Bind: large-scale biological interaction network discovery through knowledge graph-driven machine learning by Naafey Aamer, Muhammad Nabeel Asim, Aamer Iqbal Bhatti, Andreas Dengel

“…In a drug-phenotype interaction case study, BIND generated 1355 high confidence predictions, with novel interactions successfully validated through existing literature evidence. …”
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RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma by Yannan Geng, Lu Yang, Rui Shao, Tiantong Xu, Lilong Zhang

“…Abstract Background Our aim was to identify crucial RNA-binding proteins (RBP) genes associated with Ewing sarcoma (EwS) in order to provide valuable insights into its mechanisms of tumorigenesis and to enhance therapeutic intervention. …”
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Investigating interventions in Alzheimer's disease with computer simulation models. by Carole J Proctor, Delphine Boche, Douglas A Gray, James A R Nicoll

“…We previously developed a stochastic computer model to examine some of the key pathways involved in the aggregation of amyloid-beta (Aβ) and the micro-tubular binding protein tau. Here we show how we extended this model to include the main processes involved in passive and active immunisation against Aβ and then demonstrate the effects of this intervention on soluble Aβ, plaques, phosphorylated tau and tangles. …”
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miRNA interplay: Mechanisms and therapeutic interventions in cancer by Zehua Wang, Hangxuan Wang, Shuhan Zhou, Jiasheng Mao, Zhiqing Zhan, Shiwei Duan

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Naloxone in Buprenorphine Overdose: A Life Saving Intervention by Aviral Ratan Srivastava, Sarbari Swaika, Tanvi Snehal Desai

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In-feed provision of binding proteins sustains piglet gut health and mitigates ETEC-induced post-weaning diarrhea by Jiajia Xu, Melania Andrani, Rikke Brødsgaard Kjærup, Tina Sørensen Dalgaard, Carsten Eriksen, Andreas Hougaard Laustsen, Susanne Brix, Sandra Wingaard Thrane, Nuria Canibe

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Corticotrophin-releasing hormone binding protein in the basolateral amygdala: divergent roles in cocaine and opioid addiction like behaviors by Courtney P. Wood, Arnav Gurha, Caitlin Crook, Angelica Martinez, Selen Dirik, Cloe Moreno, Anirudh Vaiyapuri, Avraham Libster, Francesca Telese, Giordano de Guglielmo

“…Our findings position Crhbp as a potential therapeutic target gene for tailored interventions in cocaine and opioid SUDs.…”
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Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease by Qinqin Ouyang, Jiaqi Su, Yixuan Li, Haiping Liao, Haiying Guo, Yanan Sun, Xiaoyu Wang, Juan Chen, Josephine Thinwa, Wen-Xing Ding, Herbert Tilg, Fazheng Ren, Hao Zhang, Rong Liu

“…Our study found reduced levels of GTPase-activating protein-binding protein1 (G3BP1) in patients with MASLD and MASH, suggesting its involvement in these liver disorders. …”
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Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA by Che-Mai Chang, Chang-Jiun Wu, Maxim Shkurnikov, Chin-Lin Guo, Wan-Chen Huang, Alexander Tonevitsky, Wei-Chiao Chang

“…Results Our findings revealed that mutations in the Spike protein had a more pronounced effect on HLA class II binding affinities than on HLA class I. While binding affinity profiles for HLA class I were largely consistent across populations, significant population-specific variations were observed for HLA class II alleles. …”
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Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis by Takuya Murao, Gaifeng Ma, Atsushi Murao, Alok Jha, Jingsong Li, Yongchan Lee, Mian Zhou, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz

“…OP18 was developed by identifying a 15-amino acid (aa) binding site within the extracellular domain of Toll-like receptor 4 (TLR4) shared by eCIRP, HMGB1, and histone H3, then extending it with an αvβ3-integrin binding RGD (Arg-Gly-Asp) motif, resulting in an 18-aa peptide. …”
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The Prognostic Potential of Insulin-like Growth Factor-Binding Protein 1 for Cardiovascular Complications in Peripheral Artery Disease by Ben Li, Farah Shaikh, Houssam Younes, Batool Abuhalimeh, Abdelrahman Zamzam, Rawand Abdin, Mohammad Qadura

