Comparative evaluation of in-house ELISA and two commercial serological assays for the detection of antibodies against SARS-CoV-2 by Dabesa Gobena, Esayas Kebede Gudina, Tizta Tilahun Degfie, Tsinuel Girma, Getu Gebre, Alemseged Abdissa, Fikadu G. Tafesse, Tesfaye Gelanew, Zeleke Mekonnen

“…Together, these results suggest the utility of the in-house ELISA as a cost-effective tool for sero surveillance studies and monitoring the effect of interventions in resource-poor settings.…”
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Synthesis and biological assessment of chalcone and pyrazoline derivatives as novel inhibitor for ELF3-MED23 interaction by Soo-Yeon Hwang, Kyung-Hwa Jeon, Hwa-Jong Lee, Inhye Moon, Sehyun Jung, Seul-Ah Kim, Hyunji Jo, Seojeong Park, Misun Ahn, Soo-Yeon Kwak, Younghwa Na, Youngjoo Kwon

“…This intervention led to a substantial reduction in HER2 levels and its downstream signals in the HER2-positive gastric cancer cell line. …”
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A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis by Qifan Yang, Jing Liu, Yanwei Liu, Shun Liu, Xiaokang Wei, Yilin Yang, Weijie Zhang, Shuqi Zhang, Maosheng Zhang, Bin Liu, Xinyu Wang, Dong Zhu

“…Consequently, identifying suitable pharmacological interventions for obesity-induced osteoporosis, elucidating its underlying biological mechanisms, and developing nanodrug delivery systems with enhanced biocompatibility and targeted delivery remain significant challenges. …”
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EFFICACY OF ROXADUSTAT IN CHRONIC KIDNEY DISEASE PATIENTS NOT ON DIALYSIS WITH ANEMIA: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS by Lokman Hekim Tanriverdi, Ayşe Uysal, Arzu Akyay, Yurday Öncül, Ahmet Sarici

“…This study aimed to evaluate the efficacy of Roxadustat compared to control interventions in Non-Dialysis-Dependent CKD (NDD-CKD) patients. …”
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23ME-00610, a genetically informed, first-in-class antibody targeting CD200R1 to enhance antitumor T cell function by Jill Fenaux, Xin Fang, Yao-ming Huang, Cristina Melero, Caroline Bonnans, Earth Light Lowe, Tiziana Palumbo, Cecilia Lay, Zuoan Yi, Aileen Zhou, Mauro Poggio, Wei-Jen Chung, Sophia R. Majeed, Dylan Glatt, Alice Chen, Maike Schmidt, Clarissa C. Lee

“…Therefore, methods for identification of novel checkpoint targets and development of therapeutic interventions against them remain a critical challenge. …”
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Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases by Junfeng Chen, Kousuke Okimura, Liang Ren, Yusuke Nakane, Tomoya Nakayama, Yang Chen, Kai Fukawa, Soutarou Sugiyama, Takayoshi Natsume, Naoko Suda-Hashimoto, Mayumi Morimoto, Takako Miyabe-Nishiwaki, Takao Oishi, Yuma Katada, Manhui Zhang, Kohei Kobayashi, Shoko Matsumoto, Taiki Yamaguchi, Ying-Jey Guh, Issey Takahashi, Taeko Nishiwaki-Ohkawa, Daiki X. Sato, Yoshiharu Murata, Kenta Sumiyama, Atsushi J. Nagano, Hiroo Imai, Takashi Yoshimura

“…NHPSTA provides a molecular resource for seasonally regulated physiology and targets for therapeutic interventions for seasonally regulated diseases.…”
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Placental transfer of SARS-CoV-2 antibodies in mother-neonate pairs: a prospective nested cohort study by Alex G. Mugo, Angela Koech, Liberty Cantrell, Moses Mukhanya, Isaac Mwaniki, Joseph Mutunga, Merryn Voysey, Rachel Craik, Peter von Dadelszen, Kirsty Le Doare, Marleen Temmerman, Geoffrey Omuse, periCOVID-Africa, The PRECISE Network

“…Maternal sera were tested for SARS-CoV-2 receptor binding domain (RBD) IgM/IgG total antibodies using the Wantai assay. …”
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HIIT versus MICT in MASLD: mechanisms mediated by gut-liver axis crosstalk, mitochondrial dynamics remodeling, and adipokine signaling attenuation by Dongkun Deng, Lin Xu, Yufei Liu, Chang Li, Qingfeng Jiang, Jiaming Shi, Shuo Feng, Yunhua Lin

“…Furthermore, both interventions counteracted HFD-induced intestinal barrier dysfunction and restored gut-liver axis homeostasis. …”
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Swimming exercise induces redox-lipid crosstalk to ameliorate osteoarthritis progression by Yubin Wu, Mingzhuang Hou, Yaoge Deng, Xiaowei Xia, Yang Liu, Jianfeng Yu, Chenqi Yu, Huilin Yang, Yijian Zhang, Xuesong Zhu

