Chorioamnionitis: clinical, anamnestic and molecular-genetic parallels by I. V. Ignatko, A. D. Megrabyan, V. M. Anokhina, A. A. Churganova, T. V. Rasskazova, O. V. Zavyalov, V. A. Titov, V. O. Petrova

“…We studied the polymorphism of genes FCGR2A (Fc fragment of immunoglobulin G receptor IIa), IFN-γ (interferon gamma), IL-10 (interleukin-10), IL-6 (interleukin-6) and MBL2 (mannose binding lectin 2) to determine their role in assessing a risk of maternal and neonatal infection.Results. …”
Get full text

Programmes québécois de lutte contre la violence scolaire : description, apports et limites by Gérald Boutin, Simon Forget

“…Devices set up to counter this plague vary of the simple warning in the massive, binding, even coercive intervention. Taking support on a documentation of first hands, the authors of this article review several programs of fight against the violence from Quebec area. …”
Get full text

Anti-lung Cancer Mechanism of Quercetin Based on Network Pharmacology and Experimental Validation by Yi WANG, Xiaofang PU

“…Molecular docking experiments preliminarily demonstrated strong binding affinity between quercetin and the three core targets. …”
Get full text

A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…<b>Background/Objectives:</b> Trastuzumab is an effective therapeutic intervention for treating HER2-positive breast cancers. …”
Get full text

Circular RNAs: biology and clinical significance of breast cancer by Zhanwei Wang, Hao Deng, Yao Jin, Meng Luo, Jia Huang, Jing Wang, Kun Zhang, Li Wang, Jiaojiao Zhou

Get full text

The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier by Dejiang Xue, Shuai Jiang, Miao Zhang, Kai Shan, René Lametsch, Chunbao Li

“…This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content, iron circulation, and liver homeostasis. …”
Get full text

Structure-based molecular screening and dynamic simulation of phytocompounds targeting VEGFR-2: a novel therapeutic approach for papillary thyroid carcinoma by Shuai Wang, Lingqian Zhang, Wenjun Zhang, Xiong Zeng, Jie Mei, Weidong Xiao, Lijie Yang

“…In this study, we employed virtual drug screening, molecular dynamics simulations, and binding free energy calculations to identify potential VEGFR-2 inhibitors from the African natural product database (AfroDb). …”
Get full text

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with... by Kathrin K Geyer, Umar H Niazi, David Duval, Céline Cosseau, Chad Tomlinson, Iain W Chalmers, Martin T Swain, David J Cutress, Utibe Bickham-Wright, Sabrina E Munshi, Christoph Grunau, Timothy P Yoshino, Karl F Hoffmann

“…Further deciphering the role of this epigenetic process during Biomphalaria/Schistosoma co-evolutionary biology may reveal key factors associated with disease transmission and, moreover, enable the discovery of novel lifecycle intervention strategies.…”
Get full text

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics by Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif, Declan G. Murphy

“…Our approach thus represents a future avenue for in vivo pharmacotranscriptomics that may guide the development of targeted pharmacotherapies and personalized interventions.…”
Get full text

Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis by Qijiao Wei, Jiayan Feng, Yifei Mu, Qian Shen, Hong Xu, Li Sun, Haimei Liu

“…Changes in molecular function were primarily associated with protein binding. Furthermore, six hub genes implicated in both diseases were linked to cell adhesion molecules. …”
Get full text

Changes in self-reported physical and mental health, behaviour and economic status among adults by known seropositivity and sociodemographic factors before and after the COVID-19 p... by Katie Bates, Katie Bates, Wegene Borena, Martin McKee, Lore Hayek, Paul Bouanchaud, Zoltán Bánki, Lydia Riepler, Annika Rössler, Annika Rössler, Barbara Falkensammer, Jörg Paetzold, Andreas Walser, Sebastian Schönherr, Lukas Forer, Ludwig Knabl, Ludwig Knabl, Janine Kimpel, Dorothee von Laer, Hanno Ulmer

“…The impacts of SARS-CoV-2 infections and non-pharmaceutical interventions required to reduce transmission were wide-ranging, including worsened mental and physical health and economic damage.MethodsWe analysed data from the Ischgl follow-up study. …”
Get full text

Prevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross-sectional study by Cristina Reverzani, Daniel Zaake, Faridah Nansubuga, Herman Ssempewo, Leonard Manirakiza, Anthony Kayiira, Gilbert Tumwine

