A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase by Annika Engel, Viktoria Wagner, Oliver Hahn, Aulden G. Foltz, Micaiah Atkins, Amila Beganovic, Ian H. Guldner, Nannan Lu, Aryaman Saksena, Ulrike Fischer, Nicole Ludwig, Eckart Meese, Tony Wyss-Coray, Andreas Keller

“…Herein, we present a spatio-temporal brain atlas (15 different regions) of microRNA expression across the mouse lifespan (7 time points) and two aging interventions. MicroRNAs are promising therapeutic targets, as they silence genes by complementary base-pair binding of messenger RNAs and mediate aging speed. …”
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Multi-gene duplication removal in an engineered human cellular MECP2 duplication syndrome model with an IRAK1-MECP2 duplication by Samar Z. Rizvi, Wing Suen Chan, Eleonora Maino, Sydney Steiman, Georgiana Forguson, Maya Klepfish, Ronald D. Cohn, Evgueni A. Ivakine

“…Furthermore, the outlined workflow is readily adaptable to model other CNV disorders and subsequently test genomic and pharmacological interventions.…”
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Optimizing carbohydrate quality: a path to better health for women with PCOS by Li Zhang, Yuxin Jin, Aili Yang, Xinwen Yu, Yi Li, Xin Wang, Chunni Heng, Biao Qi, Bin Gao, Guohong Zhao, Guohong Zhao, Guohong Zhao

“…Therefore, treatment strategies should incorporate personalized dietary interventions tailored to the specific needs of women with PCOS within a shared decision-making framework.Systematic review registrationwww.crd.york.ac.uk, identifier PROSPERO CRD42024579681.…”
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SARS-CoV-2 Variant-Specific Antibodies in Vaccinated Inflammatory Bowel Disease Patients by Eva Ulla Lorentzen, Richard Vollenberg, Rieke Neddermeyer, Michael Schoefbaenker, Eike R. Hrincius, Stephan Ludwig, Phil-Robin Tepasse, Joachim Ewald Kuehn

“…<b>Conclusion:</b> Variant-specific sVNTs and pVNTs have the potential to serve as valuable tools for evaluating the efficacy of adapted vaccines and to inform clinical interventions in the care of immunosuppressed patients. …”
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Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Additionally, binding energy calculations indicated that PubChem CID 122589735 exhibited the strongest binding affinity for katanin, with the binding free energy ranking as follows: 122589735 > 123629569 > ATP. …”
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Clinical and genetic features of CNGA3 achromatopsia in preschool children: novel insights into retinal architecture and therapeutic window for clinical trials by Yanting Lai, Yanting Lai, Aohan Hou, Aohan Hou, Linyan Zhang, Linyan Zhang, Limei Sun, Limei Sun, Miner Yuan, Miner Yuan, Xiaoyan Ding, Xiaoyan Ding

“…Patients with genetic variants potentially leading to structural changes in the cGMP binding site of the synthesized protein tend to exhibit more severe retinal phenotypes. …”
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Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging by Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan

“…PET imaging studies in mice reveal that [11C]CNY‐01 exhibits good brain uptake and binding specificity. Subsequent evaluation in non‐human primates further demonstrates that [11C]CNY‐01 displays favorable brain penetration, slow clearance kinetics, and characteristics of irreversible binding to its target in blockage experiments. …”
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Engineered mesenchymal stromal cells with interleukin-1beta sticky-trap attenuate osteoarthritis in knee joints by Christopher Kim, Christopher Kim, Biao Li, Biao Li, Sayaka Nakamura, Eric J. Neely, Jason S. Rockel, Tatiana Oussenko, Puzheng Zhang, Mohit Kapoor, Andras Nagy, Andras Nagy, Andras Nagy

“…Although stkIL1R2 was undetectable in the engineered MSC supernatants by enzyme-linked immunosorbent assay (ELISA) and Western blot, it was localized on the cell surface and extracellular matrix (ECM) and demonstrated specific binding to IL-1β using a fluorescent protein-fused binding assay. …”
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The regulatory mechanism of acidic tea polysaccharides from Wuyi rock tea on bile acids in type 2 diabetic rats by WU Zhong, YANG Jiangfan

“…At 2.00 mg/mL, the binding rate of the tea polysaccharides to sodium cholate were found to be 57.59% and 62.62% for sodium glycylcholate and sodium taurocholate, respectively. …”
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Identification of Potential Inhibitors of Histone Deacetylase 6 Through Virtual Screening and Molecular Dynamics Simulation Approach: Implications in Neurodegenerative Diseases by Anas Shamsi, Moyad Shahwan, Azna Zuberi, Nojood Altwaijry

