Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan by Yaqi Liu, Chelsea M. Brown, Satchal Erramilli, Yi-Chia Su, Shih-Yun Guu, Po-Sen Tseng, Yu-Jen Wang, Nam Ha Duong, Piotr Tokarz, Brian Kloss, Cheng-Ruei Han, Hung-Yu Chen, José Rodrigues, Kay-Hooi Khoo, Margarida Archer, Anthony A. Kossiakoff, Todd L. Lowary, Phillip J. Stansfeld, Rie Nygaard, Filippo Mancia

“…AftB has a distinctive irregular, tube-shaped cavity that connects two proposed substrate binding sites. Through an integrated approach combining structural analysis, biochemical assays, and molecular dynamics simulations, we delineate the molecular basis of AftB’s reaction mechanism and propose a model for its catalytic function.…”
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Biomarker panels for improved risk prediction and enhanced biological insights in patients with atrial fibrillation by Pascal B. Meyre, Stefanie Aeschbacher, Steffen Blum, Tobias Reichlin, Moa Haller, Nicolas Rodondi, Andreas S. Müller, Alain Bernheim, Jürg Hans Beer, Giorgio Moschovitis, André Ziegler, Bianca Wahrenberger, Elia Rigamonti, Giulio Conte, Philipp Krisai, Leo H. Bonati, Stefan Osswald, Michael Kühne, David Conen

“…Additionally, GDF-15, insulin-like growth factor-binding protein-7 (IGFBP-7), NT-proBNP, and hsTropT predict heart failure hospitalization, while GDF-15 and IL-6 are associated with major bleeding events. …”
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Genome-wide exploration of beneficial Bacillus subtilis isolate from resistant banana cultivar Anaikomban towards the management of Fusarium wilt in banana by B.R. Ajesh, P. Renukadevi, N. Saranya, N. Vidhyashri, S. Varanavasiappan, S. Vellaikumar, Suhail Ashraf, S. Haripriya, Mohammad Raish, S. Nakkeeran

“…Molecular docking identified surfactin as the most potent AMP, exhibiting the highest binding affinity (−12.1 kcal/mol) to key Foc target proteins. …”
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Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication. by Masha Sorin, Jennifer Cano, Supratik Das, Sheeba Mathew, Xuhong Wu, Kelvin P Davies, Xuanling Shi, S-W Grace Cheng, David Ott, Ganjam V Kalpana

“…We found that SAP18 (Sin3a associated protein 18 kD), a component of the Sin3a-HDAC1 complex, directly binds to INI1 in yeast, in vitro and in vivo. Interestingly, we found that IN also binds to SAP18 in vitro and in vivo. …”
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Chlorogenic Acid: A Promising Strategy for Milk Preservation by Inhibiting <i>Staphylococcus aureus</i> Growth and Biofilm Formation by Xiaoyan Yu, Yufang Li, Xue Yang, Jinze He, Wenhuan Tang, Yunmei Chai, Zuyan Duan, Wenjie Li, Dan Zhao, Xuefeng Wang, Aixiang Huang, Hong Li, Yanan Shi

“…It forms hydrogen bonds with penicillin-binding protein 4 (PBP4), Amidase, glutamate synthetase B, and glutamate synthetase A. …”
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<i>SHROOM3</i> Deficiency Aggravates Adriamycin-Induced Nephropathy Accompanied by Focal Adhesion Disassembly and Stress Fiber Disorganization by Li-Nan Xu, Ying-Ying Sun, Yan-Feng Tan, Xin-Yue Zhou, Tian-Chao Xiang, Ye Fang, Fei Li, Qian Shen, Hong Xu, Jia Rao

“…<i>SHROOM3</i> encodes an actin-binding protein involved in kidney development and has been associated with chronic kidney disease through genome-wide association studies. …”
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AMP-IBP5: A Multifunctional Antimicrobial Peptide for Advanced Wound Healing and Inflammatory Skin Disorders by Alafate Abudouwanli, Ge Peng, Mengyao Yang, Wanchen Zhao, Quan Sun, Shan Wang, Yi Tan, Arisa Ikeda, Hideoki Ogawa, Ko Okumura, François Niyonsaba

“…AMP-IBP5, a novel AMP derived from insulin-like growth factor-binding protein 5, exhibits both antimicrobial and wound-healing properties, making it a promising therapeutic candidate. …”
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Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex by Feng Zhang, Sun-Han Zhang, Teng Liu, Guang-Su Xie, Shi-Hua Deng, Ting Zhang, Xiao-Bian Wang, Yue-Yan Yang, Zi-Xin Chen, Dong-Ming Wu, Ying Xu

“…Cell viability was assessed using the cell counting-kit 8 assay, and cell membrane integrity was evaluated using the lactate dehydrogenase release assay. …”
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Impaired intestinal permeability in patients with multiple sclerosis by Lenka Fialova, Pavla Barilly, Ivana Stetkarova, Ales Bartos, Libuse Noskova, Denisa Zimova, Michal Zido, Iva Hoffmanova

“…The aim of this study was to evaluate the integrity of the intestinal barrier in patients with clinically definite multiple sclerosis (CDMS) and clinically isolated syndrome (CIS) using two serum biomarkers, claudin-3 (CLDN3), a component of tight epithelial junctions, and intestinal fatty acid binding protein (I-FABP), a cytosolic protein in enterocytes. …”
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Overlooked role of long capping time and environmental factors in the plateau lake for impairing lanthanum-modified-bentonite's immobilization to phosphate by Jinhui Wang, Lina Chi, Shuai Liu, Jiao Yin, Youlin Zhang, Jian Shen, Xinze Wang

