Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology by Alexander M. Bernhardt, Sigrun Roeber, Viktoria Ruf, Elisabeth Wlasich, Endy Weidinger, Sebastian Longen, Svenja V. Trossbach, Johannes Gnörich, Matthias Brendel, Jochen Herms, Armin Giese, Günter U. Höglinger, Johannes Levin

“…Abstract We present the case of a 74-year-old woman with behavioral variant frontotemporal dementia (bvFTD) linked to a pathogenic TANK-binding kinase 1 (TBK1) mutation (c.1349_1352del; p.Ile450Lysfs*15). …”
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Reconstitution of Methionine Cycle With ATP Regeneration for Whole‐Cell Catalysis of Creatine Production in Engineered Escherichia coli by Yuhua Sheng, Yaokang Wu, Linpei Zhang, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu

“…Then, the expression level of GAMT, the critical rate‐limiting enzyme, was optimised by screening the ribosome binding site and N‐terminal coding sequences, resulting in a 92% enhancement of CR production, reaching 1.59 g/L. …”
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Exploring the functional variations of key candidate genes affecting egg production by hypothalamic-pituitary-ovarian axis in chickens by Dandan Wang, Yiqian Zhu, Jiajia Dong, Yihao Zhi, Guanghui Wei, Xiangtao Kang, Xiaojun Liu

“…Functional analysis indicated that the T allele of chr3:79510218A>T enhanced the transcriptional activity and upregulated PHIP expression in vitro by binding transcription factor forkhead box I1 (FOXI1). …”
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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Mechanistically, TSG-6 promoted tuft cells differentiation and increased interleukin-25 (IL-25) levels by directly binding to Pou class 2 homeobox 3(Pou2f3) and up-regulating its expression in the gut. …”
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EV‐Elute: A universal platform for the enrichment of functional surface marker‐defined extracellular vesicle subpopulations by Willemijn S. deVoogt, Rowan Frunt, Raul M. Leandro, Casper S. Triesscheijn, Bella Monica, Ioanna Paspali, Mark Tielemans, Jerney J. J. M. François, Cor W. Seinen, Olivier G. deJong, Sander A. A. Kooijmans

“…EV subpopulations showed intact integrity by electron microscopy and Proteinase K protection assays and showed uptake patterns similar to whole EV isolates in co‐cultures of peripheral blood mononuclear cells (PBMCs) and endothelial cells. …”
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Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage by Yang Yue, Qingyu Li, Changguo Chen, Juntao Yang, Weian Song, Changdong Zhou, Yuke Cui, Zhenqiao Wei, Qi He, Chenhui Wang, Hongjun Lin, Jiangbo Li, Jian Li, Ji Xi, Xiang Song, Wen Yang, Ze Zhang, Wenjie Shu, Liang Guo, Shengqi Wang

“…Mechanistically, PB1-F2 of IAV was revealed as a novel viral transcriptional factor to bind to the TATA box of PNP promoter, leading to enhanced purine salvage in H1N1-challenged AECs. …”
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Computational analysis of Ayurvedic metabolites for potential treatment of drug-resistant Candida auris by Mohibullah Shah, Mahnoor Zia, Iqra Ahmad, Muhammad Umer Khan, Hasan Ejaz, Maqsood Alam, Shahid Aziz, Umar Nishan, Hanna Dib, Riaz Ullah, Suvash Chandra Ojha

“…The results showed stable interactions for trans-p-coumaric acid and MCPHB, suggesting that all the ligands maintain stable binding interactions with the protein, which preserves structural integrity across all systems. …”
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Exploring the Mechanisms of the Antioxidants BHA, BHT, and TBHQ in Hepatotoxicity, Nephrotoxicity, and Neurotoxicity from the Perspective of Network Toxicology by Jing Ren, Ziang Li, Xiaofen Li, Lin Yang, Zhulin Bu, Yuhui Wu, Yuting Li, Shuosheng Zhang, Xianglong Meng

“…Core-acting genes were further screened through protein–protein interactions (PPIs), and molecular docking was performed to verify the binding free energy between BHA, BHT, and TBHQ and their core targets. …”
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The Role of TDP-43 in SARS-CoV-2-Related Neurodegenerative Changes by Dong-Hwi Kim, Jae-Hyeong Kim, Min-Tae Jeon, Kyu-Sung Kim, Do-Geun Kim, In-Soo Choi

“…Several studies have found that pathological changes in transactive response DNA-binding protein of 43 kDa (TDP-43) are involved in these cases. …”
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Exploring the mechanism of platycodin D in inhibiting nasopharyngeal carcinoma based on network pharmacology combined with experimental validation by LEI Benlan, YANG Jiangping, CHEN Yanfang, HUANG Jinglun, ZHANG Xiping, MA Canfang, LIANG Gang, JIAO Aijun

