LncRNA H19 promotes adipogenic differentiation disorder by sponging miR-130b-3p to upregulate PPARγ in steroid-induced osteonecrosis of the femoral head by Feifei Lin, Min Yi, Shicheng Zhou, Qingyu Wang

“…This study provides critical insights into the epigenetic regulation of BMSC lineage commitment in SONFH pathogenesis, offering new avenues for intervention.…”
Get full text

Corresponding of Genetic polymorphism the apolipoprotein B R3500Q gene mutation with possible Familial Hypercholesterolemia (FH) pateints in Sulaymaniyah by Hadeel A. Abdel-Razaak Al-daraji, Akeel H. Ali Al-Assie, Rada H. Hussien

“…The current study aimed to identify mutations in people with homozygous genotypes that affect protein binding causing defects and to ensure that these conditions are diagnosed through important molecular tests through the early intervention of the apoptoprotein gene (apoB) for the R3500Q mutagenic of healthy individuals not associated with hypercholesterolemia (FH) in Sulaymaniyah through the conduct of the polymer chain reaction system and Restrication enzyme genotyping. …”
Get full text

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration by Ekaterina Grebenik, Sofia Zaichick, Gabriela Caraveo

“…These findings suggest that FK506’s neuroprotective effects may be partially mediated through GAP-43 phosphorylation, providing a potential target for therapeutic intervention in synucleinopathies.…”
Get full text

Treatment of pemphigus and other neglected skin conditions with PC111, a human anti-Fas Ligand monoclonal antibody: a potential disease modifier by Roberta Lotti, Antonino Amato, Brydon Bennett, Tommaso Zanocco-Marani, Alessandra Marconi, Carlo Pincelli

“…Its fast action suggests potential for early intervention to halt disease progression.Conclusions PC111 may act as a disease-modifying agent, promoting long-term remission in PV and preventing progression in early-stage SJS/TEN.…”
Get full text

CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1 by Rui Wang, Fei Wang

“…Luciferase reporter assay was executed to check the binding relationship between these genes. Cell function tests were conducted using CCK-8, would healing, and flow cytometry. …”
Get full text

Targeting m6A methylation for early diagnosis and precision medicine in hepatocellular carcinoma by Qing-Kang Zheng, Ya-Nan Shi, Ming-Yuan Yang, Yi-Yuan Xie, Kai Sun, Huan-Zhang Niu

Get full text

Effect of docetaxel administration on fluid dynamics in mice by Ayana Mawaki, Masushi Kohta, Aya Yoshimura, Toshio Nakatani, Shizuko Nagao, Junko Sugama

“…Results: The Miles assay with Evans Blue, an albumin-binding dye, revealed that leakage of blood plasma was significantly increased in the control group compared with the intervention group (p<0.01). …”
Get full text

CD1d facilitates African swine fever virus entry into the host cells via clathrin-mediated endocytosis by Xin Chen, Jun Zheng, Chuanxia Liu, Tingting Li, Xiao Wang, Xuewen Li, Miaofei Bao, Jiangnan Li, Li Huang, Zhaoxia Zhang, Zhigao Bu, Changjiang Weng

“…Using IP-MS assay, CD1d was identified as a binding partner of p72 on surface of ASFV virions. …”
Get full text

Tess of the d’Urbervilles du roman à l’écran : les ambiguïtés du point de vue by Isabelle Gadoin

“…This article tries to study some of the means of rendering this ambiguity on the screen, by various processes of « subjective images », but also points the limits of such adaptations : what the film seems to erase is the double-bind subtly created in the novel by the split between focalisation and narrative intervention. …”
Get full text

Beyond a Single Marker: An Update on the Comprehensive Evaluation of Right Ventricular Dysfunction in Pulmonary Thromboembolism by Sandu Cucută, Minerva Codruta Badescu, Ștefania-Teodora Duca, Adriana Chetran, Maria-Ruxandra Cepoi, Cosmina-Georgiana Ponor, Amelian Madalin Bobu, Ionela-Lacramioara Serban, Irina-Iuliana Costache-Enache

“…Understanding the role of biomarkers in RV dysfunction assessment may improve patient outcomes focusing on early intervention and personalized treatment approaches.…”
Get full text

