From surplus to sustainability: The role of legislation in reducing climate impact from Swedish bread waste by M. Eriksson, L. Bartek, F. Sturén, J. Christensen, C. Cicatiello, C. Giordano, C. Malefors, S. Pasanen, A. Sjölund, I. Strid, N. Sundin, P. Brancoli

“…While previous research has focused on interventions at the supplier-retailer interface to reduce surplus, this paper explores the reduction potential in applying legal instruments and evaluates the climate benefits of enforcing four different policy measures: 1) Prohibiting Unfair Trading Practices; 2) Advancing Redistribution of Surplus; 3) Enforcing Best Available Technology; and 4) Legally binding reduction targets. …”
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Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay by Yazun Jarrar, Mansour Almansour, Mansour Al-Sayed Ahmad, Belal O. Al-Najjar, Amin A. Al-Doaiss, Sireen Abdul Rahim Shilbayeh, Su-Jun Lee

“…Molecular docking simulations were performed using predicted structures of CYP4A11, CYP4F2, and CYP4F3B. The binding affinity of simvastatin was evaluated based on lowest energy of binding (LEB) values, and interactions with the heme group were analyzed. …”
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Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity by Andrea Kiss, Mohamad Mahfood, Zsófia Bodogán, Zoltán Kónya, Bálint Bécsi, Ferenc Erdődi

“…Biotin-TAT-MYPT1 competed for binding to PP1c with immobilized GST-MYPT1 in SPR assays and it partially relieved PP1c inhibition by thiophosphorylated (on Thr696 and Thr853) MYPT1. …”
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Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review by Yu H, Yu J, Yao G

“…This integration enables more targeted drug delivery, advanced imaging techniques, and improved therapeutic interventions, ultimately improving the management of cardiovascular diseases. …”
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Being able to think when caught in the maelstrom - how adolescents used mindfulness when facing exams by Ingrid Dundas, Per-Einar Binder

“…Purpose Research indicates that exam anxiety may decline with mindfulness-based interventions but there is a lack of research on adolescents’ accounts of the processes involved. …”
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L’inversion des rôles ? Aménageurs, promoteurs immobiliers et pouvoirs publics dans la régulation des ZAC du Grand Lyon by Romain Maurice

“…What can be defined as public or private sector interventions is becoming complicated. In this article, we study the stakeholder’s games happening in a particular French land development procedure, the “Zone d’aménagement concerté” (ZAC). …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…Unbiased transcriptional profiling analysis and cellular thermal shift assay suggested that Moscatilin suppresses vascular calcification via binding to interleukin 13 receptor subunit A2 (IL13RA2) and augmenting its expression. …”
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Inhibitory potential of polyphenolic stilbene derivatives with Glycogen Synthase Kinase-3β (GSK-3β) for Alzheimer's disease: Computational and SAR insights by Santosh Prasad Chaudhary Kurmi, Dipanjan Karati

“…The molecular docking binding affinity of Piceid (C12) compound was found -8.8 Kcal/mol which is higher than GSK-3β inhibitor standard compound Laduviglusib (C18) has binding energy -8.7 Kcal/mol. …”
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Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…Molecular dynamics simulations elucidated a dual inhibitory mechanism wherein these compounds competitively occupy the product (AMP)-binding site while simultaneously constraining conformational plasticity of the substrate-binding domain. …”
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Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach by Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li

“…Molecular docking simulations were conducted to assess the binding affinities between PFAS compounds and selected target proteins. …”
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Exploring the Cardioprotective Mechanisms of Ligusticum wallichii in Myocardial Infarction Through Network Pharmacology and Experimental Validation by Yang H, Cao J, Zhou L, Chen J, Tang J, Chen J, Yin L, Xie L, Li J, Luo J

“…Molecular docking was employed to validate the binding affinities between the core targets and the bioactive components. …”
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Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South... by Angelique Hölzemer, Christina F Thobakgale, Camilo A Jimenez Cruz, Wilfredo F Garcia-Beltran, Jonathan M Carlson, Nienke H van Teijlingen, Jaclyn K Mann, Manjeetha Jaggernath, Seung-gu Kang, Christian Körner, Amy W Chung, Jamie L Schafer, David T Evans, Galit Alter, Bruce D Walker, Philip J Goulder, Mary Carrington, Pia Hartmann, Thomas Pertel, Ruhong Zhou, Thumbi Ndung'u, Marcus Altfeld