“…We excluded pregnant women admitted to the hospital longer than 1 week before delivery; pregnant women with self-reported pre-existing kidney diseases, liver diseases, or gut or malabsorption disorders and pregnant women with severe pregnancy-unrelated comorbidities requiring intensive care unit admission before delivery.Interventions Maternal venous blood was collected at admission, and serum 25-hydroxy-vitamin D (25(OH)D) was measured by an electrochemiluminescence binding assay.Primary and secondary outcome measures Maternal sociodemographic characteristics and obstetric-medical factors, and adverse maternal and foetal outcomes were captured by using a data collection form. …”
Get full text

Expanding therapeutic horizons: glucagon-like peptide-1 receptor agonists and sodium glucose transporter-2 inhibitors in poly cystic ovarian syndrome: a comprehensive review includ... by Kannan Sridharan, Gowri Sivaramakrishnan

“…While lifestyle modifications are the cornerstone of PCOS management, pharmacological interventions, including metformin, oral contraceptives, and anti-androgens, are commonly utilized. …”
Get full text

Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis by Zimeng Ma, Zimeng Ma, Shuo Yan, Shuo Yan, Huimin Zhang, Huimin Zhang, Ruilin Du, Ruilin Du, Xinyue Cheng, Xinyue Cheng, Siqin Bao, Siqin Bao, Xihe Li, Xihe Li, Xihe Li, Yongli Song, Yongli Song

“…Notably, sodium octanoate exhibited potent anti-inflammatory effects through specific binding to ACSL4, a critical ferroptosis regulatory protein, this interaction ameliorated oxidative stress and inflammation cascades while demonstrating therapeutic potential for cadmium-induced inflammation.DiscussionOur findings establish the ACSL4/NF-κB axis as a central mechanism in cadmium-induced pathology, highlighting sodium octanoate as a potential therapeutic intervention for pollutant-induced intestinal disorders.…”
Get full text

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management by Ali Nabavi-Rad, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Sinéad Marian Smith, Mohammad Reza Zali

“…As Helicobacter pylori management has become more challenging and less efficient over the last decade, the interest in innovative interventions is growing by the day. Probiotic co-supplementation to antibiotic therapies is reported in several studies, presenting a moderate reduction in drug-related side effects and a promotion in positive treatment outcomes. …”
Get full text

Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer by Minhua Deng, Zhaohui Zhou, Jiawei Chen, Xiangdong Li, Zefu Liu, Jingwei Ye, Wensu Wei, Ning Wang, Yulu Peng, Xin Luo, Lijuan Jiang, Fangjian Zhou, Xianchong Zheng, Zhuowei Liu

“…Abstract Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. Elevated oxidative phosphorylation (OXPHOS) has been linked to cancer stemness, a determinant of chemoresistance. …”
Get full text

Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis by Xudong Xin, Xudong Xin, Xudong Xin, Xudong Xin, Haidong Zhou, Song Huang, Wenzhao Zhang, Jiahou Xu, Wei Wang, Jihua Wei, Jihua Wei, Jihua Wei, Jihua Wei, Liqing Li

“…Molecular docking studies revealed that quercetin exhibits a lower binding energy with the target protein binding site, forming a stable structure. …”
Get full text

Development of triaryl antimicrobials by scaffold hopping from an aminopropanol hit targeting bacterial RNA polymerase-NusG interactions by Tiankuang Liu, Cheuk Hei Kan, Yingbo Zheng, Tsz Fung Tsang, Yanpeng Liu, Man Wai Tsang, Hantian Fang, Long Yin Lam, Xiao Yang, Cong Ma

“…Bacterial RNA polymerase (RNAP) requires the NusG factor to facilitate transcription, with the RNAP clamp-helix domain (CH) serving as the primary binding site for NusG and representing a promising target for antimicrobial intervention. …”
Get full text

Proteomic analysis of premature umbilical cord blood and its relationship with bronchopulmonary dysplasia by Jia Chen, Yuanye He, Ying Liu, Zhiwei Guo, Longli Yan, Xiaotao Jiang, Weiwei Gao

“…Studies on plasma protein levels can facilitate early detection of BPD, enabling prompt intervention and a decrease in mortality. Methods We conducted a prospective observational study involving proteomic sequencing of plasma samples from 19 preterm infants. …”
Get full text

Exploring the efficacy of Benincasa hispida extract on obesity linked inflammatory bowel disease by integrating computational analysis and experimental validations by Santosh B. Patil, Manisha B. Kuvalekar, Deepak A. Yaraguppi, D. S. N. B. K. Prasanth, Sangameshwar G. Halkavatagi, Gururaj B. Tennalli, Mukhatar Ahmed Javali, T. M. Yunus Khan

“…Furthermore, the compounds were docked with the protein target via AutoDock 4.2, and the compound ajmalin exhibited the highest binding affinity with the MTOR protein, with a binding energy of -7.8 kcal/mol; later, a dynamic study was performed for the ajmaline and protein complex. …”
Get full text