Limosilactobacillus reuteri enables oral-to-systemic absorption of iberiotoxin for treatment of collagen-induced arthritis in rats by Mohamed R. Kady, R. Nicholas Elston, Lauren J. Snyder, Jorie D. Fleischman, Madilyn J. Brandt, Duolong Zhu, Robert A. Britton, Christine Beeton

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Sustainable synthesis of bakuchiol-mediated gold nanoparticles for drug delivery against bacterial strains and tumor microenvironments, and its in silico target proteins identifica... by Pooja Mishra, Tabrez Faruqui, Sheeba Khanam, Mohd Khubaib, Irfan Ahmad, Mohd Saeed, Salman Khan

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Blood–Brain Barrier Dysfunction Predicts Microglial Activation After Traumatic Brain Injury in Juvenile Rats by Tabitha R.F. Green, Tina Nguyen, Veronika Dunker, Danielle Ashton, J. Bryce Ortiz, Sean M. Murphy, Rachel K. Rowe

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Dual spatial region flexible chlorine based ionic hypercrosslinked polymer synergistically adsorb formaldehyde and carbon dioxide by Wang Ruimeng, Xie Yawei, Zhao Zhongxing, Zhao Zhenxia

“…Through the ordered self-assembly of ionic monomers, the array-distributed free Cl, terminal Cl, and pyrrole nitrogen (N) sites were integrated into the skeletal network of Cl-IHCP and formed ultra-microporous environment with two different adsorption regions. …”
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Development of a Predictive Model for the Biological Activity of Food and Microbial Metabolites Toward Estrogen Receptor Alpha (ERα) Using Machine Learning by Maksim Kuznetsov, Olga Chernyavskaya, Mikhail Kutuzov, Daria Vilkova, Olga Novichenko, Alla Stolyarova, Dmitry Mashin, Igor Nikitin

“…These results underscore the promising potential of integrating predictive modeling into food technology and highlight the need for further experimental validation and model refinement to support innovative strategies for developing healthier and more sustainable food products.…”
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Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha by Shilong Jiang, Keyi Liu, Ting Jiang, Hui Li, Xiao Wei, Xiaoya Wan, Changxin Zhong, Rong Gong, Zonglin Chen, Chan Zou, Qing Zhang, Yan Cheng, Dongsheng Cao

“…Subsequent validation via surface plasmon resonance, biotin pulldown, and thermal shift assays confirms Bufalin’s direct binding to ESR1, which encodes estrogen receptor alpha (ERα). …”
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Exploration of Carbon Emission Reduction Pathways for Urban Residential Buildings at the Provincial Level: A Case Study of Jiangsu Province by Jian Xu, Tao Lei, Milun Yang, Huixuan Xiang, Ronge Miao, Huan Zhou, Ruiqu Ma, Wenlei Ding, Genyu Xu

“…However, less developed northern regions emerge as binding constraints, requiring technology investments. …”
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Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins by Daniel R. Fox, Kazem Asadollahi, Imogen Samuels, Bradley A. Spicer, Ashleigh Kropp, Christopher J. Lupton, Kevin Lim, Chunxiao Wang, Hari Venugopal, Marija Dramicanin, Gavin J. Knott, Rhys Grinter

“…Pathogenic E. coli and Shigella spp. produce the outer membrane transporter ChuA, which binds host hemoglobin and extracts its heme cofactor, before importing heme into the cell. …”
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Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion by Magdalena Ponce de León, Matej Murgaš, Leo R Silberbauer, Marcus Hacker, Gregor Gryglewski, Andreas Hahn, Rupert Lanzenberger

“…Method 2 replaced the post-dose placebo equilibrium period with the pre-dose citalopram equilibrium period. Method 3 integrated aspects of both Methods 1 and 2, utilizing BPND and the pre-dose citalopram equilibrium phase. …”
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Targeting Streptococcus pyogenes atpF protein for multi-epitope vaccine development: a genomics-driven immunoinformatics strategy by Manisha Agarwal, Sanjeeb Handique, Sanchaita Rajkhowa, Abhichandan Das, Debashis Panda, Sami A. Al-Hussain, Magdi E.A. Zaki