“…Here, we investigated the effect of long-term capping and integrated environmental factors in the plateau lake including alkalinity, organic matter, disturbance and photodegradation to the LMB immobilization. …”
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Durability Assessment of Binary and Ternary Eco-Friendly Mortars with Low Cement Content by Lucas Henrique Pereira Silva, Jacqueline Roberta Tamashiro, Fabio Friol Guedes de Paiva, João Henrique da Silva Rego, Miguel Angel de la Rubia, Angela Kinoshita, Amparo Moragues Terrades

“…Chemically, the SCMs enhanced the chloride-binding capacity of the cementitious matrix by up to seven times in the case of the 20BCC mortar, thereby improving its durability. …”
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Biophysical Characterization of Shrimp Hemocyanins: Stability and Emerging Biotechnological Applications by Lierge Ramos, Claudemir O. Souza, Ísis Sebastião, Giovana Bertini, Francisco Adriano de Oliveira Carvalho, Regildo Márcio Gonçalves da Silva, Edson Miguel Vilanculo, Julianne Soares Pereira, Patrícia Soares Santiago

“…The protein maintained its oligomeric stability and oxygen-binding affinity in the pH range of 5.0–7.4. However, extreme pH conditions (below 4.4 and above 7.5) induced structural alterations, leading to dissociation and conformational changes, as evidenced by fluorescence emission and UV-Vis spectra. …”
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Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity by Songshan Li, Minghan Li, Yantong Cai, Jun Xian, Rongrong Zhu, Chan Yang, Xin Zhang, Shuya Ren, Aijiao Yu, Shuwen Liu, Bin Yang

“…Further, we discovered that UCM05 destroys the membrane integrity of viral particles by directly binding with HSV-2 glycoproteins gB and gD and reduces viral replication by inhibiting viral protein synthesis and fatty acid synthesis. …”
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Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs by Shuai Zhang, Xue Feng, Chong-Hui Li, Yuan-Ming Zheng, Meng-Ya Wang, Jun-Jie Li, Yun-Peng Dai, Naihe Jing, Jia-Wei Zhou, Gang Wang

“…Gene profiling combined with reporter assays demonstrated that Mediator Med23 controls Sp1-directed gene programs related to oligodendrocyte differentiation and cholesterol metabolism. Integrative analysis demonstrated that Med23 modulates the P300 binding to Sp1-targeted genes, thus orchestrating the H3K27 acetylation and enhancer activation for the oligodendrocyte lineage progression. …”
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<i>Euphorbia humifusa</i> Willd. ex Schltdl. Mitigates Liver Injury via KEAP1-NFE2L2-Mediated Ferroptosis Regulation: Network Pharmacology and Experimental Validation by Hongxu Du, Kunzhao Yang, Jingyi Yang, Junjie Wan, Yu Pan, Weijie Song, Shuang Xu, Cheng Chen, Jiahui Li

“…Molecular docking revealed robust binding affinities between these compounds and ferroptosis-related proteins. …”
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Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells by Si-Fan Guo, Zhi-Bo Wang, Dan-Dan Xie, Ying Cai, Yan Wang, Xian Wang, Qiang Yang, Ai-Hua Zhang, Shi Qiu

“…Traditional Chinese Medicine offers complementary and integrative approaches in the management of rheumatoid arthritis, potentially providing additional options that may help address treatment challenges and enhance overall patient care. …”
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Assessing Heavy Metal Contamination in Food: Implications for Human Health and Environmental Safety by Magdalena Mititelu, Sorinel Marius Neacșu, Ștefan Sebastian Busnatu, Alexandru Scafa-Udriște, Octavian Andronic, Andreea-Elena Lăcraru, Corina-Bianca Ioniță-Mîndrican, Dumitru Lupuliasa, Carolina Negrei, Gabriel Olteanu

“…Finally, this study advocates for integrated, multidisciplinary strategies aimed at mitigating these risks, enhancing ecosystem stability, and ensuring long-term food security in the face of environmental challenges.…”
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Enhancing Medium-Chain Fatty Acid Delivery Through Bigel Technology by Manuela Machado, Eduardo M. Costa, Sara Silva, Sérgio C. Sousa, Ana Maria Gomes, Manuela Pintado

“…The bigels exhibited high oil binding capacity, ranging from 87% to 98%, effectively retaining MCFAs within the matrix, with lauric acid (C12) being the main component detected within the bigels at 178.32 ± 0.10 mg/g. …”
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Therapeutic potential of Litsea cubeba essential oil in modulating inflammation and the gut microbiome by Liqiong Xia, Ran Li, Ran Li, Ting Tao, Ruimin Zhong, Haifang Du, Ziling Liao, Zhanghua Sun, Changqiong Xu, Changqiong Xu

“…Citral, a major component of LCEO, showed robust binding to IL-1β, IL-6, and TNF-α, exerting anti-inflammatory effects through hydrogen bonding interactions. …”
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Targeting Redox Signaling Through Exosomal MicroRNA: Insights into Tumor Microenvironment and Precision Oncology by Moon Nyeo Park, Myoungchan Kim, Soojin Lee, Sojin Kang, Chi-Hoon Ahn, Trina Ekawati Tallei, Woojin Kim, Bonglee Kim

“…Ultimately, this work aims to guide future research and drug discovery efforts toward integrating herbal medicine and redox biology in the fight against cancer.…”
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