Surface‐Anchored Ticagrelor Gelatin Nanoparticles‐Platelets System for Enhanced Anti‐PD‐L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines by Qi Lu, Hao Ye, Jian Zhao, Xiaoyuan Fan, Kaiyuan Wang, Zeyu Han, Tian Liu, Lili Du, Jiaxuan Song, Helin Wang, Haotian Zhang, Zhonggui He, Jin Sun

“…Additionally, this strategy weakens the activated platelets’ contribution to tumor vascular integrity, improving the extravasation and chemotherapeutic efficacy of nanomedicines. …”
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An In vitro Investigation of the Potential Synergistic Effect of 3-Hydrazinoquinoxaline-2-Thiol and Thymoquinone’s against Methicillin Resistant Staphylococcus aureus (MRSA) by Karem Ibrahem, Wafaa Alhazmi, Hanouf A. Niyazi, Hatoon A. Niyazi, Bandar Saleh, Tariq Ekhmimi, Jawahir A. Mokhtar, Dalya Attallah, Mohammed Bazuhair, Khalil Alkuwaity, Ahmad Sait, Mohammed Mufrrih, Mazen Ismail, Yousef Almoghrabi, Hussam Daghistani, Ohood Alharbi, Hisham Altayb, Abdelbagi Alfadil

“…Moreover, the checkerboard-assay was utilized to evaluate the integration of the following antimicrobial agents; thymoquinone and 3HT. …”
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Exonuclease-III assisted specific target recognition cooperating with primer exchange reaction for sensitive and label-free microRNA detection by Xiaoqin Fu, Xiaoyan Fu, Didi Wu, Yunyao Lu

“…Through Exo-III-mediated recycling, the released PER template binds to primer-conjugated magnetic beads (primer@MBs), initiating a polymerase-assisted PER amplification process. …”
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High expression of THY1 is a prognostic marker for gastric Cancer: Deciphering its transcriptional regulation as a component of the Epithelial–mesenchymal transition by Paulo Rohan, Everton Cruz dos Santos, Pedro Leite Azevedo, Jessica Oliveira da Conceição, Eliana Abdelhay, Renata Binato

“…Experimental validation using chromatin immunoprecipitation (ChIP) assays indicated the direct and differential binding of TWIST1 and SNAI2 to the THY1 promoter, supporting their roles as key regulators of THY1 expression in GC. …”
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Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal “Heat Shock” Proteins Also “pH Shock” Resistant? by Mercede Furr, Shadi A. Badiee, Sreenivasulu Basha, Shilpi Agrawal, Zeina Alraawi, Sobroney Heng, Carson Stacy, Yeasin Ahmed, Mahmoud Moradi, Thallapuranam K. S. Kumar, Ruben Michael Ceballos

“…Structural integrity is compromised for all HSPs at ultra-low pH (e.g., pH 2). …”
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Flavonoid compound from Forsythia suspensa leaves inhibits adenovirus infection related to cell cycle based on UHPLC-Q-Exactive-Orbitrap/MS and experimental validation by Lingling Wang, Shuanshan Ren, Xingming Ma, Yanliu Li, Yongyong Zheng, Ling Li, Luhong Cao

“…In silico docking and simulation confirmed the stable binding of FSL-derived flavonoids to core cell cycle proteins. …”
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The GhANT-GoPGF module regulates pigment gland development in cotton leaves by Lu Long, Zhen-Nan Zhang, Fu-Chun Xu, Jia-Yi Ma, Shen-Zhai Shang, Hao-Ge Song, Jian-Feng Wu, Xiao-Tong Zhao, Jose Ramon Botella, Shuang-Xia Jin, Wei Gao

“…GoPGF (GOSSYPIUM PIGMENT GLAND FORMATION) is a well-characterized master transcription factor that controls gland formation in cotton; however, little is known about its transcriptional regulation. This study integrates yeast one-hybrid sequencing data and the previously reported single-cell RNA sequencing data to identify upstream GoPGF binding proteins. …”
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Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets by Hang Lei, Yimao Wu, Wenjun Ma, Jiaqi Yao, Pengcheng Zhang, Yong Tian, Yuhong Jiang, Zhijun Xie, Lv Zhu, Wenfu Tang

“…Molecular docking confirmed the strong binding between tetracycline and the core targets. …”
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Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway by Sun J, Qi X, Yang C, Wang S, Jiang J, Wang L, Song J, Yu B, Sun M

“…Molecular docking results indicated that Tan-IIA effectively binds to PI3K, AKT, and other partial core targets. …”
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Alisol Triterpenoids Exhibit Triple Modulatory Mechanisms on the Cell Membrane to Overcome Cancer Multidrug Resistance by Chen JY, Chang YT, Ho YC, Teng YN

