RETRACTED ARTICLE: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p by Xiaoxiao Lu, Qingyun Zhu, Hong Du, Mingjun Gu, Xiangqi Li

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Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…Objective:To explore the mechanism of intervention of Hedyotis diffusa on osteosarcoma by network pharmacology and molecular docking.Methods:The active components and related targets of Hedyotis diffusa were predicted through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), while, osteosarcoma-related genes were obtained through Gene Expression Omnibus database. …”
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SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway by Junjie Li, Haixia Huang, Yifei Yin, Yizhu Mao, Mengxia Li, Hong Li, Chenxia Jiang, Rongxi Yang

“…Mechanistically, SERPINA1 activated the AKT/mTOR pathway via binding to MAPK6. Intervention targeting either SERPINA1 or MAPK6 has a significant impact on the malignancy of PTC cells. …”
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The Silent Threat of BPA: Its Pervasive Presence and Impact on Reproductive Health by Sanman Samova, Hetal Doctor

“…BPA has the ability to mimic estrogen and bind to estrogen receptors, which can lead to disruptions in hormonal signaling pathways. …”
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Separation of Powers and Climate Litigation: International Law as a Guide Between Judicial Activism and Legislative Prerogatives by Antonio Mariconda

“…Notably, a comparative analysis of domestic and international case law identifies three distinct approaches: strict deference to political institutions, moderate review, and active intervention, illustrating how different legal systems draw the boundary between law and politics in climate matters. …”
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Effect and Mechanism of Aloin in Ameliorating Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Network Pharmacology and Experimental Verification by Li R, Wang Y, Lao Y, You C, Qing L, Guan X, Wang J, Li X, Li Q, Liu S, Dong Z

“…The qRT-PCR results showed that Aloin intervention reduced the mRNA expression of AKT1, EGFR, HSP90AA1, and SRC, while increasing ESR1 mRNA expression. …”
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Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments by Yi Zhou, Shaoshuo Li, Bowen Hong, Zihan Wang, Yang Shao, Mao Wu, Mao Wu, Jianwei Wang, Jianwei Wang

“…Western blot analysis revealed that Iso treatment targeting the RANKL/RANK binding pathway significantly downregulated phosphorylation levels of JNK, P38, AKT, and p65. …”
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Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation by Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X

“…G. lucidum was involved in metabolic processes, such as lipid binding, insulin secretion, and other pathways. Molecular docking results showed that the core component β-sitosterol had strong binding activity with key targets CASP3, PRKACA, and PGR. …”
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Leptin and inflammatory pathways in the Alzheimer's disease continuum: Implications for glial activation and neuropsychiatric symptoms by Fumihiko Yasuno, Kazuyuki Nakagome, Yoshie Omachi, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, Kensaku Kasuga, Takeshi Ikeuchi, Akinori Takeda, Takashi Sakurai, Kengo Ito, Takashi Kato

“…Discussion: These findings underscore the relevance of exploring how leptin and adipose tissue dysfunction interact with neuroinflammatory processes in contributing to NPS in the patients in the AD continuum. Interventions targeting these interactions could represent promising avenues for managing NPS.…”
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Is Childhood IgA Nephropathy Different From Adult IgA Nephropathy? A Narrative Review by Areefa Alladin-Karan, Susan M. Samuel, Andrew W. Wade, Pietro Ravani, Silviu Grisaru, Ngan N. Lam, Kathryn A. Birnie, Robert R. Quinn

“…Children had more risk alleles for IgAN and higher levels of mannose-binding lectin than adults. Limitations: Most studies were retrospective and observational, with limited data on children and disease mechanisms. …”
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Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γSummary by Fang Wang, Claudia Rose Keating, Yingchen Xu, Wei Hou, Greg Malnassy, Kyle Boedeker, Aldeb Perera, Eugene Ham, Diya Patel, Xianzhong Ding, Wei Qiu

“…Background &amp; Aims: There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits our ability to provide targeted therapy interventions for HCC. In HCC samples, NAD-dependent deacetylase sirtuin 2 (SIRT2) levels are increased and associated with a significantly worse prognosis, but the role of SIRT2 in hepatocarcinogenesis remains controversial. …”
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AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

