Identification and evaluation of bioactive compounds from Azadirachta indica as potential inhibitors of DENV-2 capsid protein: An integrative study utilizing network pharmacology,... by Md. Ahad Ali Khan, Md. Nazmul Hasan Zilani, Mahedi Hasan, Nahid Hasan

“…Methods: The compound library was subjected to molecular docking to the capsid protein to identify potent inhibitors with high binding affinity. We selected 81 hits based on a thorough analysis of their binding affinities, particularly those exhibiting higher binding energy than the established inhibitor ST-148. …”
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Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses by Enza Maria Verde, Valentina Secco, Andrea Ghezzi, Jessica Mandrioli, Serena Carra

“…Understanding these regulatory pathways could offer new insights into targeted interventions aimed at mitigating cell toxicity and restoring cellular function.…”
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Traditional Chinese medicine-based therapeutics for Pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome by Yuexin Pan, Shalesh Gangwar, Mohamed Abbas, Khalid Raza

“…Abstract Pediatric pneumonia remains a leading cause of morbidity and mortality among children worldwide, necessitating the exploration of novel therapeutic interventions. Traditional Chinese Medicine (TCM) offers a rich repository of natural compounds with potential therapeutic benefits. …”
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Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface by Dan Song, Yang Li, Ling-Ling Yang, Ya-Xi Luo, Xiu-Qing Yao

“…These pathways are closely linked to core AD pathologies, including Aβ aggregation, tau hyperphosphorylation, neuroinflammation, oxidative stress and mitochondrial dysfunction. Lifestyle interventions, including exercise and dietary modifications, that regulate hepatokines expression may offer novel preventive and therapeutic strategies for AD. …”
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Unlocking the lipid code: SREBPs as key drivers in gastrointestinal tumour metabolism by Haowen Tang, Yuting Zhang, Danni Zhao, Minjie Guo, Xiao Yuan, Xu Wang

“…Through this review, we hope to provide new insights into precise interventions targeting various subtypes of the SREBP molecule.…”
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A brief review on metal-curcumin complexes: synthesis approaches and their pharmaceutical applications by Kuber Kumar Bhagat, Rameshwar S. Cheke, Vivekanand D. Gavali, Prashant S. Kharkar, Nitin D. Arote

“…Emphasizing the synthetic procedures of metal-curcumin complexes, this paper meticulously explores their characterization and illustrates their crucial involvement in medicinal applications and therapeutic interventions. Clinical trial number: Not applicable. …”
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Modeling diffusive search by non-adaptive sperm: Empirical and computational insights. by Benjamin M Brisard, Kylie D Cashwell, Stephanie M Stewart, Logan M Harrison, Aidan C Charles, Chelsea V Dennis, Ivie R Henslee, Ethan L Carrow, Heather A Belcher, Debajit Bhowmick, Paul W Vos, Maciej Majka, Martin Bier, David M Hart, Cameron A Schmidt

“…It is the latter that is of utmost concern for improving assisted reproductive technologies (ART) because low-fitness sperm may be inadvertently used for fertilization during interventions that rely heavily on artificial sperm selection, such as intracytoplasmic sperm injection (ICSI). …”
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Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects by Jose Crespo-Barrios

“…<b>Conclusions:</b> This hypothesis driven framework outlines a biologically plausible roadmap for longvax research. By matching interventions to specific mechanisms (fibrinolysis, spike neutralisation, pathogen clearance and regeneration), it aims to guide controlled trials and compassionate pilot programs directed at durable recovery rather than chronic symptom management.…”
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Pathophysiological and clinical significance of mineral homeostasis disorders in the development of cardiovascular disease by A. G. Kutikhin

“…Here, we critically discuss the pathophysiological consequences of CPP formation, mechanisms of their pathogenic effects, and potential therapeutic interventions.…”
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The new slave trade in Libya: evaluating the modern humanitarian crisis (2015–2024) by Festus Jusu Lahai

“…Using Marxist analysis and a Libya case study, this qualitative study draws on NGO and IGO reports (IOM, MSF, HRW) to reveal how neoliberal capitalism, imperialist interventions, and racial hierarchies sustain trafficking. …”
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A novel photocleavable amino-modified graphene for covalent purification of N-glycans from hepatocellular carcinoma patients’ serum for potential biomarkers discovery by Xuyuan Chao, Shengjie Yang, Baoying Zhang, Xin Zang, Jingyi Zhang, Xizi Liu, Lu Chen, Lu Qi, Xiaofeng Xue, Han Hu, Xinghe Wang