“…The docking results indicate that penfluridol and pimozide share the same binding site as the reference inhibitor with HDAC6. …”
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Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy by Dan-Feng Cao, Xin-Yu Zhou, Qian Guo, Ming-Yao Xiang, Mei-Hua Bao, Bin-Sheng He, Xiao-Yuan Mao

“…Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. …”
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Light-induced epigenetic modifications in the hypothalamus during avian embryonic development enhance phenotypic plasticity by Joanna Bartman, Tali Rosenberg, Hadar Parnas, Ronit Yosofov, Natalie Avital-Cohen, Ron Weiss, Gal Harmatz, Israel Rozenboim, Asaf Marco

“…Targeted external interventions during this critical period can shape developmental trajectories and influence an animal’s phenotype. …”
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Molecular mechanisms of acquired idiopathic generalized anhidrosis: differential gene expression and potential therapeutic targets by Sanjukta Dasgupta

“…Molecular docking confirmed a strong binding affinity between ciprofibrate and JUN, suggesting ciprofibrate could modulate JUN activity and regulate AIGA symptoms. …”
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ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans by Weilin Kong, Guoli Gu, Tong Dai, Beibei Chen, Yanli Wang, Zheng Zeng, Mintie Pu

“…Differentially expressed genes between short-lived and long-lived isogenic worms regulate lifespan and are enriched for PQM-1 binding sites. pqm-1 in young to mid-aged adults causes individual ELO-6 expression heterogeneity and restricts health span and life span. …”
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Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors by Tom Pennance, Jacob A. Tennessen, Johannie M. Spaan, Tammie J. McQuistan, George Ogara, Fredrick Rawago, Kennedy Andiego, Boaz Mulonga, Meredith Odhiambo, Martin W. Mutuku, Gerald M. Mkoji, Eric S. Loker, Maurice R. Odiere, Michelle L. Steinauer

“…Interruption of transmission will require novel vector-focused interventions. We performed a genome-wide association study of African snails, Biomphalaria sudanica, exposed to Schistosoma mansoni in an endemic area of high transmission in Kenya. …”
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Association between Change in the peripheral biomarkers of inflammation, astrocyte activation, and neuroprotection at one week of critical illness and hospital mortality in patient... by Sikandar H Khan, Anthony J Perkins, Ahmed M Eltarras, Rosalyn Chi, Ammar A Athar, Sophia Wang, Noll L Campbell, Sujuan Gao, Malaz A Boustani, Babar A Khan

“…<h4>Patients</h4>178 ICU patients with delirium, alive and remaining in ICU at one week.<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Blood samples collected for a pair of previously published, negative, clinical trials were utilized. …”
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Analyzing mechanisms of qing fei bao yuan decoction granules in treating COPD based on LC-MS, network pharmacology and in vivo methods by Amei Tang, Yang Liu, Guoqiang Guan, Tong Hao, Feng Cao

“…Background and aim: The current therapeutic interventions of chronic obstructive pulmonary disease offer only partial alleviation of symptoms, leaving the majority of patients with persistent and significant clinical manifestations. …”
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Fasting as an Adjuvant Therapy for Cancer: Mechanism of Action and Clinical Practice by Yichun Xie, Huabin Ye, Zhongjun Liu, Zhiqing Liang, Jinrong Zhu, Rongxin Zhang, Yan Li

“…Additionally, elevated levels of insulin-like growth factor-binding proteins and ketone bodies may increase tumor cells’ dependence on their own metabolites, ultimately leading to their apoptosis. …”
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Identification of pharmacophore synergism for optimization of estrogen receptor beta binders for hormone dependent forms of breast cancer by Rania A. Hussien, Fatmah Ali S. Alasmary, Vijay H. Masand, Abdul Samad, Rahul D. Jawarkar, Gaurav S. Masand, Sami A. Al-Hussain, Magdi E.A. Zaki

“…Certain forms of breast cancer, particularly influenced by estrogen hormone, prompt the investigation of estrogen receptors as potential targets for therapeutic interventions. The drug discovery pipeline against breast cancer requires the identification and retention of crucial pharmacophoric features of inhibitors using a multitude of inhibitors comprising diverse scaffolds. …”
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Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling by Xiaoman Yang, Zhuoran Ma, Piaopiao Lian, Yi Wu, Ke Liu, Zhaoyuan Zhang, Zhicheng Tang, Yan Xu, Xuebing Cao

“…(D) The p38 inhibitor enhances kinesin transport by preventing p38 MAPK over-activation, reducing its inhibition of kinesin-cargo binding.…”
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