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Targeting B-raf/MEK signaling in melanocytic carcinoma using HPLC-MS/MS characterized metabolites from Valeriana wallichii Rhizome by Charushila V. Balikai, Raviraj M. Kulkarni, Kiran Thabaj, Shankar Gharge, Rohini S. Kavalapure, Shyam S. Desai

“…Molecular docking highlighted strong binding affinities of chlorogenic acid at the ATP-binding domains of both BRAF (CYS532, ASP594, LYS483, GLY534) and MEK (SER150, ALA95), with interaction energies comparable to reference inhibitors dabrafenib and DS03090629. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

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Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway by Yue Xu, Na Rentuya, Tianyuan Yu, Jiawang Yan, Hongzheng Zhang, Yingqi Zhang, Hanyu Zhang, Jiawei Sun, Jiayue Liu

“…The expression of Piezo1, Yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif (TAZ), Myelin basic protein (MBP), Neurofilament 200 (NF200), S100 calcium-binding protein β(S100β) and Ca2+ were detected using Immunofluorescence (IF), Western Blot (WB), Real-Time Quantitative PCR (RT-PCR) and Calcium Assay Kit. …”
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Use of idarucizumab for emergency surgery in patients taking dabigatran by O. M. Nesterova, Y. R. Lentsik, A. A. Vitik, E. D. Kosmacheva, V. I. Fetisova, M. N. Zamyatin

“…We describe two clinical situations, in which idarucizumab, a specific dabigatran antagonist, which is a monoclonal antibody fragment that binds dabigatran, was used to neutralize the anticoagulant effect of dabigatran etexilate before emergency surgery. …”
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Temporary 2-week suspension of methotrexate treatment to enhance COVID-19 vaccine response in people with immune-mediated inflammatory diseases: the VROOM RCT by Abhishek Abhishek, Nicholas Peckham, Corinna Pade, Joseph M Gibbons, Lucy Cureton, Catherine J Reynolds, Anne Francis, Vicki Barber, Jennifer Williams, Duncan Appelbe, Lucy Eldridge, Patrick Julier, Daniel M Altmann, James Bluett, Tim Brooks, Laura C Coates, Ines Rombach, Amanda Semper, Ashley Otter, Ana M Valdes, Jonathan S Nguyen-Van-Tam, Hywel C Williams, Rosemary J Boyton, Áine McKnight, Jonathan A Cook

“…Main outcome(s) and measure(s) The primary outcome was spike protein of the receptor binding domain antibody level 4 weeks after COVID-19 booster vaccination. …”
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A genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of Plasmodium falciparum. by Bharath Balu, Naresh Singh, Steven P Maher, John H Adams

“…Large-scale functional analysis of the parasite genome is essential to pave the way for novel therapeutic intervention strategies against the disease and yet difficulties in genetic manipulation of this deadly human malaria parasite have been a major hindrance for functional analysis of its genome. …”
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Reversal of sorafenib resistance in hepatocellular carcinoma by curcumol: insights from network pharmacology, molecular docking, and experimental validation by Ni Zhang, Xinchen Tian, Fen Liu, Xiaohan Jin, Xiaohan Jin, Jiaqi Zhang, Lingli Hao, Shulong Jiang, Shulong Jiang, Qingbin Liu, Qingbin Liu

“…Our findings suggest that curcumol holds promise as a novel therapeutic agent for overcoming drug resistance in HCC, offering a new avenue for clinical intervention.…”
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Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer by Zongming Dong, Xiaosa Chang, Xing Luo, Hui Li, Ming Deng, Zeyu Huang, Tingting Chen, Yu Chen, Bishao Sun, Yingbing Wu, Ronghua Wu, Qingjian Wu, Jingzhen Zhu, Ji Zheng

“…Molecular docking was used to analyze the binding between CH and its target protein. Additionally, quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blotting, gene knockout, pharmacological intervention, and tumor formation experiments were performed to validate the therapeutic effects and mechanisms of action of CH against PCa in vitro and in vivo. …”
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