“…Three vaccine constructs (SM1, SM2, and SM3) were designed by integrating antigenic B-cell and T-cell epitopes with immune-modulating adjuvants and linkers. …”
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The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review by Shuangyu Chen, Wenqian Chen, Tinghui Xu, Jiayang Li, Jianghao Yu, Yibo He, Shengliang Qiu

“…In conclusion, lipid metabolic reprogramming represents a promising yet underexplored axis in modulating antitumor immunity in GC. Integrating metabolic intervention with immunotherapy holds potential to overcome current treatment limitations and improve clinical outcomes. …”
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Comparative metabolome and transcriptome revealed the CpODO1 transcription factor controlling the varied floral scent traits of three wintersweet cultivars by Yubing Yong, Qi Zhou, Xin Ding, Jianming Cheng, Chengcheng Zhou, Zhiguo Shen, Lin Zhang

“…The identification of polymorphisms in the MYB binding cis-motifs of CpCYP71 and CpODO1 promoters revealed the regulatory mechanism underlying the varied synthesis of benzyl alcohol in three wintersweet cultivars. …”
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In silico evaluation of guarana's bioactive compounds for diabetes, inflammation, and oxidative stress: Insights from molecular docking and ADMET profiling by Effaliza Misran, Fitrien Husin, Alia Natasha Sa'at, Amirah Qistina Harun, Saiful Irwan Zubairi, Harisun Ya'akob

“…Theobromine also exhibited a noteworthy binding affinity for NOX (−4.0 kcal/mol), indicating antioxidant capabilities. …”
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Dual therapeutic potential of Scoparia dulcis in combating hyperglycemia and inflammation in diabetes through network pharmacology and in silico analysis by Ngoc-Thac Pham, Huong-Giang Le, Thuy-Tien Thi Phan, Phuong Vu Luu, Bo-Rong Peng, Lo-Yun Chen, Yu-Chia Chang, Kuei-Hung Lai

“…Molecular docking followed by 200 ns molecular dynamics simulations assessed the binding affinity of TNF-α with the top ten selected compounds, revealing strong and stable interactions with essential active site residues. …”
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Advances in Forensic Entomotoxicology for Decomposed Corpses: A Review by Sen Hou, Zengjia Liu, Jiali Su, Zeyu Yang, Zhongjiang Wang, Xinyi Yao, Zhou Lyu, Yang Xia, Shuguang Zhang, Wen Cui, Yequan Wang, Lipin Ren

“…Key components such as <i>cytochrome P450 monooxygenases</i> (<i>P450s</i>), <i>glutathione S-transferases</i> (<i>GSTs</i>), and <i>ATP-binding cassette</i> (<i>ABC</i>) transporters play essential roles in xenobiotic metabolism and insecticide resistance. …”
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Glucagon-Like Peptide-1 Receptor Agonists in Obesity Management: Mechanisms, Efficacy, and Safety by Michał Stasiak, Wiktor Żyro, Karolina Woźniak, Katarzyna Żyro, Franciszek Glapiński, Adam Woźniak

“…Overall, GLP-1 RAs represent a significant advancement in obesity pharmacotherapy by integrating appetite suppression, delayed gastric emptying, and metabolic improvements. …”
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In silico screening and experimental validation identify riboflavin as an RNA-targeted antiviral against SARS-CoV-2 by Chae-Hong Jeong, Yoo Jin Na, Tae Yong Kim, So Young Lee, Jungyeon Kim, Sangmi Ryou

“…This study established a framework for integrating computational and experimental methods to identify conserved RNA targets, thus offering a strategy applicable to other RNA viruses. …”
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Formulation development of a stable influenza recombinant neuraminidase vaccine candidate by Bing Li, Irina V. Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y. Y. Fung, Guadalupe Cortés, D. Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H. Brookes, Salvador F. Ausar

“…The study highlights the importance of understanding and controlling vaccine protein structural and functional integrity.…”
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Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb by Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson

“…The clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. …”
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Snap and detect: smartphone-enabled paper-based colorimetric tool for nucleic acid sequence-specific analysis by Panagiota M Kalligosfyri, Valentina Arciuolo, Antonella Miglione, Jussara Amato, Bruno Pagano, Stefano Cinti

“…TATA-containing sequences induced a blue color shift upon dye binding, with intensity correlating to target concentration. …”
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