“…Molecular docking studies revealed that B23 and A24 interact with distinct binding sites on P-gp, demonstrating allosteric and competitive inhibition.Conclusion: B23 and A24 effectively reverse cancer MDR by (1) modulating ROS levels and inducing apoptosis, (2) maintaining membrane integrity but improving membrane fluidity, and (3) inhibiting drug efflux by membrane transporters. …”
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Associations between intercurrent events and cardiorenal clinical outcomes in non-diabetic chronic kidney disease: a real-world retrospective cohort study in the United States by Christoph Wanner, Johannes Schuchhardt, Chris Bauer, Meike Brinker, Frank Kleinjung, Tatsiana Vaitsiakhovich

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Insecticide resistance in the field populations of the Asian tiger mosquito Aedes albopictus in Beijing: resistance status and associated detoxification genes by Xiaojie Zhou, Jing Li, Ruoyao Ni, Xinghui Qiu, Yong Zhang, Ying Tong

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Penfluridol suppresses MYC-driven ANLN expression and liver cancer progression by disrupting the KEAP1–NRF2 interaction by Minh Tuan Nguyen, Gi Jeong Lee, Boram Kim, Hyun Ji Kim, Jihoon Tak, Mi Kyung Park, Eun Ji Kim, Gyeoung Jin Kang, Seung Bae Rho, Ho Lee, Kyung Lee, Sang Geon Kim, Chang Hoon Lee

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Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation by Puneet Kumar, Puneet Kumar, Tusharika Kotra, Tusharika Kotra, Waseem I. Lone, Waseem I. Lone, Yassir Arfath, Yassir Arfath, Harshita Tiwari, Ashutosh Kumar Shukla, Zabeer Ahmed, Zabeer Ahmed, Sheikh Rayees, Sheikh Rayees, Jasha Momo H. Anal, Jasha Momo H. Anal

“…Colchicine binds to tubulin and destabilizes microtubules, stopping cell division and causing apoptosis. …”
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The HIF-1α/miR-145b/Angpt2 axis attenuates renal fibrosis induced by unilateral renal ischemia–reperfusion by Bingyou Cheng, Shang Huang, Lin Zhou, Pei Zhu, Zhongpu Li, Liang Hu, Jingsong Liu, Kejian Zhu

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RGS1 and CREB5 are direct and common transcriptional targets of ZNF384‐fusion proteins by Chiharu Yamada, Kentaro Okada, Koya Odaira, Mahiru Tokoro, Eisuke Iwamoto, Masashi Sanada, Mina Noura, Syuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa

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Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique by Jie Pan, Rui Wang, Wenjing Liu, Li Wang, Zhuhong You, Yuechao Li, Zhemeng Duan, Qinghua Huang, Jie Feng, Yanmei Sun, Shiwei Wang

“…In this study, we present GE-PHI, a machine-learning-based model for predicting phage-host interactions (PHIs) by integrating knowledge graph embedding algorithm with a large-scale protein language model. …”
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Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis by Shridhar Bale, Elena Gustchina, Javier Guenaga, Victor Ayala, Wen-Hsin Lee, Gabriel Ozorowski, Stephen Whitney, Richard Wilson, Sabyasachi Baboo, Jolene K. Diedrich, Esmeralda D. Doyle, Lauren Hudacik, Elana Ben-Akiva, Kristen A. Rodrigues, Darrell J. Irvine, John R. Yates, James C. Paulson, Andrew B. Ward, Timothy Fouts, Richard T. Wyatt

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A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages by Nils Schmerer, Harshavardhan Janga, Michelle Aillaud, Janina Hoffmann, Marina Aznaourova, Sarah Wende, Henrike Steding, Luke D. Halder, Michael Uhl, Fabian Boldt, Thorsten Stiewe, Andrea Nist, Lukas Jerrentrup, Andreas Kirschbaum, Clemens Ruppert, Oliver Rossbach, Evgenia Ntini, Annalisa Marsico, Chanil Valasarajan, Rolf Backofen, Uwe Linne, Soni S. Pullamsetti, Bernd Schmeck, Leon N. Schulte

“…Here we develop GRADR, a method integrating gradient profiling with RNA-binding proteome analysis, to map the protein interactomes of all expressed RNAs in a single experiment to study mechanisms of lncRNA-mediated regulation of human primary macrophages. …”
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FtsZ as a novel target for antibiotics development: Promises and challenges by Ming-Wei Wang, Kaini Hang, Wei Han, Xin Li, Qingtong Zhou, Dehua Yang

“…However, clinical translation is hindered by weak binding affinities, inhibitory inefficacy, dynamic conformational flexibility, and evolving drug resistance linked to FtsZ's functional plasticity. …”
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