Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1 by Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen, Melinda M. Diver

“…Together, these findings advance our understanding of XPR1 transport activity and expand opportunities for rationalizing disease mechanisms and therapeutic intervention.…”
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Biomarkers of inflammation in sweat after myocardial infarction by Anna Björkenheim, Erik Sunnefeldt, Karl Finke, Daniel Robert Smith, Ole Fröbert, Noé Brasier

“…In this prospective study, we characterized the inflammatory signatures in plasma and sweat collected from the skin surface of two patient groups: (1) 18 STEMI patients immediately following percutaneous coronary intervention (exposure) and (2) six patients who underwent outpatient angiography without subsequent intervention (control). …”
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Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing by Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang

“…Key pathways enriched in angiosarcoma samples included growth factor binding, platelet-derived growth factor binding, and ribosome biogenesis, with abnormal expression of several ribosomal proteins. …”
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Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…TPL can enter RhoA, Rock1, and Rock2 target protein binding domains with stable binding activities, and may cause conformational changes of Rock1 related to molecular functions.ConclusionTPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.…”
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Integrative analysis identifies shared therapeutic pathways in thyroid eye disease and diabetes mellitus by Yifei Wang, Hui Li

“…Constructed mRNA-transcription factor, mRNA-RNA binding protein, mRNA-microRNA, and mRNA-drug interaction networks revealed extensive regulatory relationships. …”
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Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms by Jingyin Zhang, Zhuojun Li, Xiaoping Song, Panpan Cai, Qingchao Liu

“…Further transcriptomic and molecular docking studies suggested that ginsenoside CK may play an anti-photoaging role by binding to the active pocket of AKR1C1 and AKR1C2 proteins. …”
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Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants. by Mohibullah Shah, Sadia Pervaiz, Iqra Ahmad, Shahid Habib Ansari, Valdir Ferreira De Paula Junior, Sibtain Ahmed, Muhammed Umer Khan, Khaled Fahmi Fawy, Umar Nishan, Hanna Dib, Mohamed A O Abdelfattah

“…It involves the dysfunction of key enzymes such as Acetylcholinesterase (AChE) and β-secretase (BACE1), making them critical targets for therapeutic intervention. In this study we investigated an in-house library of 820 secondary metabolites obtained from Ayurvedic plants against AChE and BACE1 with the aim to discover novel leads for AD. …”
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Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy by Haodong He

“…TP53TG1 modulates gene expression by several mechanisms, including “competitive RNA” activity, competitive miRNA binding, control of critical signaling pathways, and facilitation of epigenetic changes. …”
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Genome-scale metabolic network reconstruction analysis identifies bacterial vaginosis-associated metabolic interactions by Lillian R. Dillard, Emma M. Glass, Glynis L. Kolling, Krystal Thomas-White, Fiorella Wever, Robert Markowitz, David Lyttle, Jason A. Papin

“…Through these analyses, we identify BV-associated bacteria that produce caffeate, a compound implicated in estrogen receptor binding, when grown in the spent media of other BV-associated bacteria. …”
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Role of the Psi Packaging Signal and Dimerization Initiation Sequence in the Organization of Rous Sarcoma Virus Gag-gRNA Co-Condensates by Gregory S. Lambert, Rebecca J. Kaddis Maldonado, Leslie J. Parent

“…These observations suggest additional, condensate-related roles for Gag-Ψ binding, gRNA dimerization, and Gag dimerization/multimerization in gRNA selection and packaging, representing a significant step forward in our understanding of how these interactions collectively facilitate efficient genome packaging.…”
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The efficacy of Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1 probiotics in modulating gut microbiota and reducing the risk of the characteristics of meta... by Wongsakorn Luangphiphat, Pinidphon Prombutara, Praewpannarai Jamjuree, Chantanapa Chantarangkul, Porntipha Vitheejongjaroen, Chantaluck Muennarong, Krittapat Fukfon, Manasvin Onwan, Malai Taweechotipatr

