Investigating the Effects of Gossypetin on Liver Health in Diet-Induced Pre-Diabetic Male Sprague Dawley Rats by Karishma Naidoo, Andile Khathi

“…Liver histology in the GTIN-treated groups revealed decreased lipid droplet accumulation and improved tissue integrity. Similar results were observed for the liver parameters in the MET-treated groups. …”
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A Randomized, Double-Blind, Placebo-Controlled Trial Protocol Using the Fuzhengxiaoliu Patch for the Management of Primary Liver Cancer Pain by Li S, Wang B, Deng J, Li H, Wu Y, Fang Y, Yan B, Chen Y

“…Adverse events (AEs) will be recorded throughout the study.Discussion: This study integrated TCM with clinical research to assess the efficacy and safety of the addition of FZXLP in the treatment of primary liver cancer pain.Trial registration: Chinese clinical trial registry, ChiCTR2300076951, Registered on October 25, 2023. https://www.chictr.org.cn/showproj.html?…”
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L‐quebrachitol Modulates the Anti‐convulsant Effects of Carbamazepine Possibly Through Voltage‐gated Sodium Channel Blocking Mechanism in Chicks: In Vivo and In Silico Studies... by Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam

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Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement by Oliver J. Gerken, Nicola Catone, Daniel F. Legler

“…Conclusion This study identifies that the integrity of the C-terminus of ACKR4 is critical for receptor function. …”
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Synergistic optimization enhancing the precision and efficiency of cytosine base editors in poplar by Han Liu, Mengyu Zhang, Leiqian Sun, Yu Peng, Yu Sun, Yawei Fan, Hui Li, Di Liu, Hai Lu

“…To address these limitations, we engineer a high-efficiency poplar CBE system (hyPopCBE) by integrating the MS2-UGI system, fusing Rad51 DNA-binding domain, and modifying the nuclear localization signal. …”
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Maladaptive state reinforcement of greenspace in racially marginalized neighborhoods: lessons from Louisville, Kentucky’s failed cooperative extension partnership by Daniel A DeCaro, Emmanuel Frimpong Boamah, Mary A Rudolph, Gifty Amma Adusei

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Bletilla striata polysaccharides ameliorate metabolic-associated fatty liver disease by decreasing the NLRP3 inflammasome and pyroptosis by Tingting Yu, Juan Xue, Wenqian Tang, Xiaojie Wu, Jun Li, Fan Yang, Lei Luo

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Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis by Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning

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Elucidating Molecule-Crosstalk of Neutrophil Extracellular Traps Between Cardiovascular Disease and Psoriasis: Insights Into Mendelian Randomization, Single-Cell RNA Analysis, Shar... by Jin X, Zhang Y, Qin G, Fang X, Zhang X, Sun J, Zhou M, Tong X, Xue Y, Yang H, Tian W

“…Neutrophil extracellular traps (NETs) are implicated in both conditions, but the mechanisms remain unclear.Methods: We integrated bulk and single-cell RNA sequencing, mendelian randomization, immune microenvironment analysis, and molecular docking to explore the molecular interactions between LVH and PSO, focusing on NET-related pathways. …”
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Generation of a transgene-free Induced pluripotent stem (iPS) cell line (JNCHi002-A) from a female heterozygous carrier of the low density lipoprotein receptor (LDLR) gene mutation... by Rujin Tian, Yixiao Li, Hongmei Xin, Yue Jiang, Haozheng Zhang, Lin Zhong, Zhongtao Gai, Qianqian Deng, Chunhui Wang, Kaihui Zhang

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ROLE OF BUSINESS GAME IN THE FORMATION OF CLINICAL THINKING AND COMMUNICATION SKILLS OF FUTURE DENTISTS by I.V. Gorb-Gavrilchenko