“…Conventional pharmacotherapy exhibits limited efficacy in halting cartilage degeneration, whereas exercise interventions have demonstrated promising protective effects against osteoarthritis (OA), albeit with unclear underlying mechanisms. …”
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Terahertz wave targeting modulates the dedocking of neurotransmitters with receptors by Zhongjie Zhu, Yu Wu, Jie Wang, Te Ji, Wenming Qin, Zhi Zhu, Hongwei Zhao

“…Using molecular docking, we identified multiple binding sites for CA neurotransmitter molecules within the dopamine receptor D2 (DRD2). …”
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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT by SJ J. Diong, Aarti Jashnani, Andrew W. Drake, Christine Bee, Felix Findeisen, Gavin Dollinger, Feng Wang, Arvind Rajpal, Pavel Strop, Peter S. Lee

“…This work provides an improved foundational understanding of the PVR family network and mechanistic insight into therapeutic antibody intervention.…”
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Identifying a potential role of immune cells in gadolinium deposition within the brain by Dixy Parakkattel, Nico Ruprecht, Peter Broekmann, Sarah Guimbal, Chiara Stüdle, Sasha Soldati, Johannes T. Heverhagen, Britta Engelhardt, Hendrik von Tengg-Kobligk

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Boosting pancreatic cancer chemotherapy by disrupting nerve–cancer crosstalk by Yutian Xia, Jianzhong Zhang

“…A preclinical study has developed a precision nano-intervention strategy targeting tumor-associated nerves to destroy nerve-fueled tumor growth in pancreatic cancer. …”
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M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…Abstract Background Lung adenocarcinoma (LUAD), the predominant histological subtype of non-small cell lung cancer, demonstrates critical regulatory involvement of RNA-binding proteins (RBPs) and circular RNAs (circRNAs) in tumorigenic processes. …”
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Regulatory culture and architectural project by Mario Losasso

“…Hence, it oscillates between binding prescription and non-binding information levels or recommendations. …”
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Treatment optimization for iron deficiency anemia in pregnant women as a resource to prevent perinatal complications by T. P. Zefirova, R. R. Mukhametova, E. Iu. Iupatov, A. T. Khaertdinov

“…At the gestational age of 20–23 and 35–40 weeks, clinical data, routine hemogram parameters (hemoglobin level, hematocrit, erythrocyte concentration, erythrocyte indices, total iron binding capacity), serum ferritin-related iron balance, blood viscosity indices within high and low shear rates were investigated.   …”
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Identification of Marine Compounds Inhibiting NF-κBInducing Kinase Through Molecular Docking and Molecular Dynamics Simulations by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Jongseon Choe, Wanjoo Chun

“…By screening a library of bioactive marine compounds, we identified several promising candidates with strong binding affinity to the NIK active site. By continuously narrowing down the library at each step, we found that the compounds santacruzamate A, xanthosine, and actinonine stand out at each step by demonstrating compact binding, highly stable interactions, and the most favorable free energy profiles, indicating their potential as effective NIK inhibitors. …”
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Shared pathogenic mechanisms linking obesity and idiopathic pulmonary fibrosis revealed by bioinformatics and in vivo validation by Linjie Chen, Haojie Chen, Zinan Chen, Kunyi Zhang, Hongsen Zhang, Jiahe Xu, Tongsheng Chen

“…Molecular docking highlighted strong binding affinities (-6.3 to -9.6 kcal/mol) between dietary flavonoids and hub targets. …”
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Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts by Gloria Garoffolo, Thijs J. Sluiter, Anita Thomas, Luca Piacentini, Matthijs S. Ruiter, Alessia Schiavo, Massimo Salvi, Claudio Saccu, Stefano Zoli, Mattia Chiesa, Takumi Yokoyama, Marco Agrifoglio, Monica Soncini, Gianfranco B. Fiore, Fabio Martelli, Gianluigi Condorelli, Paolo Madeddu, Filippo Molinari, Umberto Morbiducci, Paul H. A. Quax, Gaia Spinetti, Margreet R. de Vries, Maurizio Pesce

“…Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. …”
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Impact of Di-(2-Ethylhexyl)-Phthalate on Metabolic Syndrome: Insights from Network Toxicology and Molecular Docking and Dynamics by Chen L, Huang YL, Liu F, Huang N, Zeng DC, Zhong YB, Liao JH, Wang MY

“…The KEGG pathway showed significant enrichment in AGE-RAGE, FoxO, insulin resistance, and steroid hormone biosynthesis pathways. DEHP showed strong binding affinity to core targets: TP53 (− 5.6 kcal/mol), ESR1 (− 6.1 kcal/mol), EGFR (− 5.4 kcal/mol), and IL6 (− 4.8 kcal/mol). …”
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