelial growth factor receptor-2 is a dynamic target for therapeutic intervention in various types of cancers. This study was aimed to explore the anti-angiogenic activity of a novel vascular endothelial growth factor receptor–specific inhibitor named F16 in both in vitro and in vivo experimental models. …”
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Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses. by Janet Sultana, Marco Calabró, Ricard Garcia-Serna, Carmen Ferrajolo, Concetta Crisafulli, Jordi Mestres, Gianluca Trifirò'

“…All studies had to be in English and had to concern AP use as an intervention in persons of any age and for any indication, provided that the outcome was pneumonia. …”
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S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10. by Weiping Qin, Lap Ho, Jun Wang, Elaine Peskind, Giulio Maria Pasinetti

“…Using surface-enhanced laser desorption ionization-mass spectrometry SELDI-(MS) proteomic technology, we identified and purified a novel 11.7-kDa metal- binding protein biomarker whose content is increased in the cerebrospinal fluid (CSF) and in the brain of AD dementia subjects as a function of clinical dementia. …”
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Long-term cardiometabolic and bone health consequences of ketogenic diet in children with refractory epilepsy by Wael A. Bahbah, Ali M. El-Shafie, Heba M. S. El Zefzaf, Doaa M. Hosny, Shymaa A. Elshafey, Aya A. A. Hegazy

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Effectiveness and its mechanism of chrysophanic acid for aortic calcification with diabetic nephropathy based on the Notch1-RBP-Jk/Msx2 signaling pathway by DUAN Xiao-xing, CHANG Yong-li, ZHANG Guo-guang, PAN Xue

“…Renal function changes before and after intervention were compared. After intervention, the rats in each group were sacrificed, and the abdominal aorta was taken to observe the calcification. …”
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Critique in, for, with, and of responsible innovation by Mareike Smolka, Tess Doezema, Lucien von Schomberg

“…R(R)I promises to critique dominant technocratic and economic regimes by conducting critical analysis, promoting critical reflection, and launching critical interventions to democratize science, technology, and innovation. …”
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Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses by Xiaolong Li, Cheng-hao Yang, Min Zhou, Min-yi Yin

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By modulating miR‐525‐5p/Bax axis, LINC00659 promotes vascular endothelial cell apoptosis by Xizheng Zhu, Beijia Chen, Hui Xu

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Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans by Yann Bachelot, Anastasia Solomatina, Marc Thilo Figge

“…To achieve CME, we hypothesize that the pathogen secretes defense molecules that bind AMP. When bound within the complex, AMP are unable to harm the pathogen. …”
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Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics by Xun Huang, Yunhong Wang, Rong Wan, Zhigang You, Lin Huang

“…Differential expression analysis of model vs. control and intervention vs. model samples was performed to obtain differentially expressed genes (DEGs), and the result was recorded as DEGs-Model and DEGs-Intervention. …”
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Multi-omics analysis of the anti-cancer effects of curcumol in endometrial carcinoma by Jumin Xie, Ying Zhu, Haozhen Bai, Zean Song, Shukai Qiu, Youyi Xie, Shuqiong Wan

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Decoding Cold Therapy Mechanisms of Enhanced Bone Repair through Sensory Receptors and Molecular Pathways by Matthew Zakaria, Justin Matta, Yazan Honjol, Drew Schupbach, Fackson Mwale, Edward Harvey, Geraldine Merle

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Investigating the Effects of Gossypetin on Liver Health in Diet-Induced Pre-Diabetic Male Sprague Dawley Rats by Karishma Naidoo, Andile Khathi

“…The findings of this study may suggest that GTIN and MET exhibit therapeutic effects on liver health in diet-induced pre-diabetes in both the presence and absence of diet intervention. Dietary intervention may confer beneficial effects on liver health, with the most favorable therapeutic outcomes observed through a combination of treatment with dietary intervention. …”
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24-Week jumping exercise influence on growth speed and GH-IGF-1-IGFBP-3 axis among short-stature children by Huiming Wang, Xing Wang, Xiang Wang, Xin Xin, Hui Zhang, Shuqi Jia, Wenyuan Wang

“…Methods A non-randomized controlled intervention study was registered on January 8, 2025, with the China Clinical Trial Registry (ChiCTR2500095544). …”
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Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration by Ao Zhang, Ting-Ting Wei, Honglin Yin, Cheng-Ye Tan, Cheng Han, Yong Yao, Lingpeng Zhu

“…In this study, we found that Z-DNA binding protein 1 (ZBP1), a sensor for dsDNA, is able to induce RPE cell PANoptosis. …”
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Exploring the Mechanism Underlying the Protective Effect of Mulberry Leaf Flavonoid Extract on a Cellular Model of Diabetic Encephalopathy Using Network Pharmacology by XU Han, LI Liang, CHAI Tao, DU Hongyan, LI Xueli, JIANG Yan

“…Cell viability, oxidative damage indexes, apoptosis rate, and advanced glycation end products (AGEs) content were determined after 48 h intervention with MFE. Key targets and pathways for MFE intervention in DE were selected by network pharmacology, and molecular docking of the major components of MFE to the key targets was performed. …”
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