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents by Zhongyu Zhang, Zhengde Zhao, Xiuyi Huang, Lifang Zhou, Xin Jiang, Haoliang Wu, Chenshu Liu, Kan Huang, Jielu Wen, Yunchong Liu, Michelle C. Miller, Zihan Zhao, Zhen He, Yuxin Wang, Siyu Liu, Lijin Huang, Lining Yuan, Renli Zeng, Zhipeng Cen, Anning Chen, Yanbo Chen, Gang Zeng, Wenzhou Liu, Xiaosi Hong, Meng Ren, Li Yan, Yang Zhang, Dongxian Guan, Xiaoyu Tian, Weikang Cai, Guihua Tai, Kevin H. Mayo, Yifa Zhou, Zilun Li, Sifan Chen

Get full text

Reading of human acute immune dynamics in omicron SARS-CoV-2 breakthrough infection by Haibo Li, Hongyu Liu, Hongping Wu, Chang Guo, Wenting Zuo, Ying Zheng, Xiaoyan Deng, Jiuyang Xu, Yeming Wang, Zai Wang, Binghuai Lu, Baidong Hou, Bin Cao

Get full text

The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity by Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou

“…Our study suggests that the IPA‐based gut‐brain axis regulates host metabolism, and supplementation with microbiome‐derived IPA could be a promising intervention strategy for treating obesity.…”
Get full text

<i>Moringa oleifera</i> Supplementation as a Natural Galactagogue: A Systematic Review on Its Role in Supporting Milk Volume and Prolactin Levels by Mohammad Ammar, Giovanni Luca Russo, Almothana Altamimi, Mohammad Altamimi, Mohammed Sabbah, Asmaa Al-Asmar, Rossella Di Monaco

“…Eight studies met the inclusion criteria, with intervention durations ranged from 3 to 10 days. <i>Moringa</i> supplementation increased significantly breast milk volume by up to 400 mL/day compared to controls. …”
Get full text

Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer by Zhi Lin, Chonglei Zhong, Ming Shi, Qinpeng Long, Liang Jing, Yang Yu, Jing Chou, Miao Chen, Minhuan Lan, Fei Long

“…CircTFRC emerges as a biomarker with diagnostic potential and a candidate for therapeutic intervention targeting ferroptosis in GC.…”
Get full text

Exploring the molecular mechanisms of subarachnoid hemorrhage and potential therapeutic targets: insights from bioinformatics and drug prediction by Yi Liu, Yang Zhang, Huan Wei, Li Wang, Lishang Liao

“…In conclusion, our findings not only elucidate the molecular mechanisms underlying SAH but also provide robust bioinformatics and experimental evidence supporting IRN as a promising therapeutic candidate, offering novel insights for future intervention strategies in SAH.…”
Get full text

Developmental riboflavin deficiency results in structural and functional changes in the neural retina and RPE by Xue Zhao, Mustafa S. Makia, Muna I. Naash, Muayyad R. Al-Ubaidi

“…Our previous research demonstrated that ablation of RTBDN, a retina-specific riboflavin binding protein, plays a pivotal role in maintaining flavin levels, leading to progressive retinal degeneration. …”
Get full text

IGF2BP3‐dependent N6‐methyladenosine modification of USP49 promotes carboplatin resistance in retinoblastoma by enhancing autophagy via regulating the stabilization of SIRT1 by Lei Li, Ning Yang, Jian‐Hong Sun, Li‐Juan Wei, Yuan Gao

“…In addition, we identified insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3)‐mediated N6‐methyladenosine (m6A) modification of USP49 as a regulatory mechanism, wherein IGF2BP3 upregulated USP49 expression in an m6A‐dependent manner. …”
Get full text

Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types by Gayathri Ashok, Abdullah F. AlAsmari, Fawaz AlAsmari, Paul Livingstone, Anand Anbarasu, Sudha Ramaiah

“…The tumor-specific expression and its critical overall survival suggest the inhibitors of FAP for potential cancer therapeutic intervention and hindering tumor microenvironment-driven cancer progression.…”
Get full text

CD4+ T cell recognition of HIV-1 alternate reading frame proteins by Joel Sop, Tyler P. Beckey, Joel N. Blankson

“…Our data expand the known HIV immunopeptidome and suggest that ARFPs may serve as potential targets for immune-based interventions.…”
Get full text