Integrated computational and in vivo approaches for promoter editing in SWEET genes to enhance sheath blight resistance in rice by Vignesh Ponnurangan, David Jesudoss, Varanavasiappan Shanmugam, R. K. Mohana Pradeep, Krish K. Kumar, Jayakanthan Mannu, Prakasam Vellaichamy, Paranidharan Vaikuntavasan

“…Overall, the present study provides a foundation for improving rice resistance to R. solani by targeting transcription factor-promoter interactions with advanced molecular interventions.…”
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Localized delivery and retention of hydrogen sulfide causing regional lipid accumulation in mouse adipose tissues in vivo by Richa Verma, Ming Fu, Hassan M. Arif, Guangdong Yang, Ishani Sarkar, Kuljeet Kaur, John B. Matson, Lingyun Wu, Rui Wang

“…The expressions of sterol regulatory element-binding protein, peroxisome proliferator-activated receptor-γ, adiponectin, and perilipin are all upregulated by H2S gel injections. …”
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Unveiling the impact of bisphenol a exposure on gene expression and immune response in diabetic nephropathy through integrative toxicogenomics and molecular dynamics approaches by Yan Zhang, Shan Lu, Yijun Dong, Jin Shang

“…The identified key genes and their interactions with BPA provide valuable insights into the pathophysiological mechanisms of BPA-induced DN, paving the way for future research and potential therapeutic interventions.…”
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<i>In Silico</i> Study of Alkaloid Compounds from <i>Sida rhombifolia</i> (Sidaguri) as Antimalarial Agents Targeting <i>Plasmodium falciparum</i> Dihydrofolate Reductase by Arfansyah Arfansyah, Anisa Sepyana, Bahrun Bahrun, Muh Ade Artasasta, Herlina Rasyid

“…The compounds exhibited binding energies of −7.22 and −8.41 kcal/mol, which are close to the native ligand (−7.31 kcal/mol). …”
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Tissue adaptation to metabolic stress: insights from SUMOylation by Hao Xie, Xin Liu, Shuo Li, Ming Wang, Ying Li, Ting Chen, Linwei Li, Faxi Wang, Xuan Xiao, Xuan Xiao

“…It achieves this by influencing protein-protein interactions, subcellular localization, protein stability, and DNA binding activity. Mounting evidence suggests that SUMOylation is implicated in the pathogenesis of metabolic disorders such as obesity, insulin resistance, and fatty liver. …”
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RETRACTED ARTICLE: Clinical and immuno-proteomic approach on Lantana camara pollen allergy—a major health hazard by Kavita Ghosal, Bodhisattwa Saha, Swati Gupta Bhattacharya

“…Total proteome was profiled in SDS–PAGE, 2D PAGE and immunoblotted to detect IgE binding proteins which were further identified using mass spectrometry. …”
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Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…Additionally, glycoproteins such as ZP3 within the zona pellucida are crucial for sperm binding and triggering the acrosome reaction. Recent gene-editing technologies, such as CRISPR/Cas9 and conditional knockout models, have facilitated the functional annotation of genes such as SPAM1 and ADAM family members, further elucidating their roles in capacitation and adhesion. …”
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Confronting the material and structural leakiness of plastics: insights from multi-sited ethnography in India, Indonesia and the Philippines by Anita Hardon, Tridibesh Dey, Diana Pakasi, Efenita May Taqueban, Irwan Hidayana, Mark Nichter

“…The authors call for a paradigm shift away from recycling and clean-up as core solutions, advocating instead for upstream interventions like production caps and chemical regulation. …”
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Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress. by Yuan Zhou, Li Tian, Lingzhi Long, Meifang Quan, Fei Liu, Jianguo Cao

“…Gene silencing of the CCAAT/enhancer binding protein homologous protein (CHOP) and pretreatment with salubrinal, an endoplasmic reticulum (ER) stress inhibitor, attenuated casticin-induced DR5 receptor expression, and apoptosis and ROS production. …”
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Nanoparticle integrated guar gum hydrogel-based immunosensor for biomedical application by Shweta Panwar, Suveen Kumar

“…Oral cancer biomarker detection is key for early diagnosis, personalized treatment, monitoring, enabling timely interventions and improved patient outcomes. We can easily investigate the stage of oral cancer through the detection of concentration of biomarkers secreted in saliva sample of oral cancer patients.…”
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Decoding m6A RNA methylation in kidney disorders: from molecular insights to therapeutic strategies by Qinfan Yao, Yitong Chen, Xinyi Zhang, Lefeng Wang, Jingyi Li, Junhao Lv, Jianghua Chen, Dajin Chen