“…Of all proteins studied, only insulin-like growth factor-binding protein 1 (IGFBP-1) showed a significant elevation among patients who suffered MACE versus those who remained event-free (20.66 [SD 3.91] vs. 13.94 [SD 3.80] pg/mL; <i>p</i> = 0.012). …”
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Determination of the molecular basis for a limited dimorphism, N417K, in the Plasmodium vivax Duffy-binding protein. by Amy M McHenry, Samantha J Barnes, Francis B Ntumngia, Christopher L King, John H Adams

“…The P. vivax Duffy-binding protein (PvDBP) is heavily dependent on the interaction with the human Duffy blood group antigen/receptor for chemokines (DARC) for invasion. …”
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Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates by Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza, Greta Hultqvist

“…The ability of the multivalent antibodies to bind a wider range of αSyn aggregate species, which are not targetable by conventional bivalent antibodies, thus could allow for an earlier and more effective intervention in the progression of PD.…”
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Phage-Displayed Peptides Selected to Bind Envelope Glycoprotein Show Antiviral Activity against Dengue Virus Serotype 2 by Carolina de la Guardia, Mario Quijada, Ricardo Lleonart

“…Blind docking simulations were done to investigate the possible mode of binding, showing that all peptides appear to bind domain III of the protein and may be mostly stabilized by hydrophobic interactions. …”
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Terahertz Wave Alleviates Comorbidity Anxiety in Pain by Reducing the Binding Capacity of Nanostructured Glutamate Molecules to GluA2 by Zihua Song, Yuankun Sun, Pan Liu, Hao Ruan, Yuanyuan He, Junkai Yin, Chun Xiao, Jing Ma, Yun Yu, Shaomeng Wang, Yubin Gong, Z. W. Lin, Zhi Zhang, Chao Chang, Maojun Yang

“…The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy and carry a risk of side effects. …”
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Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS by Kaili Li, Zixiang Zhou, Feng Liu, Zuotian Huang, Xiaoying Chen, Fachun Zhou

“…In conclusion, AKBA treatment may be a potential strategy in the intervention of ARDS. Alternatively, BST2 may contribute to the anchoring of AKBA to HPMECs, and STAT1 as a transcription factor promoting BST2 expression may bind to its promoter.…”
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The feasibility of point-of-care testing for initial urinary liver fatty acid-binding protein to estimate severity in severe heatstroke by Shoji Yokobori, Junya Shimazaki, Hitoshi Kaneko, Hideki Asai, Jun Kanda, Shuhei Takauji, Eiichi Sato, Ryo Ichibayashi, Motoki Fujita, Shinichiro Shiraishi, Keiki Shimizu, Hiroyuki Yokota

“…Abstract Rapid assessment of severity is crucial for timely intervention and improved patient outcomes in heatstroke (HS). …”
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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Importantly, these findings establish a conceptual framework for lncRNA-driven interventions in skeletal disorders, highlighting the translational potential of targeting RNA-protein complexes to restore bone homeostasis.…”
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Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF by E. Riveland, A. Ushakova, T. Valborgland, T. Karlsen, H. Dalen, E. Prescott, T. Omland, A. Linke, M. Halle, M. Marber, Ø. Ellingsen, A.I. Larsen, the SMARTEX‐HF Study Group

“…As the training load in the two intervention arms was similar, these patients were merged and constituted the intervention group (IG). …”
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Involvement of dysregulated RNA binding protein and alternative splicing regulatory networks in diabetic nephropathy from type 2 albuminuric cohorts by Yu Wang, Jingjing Zhang, Qian Tang

“…This study aims to elucidate the role of RNA-binding proteins (RBPs) and RBP-alternative splicing (AS) regulatory networks in the pathogenesis of DN. …”
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