“…<h4>Conclusions</h4>These data provide novel insights into how viruses can evade NK cell immunity through the selection of mutations in HLA-presented epitopes that enhance binding to inhibitory NK cell receptors. Better understanding of the mechanisms by which HIV-1 evades NK-cell-mediated immune pressure and the functional validation of a structural modeling approach will facilitate the development of novel targeted immune interventions to harness the antiviral activities of NK cells.…”
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Perceived Instructor’s Emotional Support and its Mediating Effect to Students’ Academic Resilience and Study Engagement: In the Case of a Higher Education Institution in the Philip... by Joseph Lobo

“…This investigation delved deep into the invisible threads binding student resilience and educational support. …”
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The structural basis of the G protein–coupled receptor and ion channel axis by Yulin Luo, Liping Sun, Yao Peng

“…Through unraveling the intricacies of the GPCR-ion channel axis, we aim to shed light on the sophisticated intermolecular dynamics within these pivotal membrane protein families, ultimately guiding the development of precise therapeutic interventions.…”
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Identification of novel therapeutic targets in hepatitis-B virus-associated membranous nephropathy using scRNA-seq and machine learning by Yongzheng Hu, Qian An, Xinxin Yu, Wei Jiang

“…Integrating scRNA-seq with machine learning offers valuable insights into the molecular landscape of HBV-MN, paving the way for novel interventions.…”
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Redefining Bioavailability to Accurately Predict Intracellular Therapeutic Targeting by Ahmed S. Ali, Abdulhadi S. Burzangi, Hanin S Aljuhani, Assmaa A Shaker

“…We propose that, in addition to absorption, other key factors such as protein binding, cellular penetration, metabolic stability, and the activity of efflux pumps should be incorporated into the bioavailability framework. …”
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Pseudothrombocytopenia and other conditions associated with spuriously low platelet counts by Marco Cattaneo

“…Conditions causing spurious thrombocytopenia include the following. 1) Pre-analytical errors, such as difficult venipunctures, over-/under-filling of blood collection tubes, insufficient mixing of blood with the anticoagulant (EDTA), which may cause fibrin formation; 2) EDTA-induced, temperature- and time-dependent, antibody-mediated in vitro platelet agglutination, with consequent reduction in the number of single platelets in the sample; the condition, referred to as Pseudothrombocytopenia, is benign and does not need follow-up or medical interventions; the use of alternative in vitro anticoagulants does not prevent agglutinates formation in all samples; accurate platelet counts could be obtained by testing EDTAsamples immediately after blood collection. 3) EDTA-induced in vitro platelet adherence to leukocytes (Platelet Satellitism), caused by bridging IgG antibodies binding to GPIIb-IIIa on platelets and the Fc receptor-III on leukocytes; occasionally, leukocytes may phagocytose platelets and/or form platelets/leukocytes clumps. 4) Presence of large/giant platelets (commonly from patients with congenital or acquired thrombocytopenia) that are not recognized as such by electronic counters, which distinguish platelets from other cells based on their smaller size. 5) Blood from patients with type 2B von Willebrand Disease, which may display large/giant platelets and platelet agglutinates. …”
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Omega-3 Fatty Acids and Exercise in Obesity Management: Independent and Synergistic Benefits in Metabolism and Knowledge Gaps by Viviana Sandoval, Álvaro Vergara-Nieto, Amanda Bentes, Saulo Silva, Carolina Núñez, Sergio Martínez-Huenchullán

“…Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), have been shown to lower triglyceride levels, enhance lipid metabolism, and modulate inflammation via pathways involving peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding protein-1c (SREBP-1c). Exercise interventions, such as moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), provide distinct yet complementary metabolic benefits. …”
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Anti-DAMP therapies for acute inflammation by Russell Hollis, Russell Hollis, Russell Hollis, Megan Tenet, Megan Tenet, Monowar Aziz, Monowar Aziz, Monowar Aziz, Ping Wang, Ping Wang, Ping Wang

“…Cellular injury, central to shock pathophysiology, triggers the release of damage-associated molecular patterns (DAMPs), such as extracellular cold-inducible RNA-binding protein (eCIRP), high-mobility group box 1 (HMGB1), histones 3 and 4, and adenosine triphosphate (ATP). …”
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Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation by Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi

“…Akt1 presents a promising target for therapeutic intervention. Aims This study aimed to evaluate the binding affinities of 61 flavonoid‐derived natural compounds to the Akt1 ATP‐binding site using molecular docking with AutoDock to identify potential Akt1 inhibitors. …”
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