“…By elucidating their roles in inflammation, fibrosis, apoptosis, and metabolic imbalance, this review highlights the translational potential of m6A-centric interventions and offers novel insights into epitranscriptomic regulation within renal pathophysiology.…”
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Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders by Hailin Wang, Ying Yang, Ziwei Ni, Xiaoting Qiao, Yaqian Guo, Xiaomin Wang, Duo Cao, Yayun Wang, Cailian Ruan

“…A comprehensive understanding of the pathogenesis of NDDs is crucial for the development of targeted therapeutic interventions. Zinc-finger transcription factors (ZFPs) play a pivotal role in regulating gene expression by modulating the binding of RNA polymerase to DNA, thereby either activating or repressing gene transcription. …”
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Cuproptosis and its potential role in musculoskeletal disease by Ziyang Xiang, Huiling Mei, Honglin Wang, Xiaoyue Yao, Ji Rao, Wentao Zhang, Aoshuang Xu, Lin Lu

“…This review synthesizes current insights into the molecular mechanisms of cuproptosis, its pathogenic role in musculoskeletal diseases, and the potential for biomarker-driven therapeutic interventions.…”
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Identification of GJC1 as a novel diagnostic marker for papillary thyroid carcinoma using weighted gene co-expression network analysis and machine learning algorithm by Jingshu Zhang, Ping Sun

“…Therefore, early recognition and specific interventions for PTC are crucial. The objective of this study is to explore novel diagnostic marker and precise intervention targets for PTC. …”
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Galectin-1 in Cardiovascular Pathogenesis: Unraveling Dual Roles and Mechanistic Insights in Emerging Research by Po-Yuan Chen, Chun-Yao Cheng, Chun-Chao Chen, Huan-Yuan Chen, Ju-Chi Liu, Wen-Rui Hao, Tzu-Hurng Cheng, Jin-Jer Chen

“…Galectin-1 (Gal-1), a β-galactoside-binding lectin, plays a complex role in cardiovascular diseases (CVDs), exerting both protective and pathological effects depending on the context. …”
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Decoding TDP-43: the molecular chameleon of neurodegenerative diseases by Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao

“…Abstract TAR DNA-binding protein 43 (TDP-43) has emerged as a critical player in neurodegenerative disorders, with its dysfunction implicated in a wide spectrum of diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD). …”
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Efficacy of Thymoquinone and Hesperidin in Attenuating Cardiotoxicity from 5-Fluorouracil: Insights from In Vivo and In Silico Studies by Juveriya Farooq, Rokeya Sultana, Jainey P. James, Zakiya Fathima C, Ali F. Almutairy, Abubakar Siddique Mustafa Hussain

“…5-Fluorouracil (5-FU) is widely used in chemotherapy but poses serious risks of cardiotoxicity, which can significantly affect treatment outcomes. Identifying interventions that can prevent these adverse effects without undermining anticancer efficacy is crucial. …”
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Competitive enzyme linked aptamer based assay for salivary melatonin detection by Meenakshi Pundir, Liubov Lobanova, Petros Papagerakis, Xiongbiao Chen, Silvana Papagerakis

“…Additionally, the aptamer showed small binding to its counter targets and acceptable recovery of melatonin when spiked in four times diluted saliva in assay buffer. …”
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Identification of age-related genes in rotator cuff tendon: a preliminary transcriptome study on tendon ageing by Yibin Liu, Xing Li, Lei Jiang, Jinjin Ma

“…Functional analyses and previous studies have highlighted their specific enrichments in biological functions, such as muscle development (e.g. myosin heavy chain 3 (MYH3)), transcription regulation (e.g. CCAAT enhancer binding brotein delta (CEBPD)), and metal ion homeostasis (e.g. metallothionein 1X (MT1X)). …”
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mRNA vaccine design using the proteome of Theileria annulata through immunoinformatics approaches by Roohollah Fattahi, Behrooz Sadeghi Kalani

“…The identified epitopes were localized within the antigen-binding sites of their respective MHC alleles. The newly formulated vaccine demonstrated stability, exhibited no toxicity, and showed non-allergenic characteristics. …”
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