“…These methods exhibit relatively weak binding forces and low specificity based on non-covalent interactions. …”
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Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies by Xinyi Zhang, Xinyi Zhang, Zhongge Zhu, Peijie Zhai, Peijie Zhai, Peng Lv, You Yang, Chuanhang Cheng, Busen Wang, Ting Fang, Guanying Zhang, Xiangyang Chi, Jianmin Li, Wei Chen, Yunzhu Dong

“…Currently, no available vaccine or therapeutic interventions specifically targeting adenoviruses are available.MethodsIn this study, we isolated peripheral blood mononuclear cells (PBMCs) from HAdV-4 infected donors and generated fully human monoclonal antibodies using single-cell PCR technology. …”
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Design and screening of novel 1,2,4-Triazole-3-thione derivatives as DCN1 inhibitors for anticardiac fibrosis based on 3D-QSAR modeling and molecular dynamics by Wengong Bian, Yaxin Guo

“…The top compound exhibited a predicted pIC50 of 9.674 and showed strong binding affinity in molecular docking. Molecular dynamics simulations confirmed the stability of the compound at the binding site, while energy decomposition analysis identified key residues essential for binding interaction.ConclusionThis study successfully designed and evaluated novel DCN1 inhibitors using an integrated approach that combines 3D-QSAR modeling, molecular docking, and molecular dynamics simulations. …”
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Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy by Lu Chen, Sha Wang, Jinwei Wang, Bei Xu, Jia Tan, Xiaobo Xia

“…This study revealed hypoxia-immunity crosstalk in TAO pathogenesis, providing a validated predictive model and molecular targets for precision interventions.…”
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Valproate-vitamin E co-treatment preserved cortico-callosal white matter integrities in cypermethrin co-exposed pentylene tetrazole induced seizure by Aminu Imam, Oluwadamilola Eunice Ajibola, Aalimah Akinosho Akorede, Omamuyovwi Meashack Ijomone, Moyosore Salihu Ajao

“…This study investigates the effects of Cypermethrin (CPM) on Pentylenetetrazole (PTZ)-induced seizures and the Vitamin E (Vit E) and valproate (VAP) co-interventions on myelin and glial integrity. Methods Histochemical and immunohistochemical analyses for hematoxylin and eosin (H&E), myelin basic protein (MBP), ionized calcium-binding adaptor molecule 1 (IBA1), glial fibrillary acidic protein (GFAP), and oligodendrocyte transcription factor 2 (OLIG-2) were conducted on cerebral white matter and corpus callosum tissues. …”
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AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders by Daniel Choquet, Patricio Opazo, Hongyu Zhang

“…Notably, pharmacological interventions aimed at correcting deficits in AMPAR diffusional trapping have demonstrated efficacy in restoring synapse numbers, LTP, and memory functions in these diverse disease models, despite their distinct pathogenic mechanisms. …”
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High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19. by Sung Hee Ko, Elham Bayat Mokhtari, Prakriti Mudvari, Sydney Stein, Christopher D Stringham, Danielle Wagner, Sabrina Ramelli, Marcos J Ramos-Benitez, Jeffrey R Strich, Richard T Davey, Tongqing Zhou, John Misasi, Peter D Kwong, Daniel S Chertow, Nancy J Sullivan, Eli A Boritz

“…These mutations arose coincident with a 6.2-fold rise in serum binding to spike and a transient increase in virus burden. …”
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Brain Neurotrophins and Plant Polyphenols: A Powerful Connection by Marco Fiore, Sergio Terracina, Giampiero Ferraguti

“…Crucial pathways include mitigation of neuroinflammatory responses, activation of intracellular cascades such as the cAMP response element-binding protein (CREB), epigenetic modulation, and the diminution of oxidative stress. …”
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A plant Bcl-2-associated athanogene is proteolytically activated to confer fungal resistance by Mehdi Kabbage, Ryan Kessens, Martin B. Dickman

“…The remaining three members (BAG5-7) contain a predicted calmodulin-binding motif near the BAG domain, a feature unique to plant BAG proteins that possibly reflects divergent mechanisms associated with plant-specific functions. …”
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Correlation between iron accumulation and sarcopenia in middle-aged and elderly populations by Mahamane Rahoufou Tounaoua, Honggu Chen, Zakari Shaibu, Zhao Guo-yang

“…Data on age, sex, body mass index (BMI), limb muscle mass, white blood cell (WBC) count, C-reactive protein (CRP) level, serum iron concentration, ferritin level, total iron- binding capacity (TIBC), and transferrin saturation (TSAT) were collected and analyzed. …”
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