“…Analysis of it is being widely introduced in the example of the decision of situational problems. Another way of binding is a clinical examination of the patient. …”
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Prophylactic Treatment of Probiotic and Metformin Mitigates Ethanol-Induced Intestinal Barrier Injury: In Vitro, In Vivo, and In Silico Approaches by Farhin Patel, Kirti Parwani, Priyashi Rao, Dhara Patel, Rakesh Rawal, Palash Mandal

“…Ethanol depletes intestinal integrity and promotes gut dysbiosis. Studies have suggested the individual role of probiotics and metformin Met in protecting intestinal barrier function from injuries induced by ethanol. …”
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MCPIP3 orchestrates the balance of epidermal proliferation and differentiation by Agata Lichawska-Cieslar, Weronika Szukala, Pawel Pilat, Leopold Eckhart, Jacek C Szepietowski, Jolanta Jura

“…The expression levels of keratinocyte proliferation and differentiation markers, such as keratin-14, cyclin B1, involucrin, and the S100 calcium-binding proteins S100A7/A9, were increased in NHEKs in which MCPIP3 expression was silenced. …”
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Distributed representations enable robust multi-timescale symbolic computation in neuromorphic hardware by Madison Cotteret, Hugh Greatorex, Alpha Renner, Junren Chen, Emre Neftci, Huaqiang Wu, Giacomo Indiveri, Martin Ziegler, Elisabetta Chicca

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A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD) by Bei Wang, Fan Zhu, Yingying Chen

“…Abstract Introduction Guanine nucleotide-binding protein alpha inhibiting activity polypeptides (GNAI1, GNAI2, and GNAI3) play critical roles in cell cycle regulation, intracellular signaling, and immune modulation. …”
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Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. by Matias Escobar-Aguirre, Hong Zhang, Allison Jamieson-Lucy, Mary C Mullins

“…We thus tested if Macf1a functions via its actin binding domain (ABD) and plectin repeat domain (PRD) to integrate cortical actin and Bb CK, respectively, to mediate Bb dissociation at the oocyte cortex. …”
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miR-184, a downregulated ovary-elevated miRNA transcriptionally activated by SREBF2, exerts anti-apoptotic properties in ovarian granulosa cells through inducing SMAD3 expression by Baosen Shan, Yangan Huo, Zhennan Guo, Qiqi Li, Zengxiang Pan, Qifa Li, Xing Du

“…Mechanistically, miR-184 induced SMAD3 transcription by acting as a saRNA, and also stabilized SMAD3 mRNA by directly binding to its 5′-UTR, which promoted TGF-β pathway activity and its anti-apoptotic effect. …”
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Machine Learning-Driven Identification of Exosome-Related Genes in Head and Neck Squamous Cell Carcinoma for Prognostic Evaluation and Drug Response Prediction by Hua Cai, Liuqing Zhou, Yao Hu, Tao Zhou

“…<b>Background:</b> This study integrated four Gene Expression Omnibus (GEO) datasets to identify disease-specific feature genes in head and neck squamous cell carcinoma (HNSCC) through differential expression analysis with batch effect correction. …”
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RBBP6‐Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease by Hongtu Hu, Jijia Hu, Zhaowei Chen, Keju Yang, Zijing Zhu, Yiqun Hao, Zongwei Zhang, Weiwei Li, Zhuan Peng, Yun Cao, Xiaoling Sun, Fangcheng Zhang, Qingjia Chi, Guohua Ding, Wei Liang

“…Estrogen‐related receptor α (ERRα) is essential for mitochondrial integrity in PTCs, yet its regulation in DKD is poorly understood. …”
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Therapeutic Effects and Mechanisms of the Inhaled Traditional Chinese Medicine Compound ZHW on Allergic Rhinitis by Yujin Shen, Xi Ma, Zhenzhen Du, Yang Li, Zhinan Mei, Ling Zhao

“…Furthermore, the underlying mechanisms and potential targets of ZHW were investigated through integrated network pharmacology and proteomics analyses. …”
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