“…In the gut microbiome analysis, the results showed statistically significant differences in the beta diversity in the post-intervention probiotics group. Blautia, Roseburia, Collinsella, and Ruminococcus were among the gut microbiomes that were more prevalent in the post-intervention probiotics group. …”
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In vitro mechanistic studies and potential health benefits of a standardized bilberry extract in low mood and cognitive enhancement by Mehtap Kara, Gozde Hasbal-Celikok, Jacob Wilson, Pilar Gómez-Serranillos, Tugba Yilmaz-Ozden, Ezgi Öztas, Gul Özhan, Özge Sultan Zengin, Marta Sánchez Gómez-Serranillos, Claudia Owsianik, Fazle Rabbani, Merve Tunç, Nazlı Arda, Nazia M. Memon, Ikram Ujjan, Kenny Hawkins, Justine Davis, Gabriel Wilson, Giovanna Petrangolini, Amjad Khan, Amjad Khan

“…Enzyme inhibition assays targeted γ-Aminobutyric acid transaminase (GABA-T), monoamine oxidase A (MAO-A), and acetylcholinesterase (AChE), while GABAA receptor binding was also evaluated. Antioxidant capacity was assessed using DPPH, ABTS, FRAP, ORAC, HORAC, and TAS assays. …”
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ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation by Yan Rong, Yu‐Ke Wu, Yingyan Chen, Qing Liu, Leilei Ai, Yun‐Wen Wu, Yezhang Zhu, Yin‐Li Zhang, Chengkan Liu, Yerong Ma, Xiaomei Tong, Jiamin Jin, Xiaoxuan Li, Yan Zhou, Shu‐Yan Ji, Songying Zhang, Heng‐Yu Fan

“…Further, ZAR1/2 represents potential gene targets for diagnosis and clinical interventions in age‐associated deficiencies in oocyte and embryo development.…”
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Monobutyrin can alleviate hepatic lipid dysmetabolism and improve liver mitochondrial ultrastructure and autophagy in high-fat diet mice by Yuqing Zhang, Xiaoteng Li, Haidong Wang, Kexin Zhang, Ji Qiu, Minyao Zhou, Minqi Wang

“…These findings provide a novel insight into MB as an intervention strategy for hepatic metabolic disorders.…”
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CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis by Salemiz Sandoval, Martina Pigazzi, Kathleen M. Sakamoto

“…The cAMP response element-binding protein (CREB) is a nuclear transcription factor downstream of cell surface receptors and mitogens that is critical for normal and neoplastic hematopoiesis. …”
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West Nile Virus Vaccine Design by T Cell Epitope Selection: In Silico Analysis of Conservation, Functional Cross-Reactivity with the Human Genome, and Population Coverage by Frances M. Waller, Pedro A. Reche, Darren R. Flower

“…Vaccines represent the most efficacious and efficient medical intervention known. Epitope-based vaccines against WNV remain significantly underexploited. …”
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Neutrophil-Derived MRP14 Supports Plasma Cell Commitment and Protects Myeloma Cells from Apoptosis by Zhihong Zhao, Zhonghua Luo, Qian Yang, Hongbo Chang, Pengcheng Liu, Zhichao Li, Shengli Guo, Chunhui Zhou, Jian Song, Weidong Cao

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Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation. by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun

“…Vorinostat, originally an FDA-approved drug for cancer treatment, exhibited strong binding interactions with key TACE residues, suggesting its repurposing potential. …”
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Up-regulation of m6A writer METTL14 inhibits tumorigenesis by suppressing glycolysis in colorectal cancer by Lulu Li, Rong Zhang, Yongsheng Li

“…Meanwhile, ATF2 m6A level was significantly up-regulated by over-expression of METTL14, and the binding relationship between ATF2 and METTL14 was further verified. …”
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Ecological footprints, global sustainability, and the roles of natural resources, financial development, and economic growth. by Ali Hussein A L Marshadi, Muhammad Aslam, Azhar Ali Janjua

“…The EKC hypothesis remained undetermined for the estimated quantiles and geographical regions whereas it is established in high income group only. The policy intervention is recommended to restrict the natural resources depletion and binding the credit facilities to invest in ecosystem friendly projects by curtailing the process of ecological deficit for global sustainability which may be initiated from the most environment degraded quantiles, geographical region and income group.…”
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