Xist condensates: perspectives for therapeutic intervention by Irene Perotti, Laura Broglia, Gian Gaetano Tartaglia, Andrea Cerase

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Human Amniotic Epithelial Stem Cell Exosomes Regulate Chondrocyte Ferroptosis through ACTA2-AS1-Targeted Binding to ACSL4 for Osteoarthritis Intervention by Xiaofei Wang, Zhimin Wu, Lei Xu, Linbing Lou, Yuxia Yang, Jian Zhang, Haixiang Miao, Cunyi Xia, Zhiwei Peng, Dongsheng Yang, Zhiwen Tao, Xiangji Meng, Wenkang Liu, Meijuan Yuan, Jingcheng Wang, Wenyong Fei, Jihang Dai

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Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis by Manshu Yu, Junyi Zhao, Yun Shan, Huibo Dai, Lei Tang, Li Sheng, Lu Zhang, Meixiao Sheng

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Computational identification of uncharacterized cruzain binding sites. by Jacob D Durrant, Henrik Keränen, Benjamin A Wilson, J Andrew McCammon

“…In the current work, molecular dynamics simulations and a sequence alignment of a non-redundant, unbiased set of peptidase C1 family members are used to identify uncharacterized cruzain binding sites. The two sites identified may serve as targets for future pharmacological intervention.…”
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Endotoxin Binding by Sevelamer: Potential Impact on Nutritional Status by Natsuki Kubotera, Alexander J. Prokopienko, Adinoyi O. Garba, Amy Barton Pai

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Multifaceted roles of Galectins: from carbohydrate binding to targeted cancer therapy by Nan Zhang, Qiao Liu, Daihan Wang, Xiaoyun Wang, Zhaoping Pan, Bo Han, Gu He

“…This review offers a comprehensive overview of the structural characteristics, ligand-binding properties, and interacting proteins of Galectins. …”
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The role of RNA binding proteins in cancer biology: A focus on FMRP by Yunlu Jia, Ruyin Jia, Yongxia Chen, Xuanyi Lin, Nadire Aishan, Han li, Linbo Wang, Xiaochen Zhang, Jian Ruan

“…RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells, exerting precise control over processes such as RNA splicing, transport, localization, stability, and translation through their specific binding to RNA molecules. …”
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Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051 by Yuxiang Luo, Zhaoyue Yan, Xiakun Chu, Ying Zhang, Yufan Qiu, Huilin Li

“…Our results revealed that PCI-34051 engages with an expanded set of residues and conforms more aptly to the binding channel of hHDAC8, stabilizing the flexible loops surrounding the binding channel. …”
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Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection by Supawich Boonkua, Orawan Thongsum, Rueangtip Chantunmapitak, Purimpuch Soongnart, Somkid Jaranathummakul, Kitima Srisanga, Patompon Wongtrakoongate, Somluk Asuvapongpatana, Wattana Weerachatyanukul, Atthaboon Watthammawut, Monsicha Somrit

“…The interaction between the SARS-CoV-2 spike protein and the host ACE2 receptor is influenced by carbohydrate-mediated mechanisms, as the spike is heavily glycosylated with terminal sialic acids, making these sugar moieties attractive targets for therapeutic intervention. We aimed to study the complete replacement of their protrusion domains of Macrobrachium rosenbergii nodavirus capsid protein with the larger ligands in the form of carbohydrate-recognition domain derived from a terminal sialic acid-binding lectin (tsCRD). …”
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Impact of non‐binding FDA guidances on primary endpoint selection in Alzheimer's disease trials by Jeffrey C. Yu, Jakub P. Hlávka, Elizabeth Joe, Frances J. Richmond, Darius N. Lakdawalla

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Exploring RNA binding proteins in hepatocellular carcinoma: insights into mechanisms and therapeutic potential by Xing Ren, Wenna Yang, Xiuli Yan, Hui Zhang

“…Elucidating the intricate molecular pathways that drive the progression of HCC is imperative for devising targeted and effective therapeutic interventions. RNA-binding proteins (RBPs) serve as pivotal regulators of post-transcriptional processes, influencing various cellular functions. …”
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RNA-binding proteins and autophagy in lung cancer: mechanistic insights and therapeutic perspectives by Xiao Lei, Yuexin Zheng, Wenmei SU

“…Its progression is intricately associated with the dynamic regulation of autophagy and RNA-binding proteins (RBPs), which play crucial roles in mRNA stability, alternative splicing, and cellular stress responses. …”
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Exploring Visuo-Tactile Temporal Binding Window Plasticity in Obsessive-Compulsive Disorder by Francesca Rastelli, Davide Fausto Borrelli, Francesca Ferroni, Anna Di Donna, Laura Dell’Uva, Maurizio Cavazza, Matteo Tonna, Martina Ardizzi

“…Among these, the temporal binding window (TBW) specifically refers to the temporal range within which stimuli are perceived as simultaneous and integrated. …”
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RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights by Jens Rummens, Sandrine Da Cruz

“…A large body of evidence highlights the critical role of RNA-binding proteins (RBPs) – in particular TAR DNA-binding protein 43 (TDP-43) and Fused in sarcoma (FUS) – in the pathogenesis of these diseases. …”
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In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets by Rengaraj GOMATHI, Hariharan USHA, Thoudam BHAIGYABATI, Sanasam SUCHITRA, Pandian PARTHIBAN

“…These findings emphasize the pharmacological significance of M. sativa and its potential for advancing cardiovascular health interventions. …”
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Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration by Hao Lv, Mei Lv, Xuyang Guo, Xiaoman Zhu, Yue Chao, Dandan Li

“…Lipopolysaccharide-binding protein (LBP), implicated in cancers such as lung, colon, and cervical cancer, has emerged as a promising candidate. …”
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The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis by Lu Zhao, Xin Chen, Yanan Zhang, Yixuan Cen, Tingjia Zhu, Lingfang Wang, Lili Xia, Yang Li, Xiaodong Cheng, Xing Xie, Weiguo Lu, Junfen Xu

“…Abstract Background Cervical cancer progresses through distinct precancerous stages, making early screening and intervention crucial for prevention. However, conventional screening modalities, such as cytology and HPV testing, face challenges related to sensitivity, specificity, and resource dependency. …”
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Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

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Retinol-binding protein 4 in skeletal and cardiac muscle: molecular mechanisms, clinical implications, and future perspectives by Kangzhen Zhang, Lijuan Wang, Wei Gao, Rong Guo

“…Retinol-binding protein 4 (RBP4) has emerged as a critical adipokine involved in the pathophysiology of metabolic and cardiovascular diseases. …”
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Deciphering the regulatory programs of RNA binding proteins in rheumatoid arthritis through single-cell transcriptome analysis by Hongbin Luo, Qunya Zheng, Youzheng Zhou, Weipeng Lai, Nanwen Zhang, Peng Chen

“…Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of RNA-binding proteins (RBPs), which are critical for alternative mRNA splicing and translational control in rheumatoid arthritis (RA). …”
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