“…The molecular docking results showed that platycodon D had good binding activity with the core target. Cellular experiments revealed that platycodin D significantly inhibited NPC cell proliferation, migration, and colony formation, while inducing apoptosis and down-regulating the expression of p-ERK protein (P < 0.05). …”
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The developmental transcriptome dynamics of current-year shoot utilized as scion in Camellia chekiangoleosa by Yu Sheng, Haili Gao, Chunlian Yu, Guangyuan Huang, Kunxi Wang, Kailiang Wang, Leyan Lv, Wei Long

“…Conclusions Integrating transcriptomics and physiology defined the dynamic signature of changes in composition of cell wall and gene activity during the development of current-year shoots in C. chekiangoleosa. …”
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Enhanced Immune Response Against Echinococcus Granulosus Through a CTLA-4/B7 Affinity-Based Vaccine by Yuejie Zhu, Yueyue He, Ziyue Yin, Na Chen, Xingxing Qi, Jianbing Ding, Yujiao Li, Fengbo Zhang

“…Molecular docking (MD) and molecular dynamics simulations (MDS) revealed a strong binding affinity between <i>CVE31-162</i> and B7 molecules. …”
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Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3 by Le Zhang, Yan Xie, Shun Wang, Moxuan Gong, Zheping Chen, Chuanxin Wang, Peilong Li

“…In addition, a dual-luciferase reporter assay showed that KLF15 could activate Jmjd1c transcription by binding to the SE of Jmjd1c. Functionally, enhanced Jmjd1c can inhibit the levels of inflammatory cytokines such as IL-6, TNF-α, IL-1β, and inhibited the progression of NP, whereas silencing Jmjd1c had the opposite effect. …”
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Short-chain polyphosphates induce tau fibrillation and neurotoxicity in human iPSC-derived retinal neurons by Lorenzo Barolo, Lorenza Mautone, Ylenia Gigante, Silvia Ghirga, Francesco Mura, Maria Vittoria Farina, Stefano Tacconi, Luciana Dini, Giancarlo Ruocco, Alberto Boffi, Edoardo Milanetti, Silvia Di Angelantonio, Paola Baiocco

“…To explore the translational implications of NaTPP-induced fibrils, we assessed their long-term effects on cellular viability, tubulin integrity, and stress responses in retinal neuron cultures. …”
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Network Pharmacology and Experimental Validation Reveal Sishen Pill&rsquo;s Efficacy in Treating NSAID-Induced Small Intestinal Ulcers by Zhou J, Zhu F, Liang H, Sun L

“…Molecular docking revealed high binding affinity of SSP components (quercetin, bavachinin, rutaecarpine, evodiamine) to key targets (AKT1, HSP90AA1, IL6, MAPK1, BCL2). …”
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Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restriction by Chen Cheng, Trent Su, Marco Morselli, Siavash K. Kurdistani

“…Conclusions Our findings reveal a chromatin-based mechanism by which cells integrate metabolic status with transcriptional regulation to adapt to amino acid limitation. …”
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A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…The cytoplasmic membrane binding protein BIN1 is involved in subcellular trafficking and endocytosis. …”
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Lumefantrine ameliorates DSS-induced colitis by targeting FLI-1 to suppress NF-κB signaling by Ji Yang, Peng Guo, Peng Guo, Hongtao Luo, Xin Tang, Wei Liu, Xiaolin Ren, Xiaolin Ren, Xiaolin Ren

“…Additionally, NF-κB signaling modulation was assessed in lipopolysaccharide (LPS)-stimulated intestinal epithelial cells (IEC-6 and NCM460) via Western blot analysis.ResultsOral administration of Lumefantrine significantly attenuated disease activity index (DAI) scores and restored intestinal barrier integrity through upregulation of epithelial tight junction proteins Claudin-1 and ZO-1. …”
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Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia by Adnan Akif, Thi Thanh My Nguyen, Langni Liu, Xiaotian Xu, Amol Kulkarni, Jianxiong Jiang, Yang Zhang, Jiukuan Hao

“…Abstract Background As a key inflammatory factor, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in neuroinflammation and the progression of neurodegenerative diseases. …”
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Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery by Christopher Simon, Occam Kelly Graves, Oluwaseun Akeju, Tina B. McKay

“…Clarification as to how postoperative delirium might lead to neurodegenerative dementias, perhaps through evidence of contemporaneous biomarkers, would heighten the plausibility of a causal correlation. TAR DNA-binding protein 43 (TDP-43), a nuclear protein essential for transcriptional events, has been linked to pathological aggregation in Alzheimer's disease (AD) and AD-related dementias (ADRD). …”
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