Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

Get full text

Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity by Heng Yin, Meng Liu, Yaling Zhao, Haitao Wu, Danna Zheng, Zhenhui Guo, Ying Zhou, Shaofeng Wu, Chuanbing Chen, Lei Zhang, Shanshan Song, Yanli He, Ren Zhang

Get full text

Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…Recombinase A (RecA) and the transcriptional repressor LexA are the key players that orchestrate this process, determining either the silencing or the active transcription of the genes under their control. By integrating state-of-the-art structural approaches with in vitro binding and functional assays, we elucidated the molecular events activating the SOS response in P. aeruginosa, focusing on the RecA-LexA interaction. …”
Get full text

Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels... by Yves Renaudineau, Amandine Charras, Valentina Natoli, Nicolas Congy-Jolivet, Sam Haldenby, Xuan Liu, Yongxiang Fang, Eve MD. Smith, Michael W. Beresford, Christian M. Hedrich, Carla Roberts, Eslam Al-Abadi, Kate Armon, Kathryn Bailey, Coziana Ciurtin, Janet Gardner-Medwin, Kirsty Haslam, Daniel P. Hawley, Alice Leahy, Valentina Leone, Flora McErlane, Gita Modgil, Clarissa Pilkington, Athimalaipet V. Ramanan, Satyapal Rangaraj, Phil Riley, Arani Sridhar

“…Considering ancestral variation, clinical associations were tested at the level of alleles (2-field resolution), associated HLA protein sequences (antigen binding domains, 4-field resolution), and extended haplotypes (DRh). …”
Get full text

The Role of miRNA in Plant Adaptation to Abiotic Stress by Mohammad Hadi Taleb, Ahmad Arzani

“…Then, a specific guide strand is chosen and integrated into the RNA-induced silencing complex (RISC). …”
Get full text

USP37 prevents premature disassembly of stressed replisomes by TRAIP by Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson

“…Finally, guided by AlphaFold-Multimer, we discovered that binding to CDC45 mediates USP37’s response to topological stress. …”
Get full text

The role of the striatin family proteins in hippo signaling and cellular regulation by Yarden Shor-Nareznoy, Michal Caspi, Yan Lender, Amnon Wittenstein, Arad Soffer, Hanin Elias, Natalie Zelikson, Rana Masri, Rose Jbara, David C. Pallas, Metsada Pasmanik-Chor, Chen Luxenburg, Rina Rosin-Arbesfeld

“…Abstract The striatin family proteins, striatin, SG2NA, and zinedin, belong to the calmodulin-binding WD-40 repeat protein group and are components of the striatin interacting phosphatase and kinase (STRIPAK) complex. …”
Get full text

p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance by Ai Tamura, Kazuyuki Yamagata, Takashi Kono, Masanori Fujimoto, Takahiro Fuchigami, Motoi Nishimura, Masataka Yokoyama, Akitoshi Nakayama, Naoko Hashimoto, Ikki Sakuma, Nobuyuki Mitsukawa, Yusuke Kawashima, Osamu Ohara, Shinichiro Motohashi, Eiryo Kawakami, Takashi Miki, Atsushi Onodera, Tomoaki Tanaka

“…Additionally, LOC644656 mitigates DNA damage by binding DNA-PKcs and modulating the DNA damage response. …”
Get full text

Unveiling the Neighboring Screening Effect and Strong p‐d Coupling in CO2 Reduction on Graphene‐Supported Metal‐Free and Iron Phthalocyanine by Zikang Li, Ziqi Zhou, Mingzi Sun, Tong Wu, Qiuyang Lu, Lu Lu, Baian Chen, Cheuk Hei Chan, Hon Ho Wong, Bolong Huang

“…The screening shielding effect arising from the strong p‐d coupling of the FeN binding is observed on the 2nd nearest neighboring site, thus, suppressing the neighboring effect. …”
Get full text

Virtual screening, molecular dynamics simulations, and in vitro analysis of Sophora flavescens-derived aloperine against Haemonchus contortus by Anben Li, Anben Li, Yan Ma, Yan Ma, Wenxi Li, Bintao Zhai, Nana Fu, Nana Fu, Jun Li, Jun Li, Qianyu Zhou, Yang Liu, Yang Liu

“…Further evaluation through larval development test (LDT), larval migration inhibition test (LMIT), and scanning electron microscopy revealed that the combined administration of ALO and IVM exerted significantly enhanced inhibitory effects on the development, motility, and morphological integrity of IVM-resistant strains compared to monotherapy groups. …”
Get full text

Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy by Vinicius da Cruz Neris Geßner, Vinicius da Cruz Neris Geßner, Janis Theobald Linke, Janis Theobald Linke, Thomas-Otavio Peulen, Luise Appeltshauser, Claudia Sommer, Dirk Brämer, Christian Geis, Katrin Gertrud Heinze, Kathrin Doppler

“…Understanding the impact of autoantibody binding on protein assembly is crucial for gaining insights into the pathogenicity of different autoantibodies. …”
Get full text

ACtriplet: An improved deep learning model for activity cliffs prediction by in tegrating triplet loss and pre-training by Xinxin Yu, Yimeng Wang, Long Chen, Weihua Li, Yun Tang, Guixia Liu

“…Activity cliffs (ACs) are generally defined as pairs of similar compounds that only differ by a minor structural modification but exhibit a large difference in their binding affinity for a given target. ACs offer crucial insights that aid medicinal chemists in optimizing molecular structures. …”
Get full text

Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus by Ritian Jin, Guanglei Wei, Rong Lin, Wenfeng Lin, Jude Juventus Aweya, Duo Liang, Wuyin Weng, Shen Yang

“…Molecular docking experiments further verified the binding sites of FAM286 to S. aureus biofilm proteins SarA, AgrA, and Hld. …”
Get full text

AKR1C3 enhances radioresistance in esophageal adenocarcinoma via inhibiting ferroptosis through suppressing TRIM21-mediated ubiquitination of HSPA5 by Feng Ju, Jialei Weng, Ningbo Fan, Zhefang Wang, Chenghui Zhou, Xinlei Zhao, Nellie Horstmann, Xiaolin Wu, Sascha Hoppe, Bo You, Keying Li, Jianxin Duan, Margarete Odenthal, Axel M. Hillmer, Alexander Quaas, Christiane J. Bruns, Yue Zhao

“…Mechanistically, AKR1C3 binds to the nucleotide-binding domain of HSPA5, thereby inhibiting the E3 ligase TRIM21-induced ubiquitin-dependent proteasomal degradation of HSPA5, which further stabilizes GPX4, thus inhibiting ferroptosis. …”
Get full text

<i>Bacillus</i><i> thuringiensis</i> Exopolysaccharide BPS-2 Ameliorates Ulcerative Colitis in a Murine Model Through Modulation of Gut Microbiota and Suppression of the NF-κB Casc... by Zexin Gao, Huan Li, Jungang Wen, Wenping Ding, Jie Yu, Yue Zhang, Xiaojuan Song, Jianrong Wu

“…Molecular docking analysis displayed strong binding affinity (ΔG = −7.8 kcal/mol) between the BPS-2U fragment and the Nuclear Factor κB (NF-κB) p50/p65 heterodimer, suggesting the potential disruption of NF-κB signaling pathways. …”
Get full text

Dealkylation metabolites of Atrazine: A previously Neglected Contributor to soybean phytotoxicity within atrazine residue by Nan Wang, Yabo Liang, Wangjing Zhai, Fanrong Zhao, Li Zheng, Peng Wang, Zhiqiang Zhou, Xueke Liu, Donghui Liu

“…Molecular docking analysis revealed that both DEA and DIA exhibited high binding energies with Photosystem II D1 protein, with their potential target protein in soybean plants being consistent with that of atrazine. …”
Get full text

Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism by Xiao-Qing Song, Tian-Jian Yu, Yang Ou-Yang, Jia-Han Ding, Yi-Zhou Jiang, Zhi-Ming Shao, Yi Xiao

“…LSD1 subsequently promotes the expression of sterol regulatory element-binding protein 1 (SREBP1) by demethylating dimethyl histone H3 lysine 9 (H3K9me2). …”
Get full text

The Primary Cilia are Associated with the Axon Initial Segment in Neurons by Han Wang, Yu Li, Xin Li, Zehui Sun, Fengdan Yu, Abolghasem Pashang, Don Kulasiri, Hung Wing Li, Huan Chen, Hongwei Hou, Yan Zhang

“…The findings elucidate a specific interaction between the primary cilia and AIS, providing insight into the impact of the primary cilia on neuronal excitability and circuit integrity.…”
Get full text

Optimization of methanol‐induced expression and His‐tag purification of Saccharomycopsis fibuligera R64 mutant α‐amylase in Pichia pastoris by Clara Claudia, Elsa Destiana, Rista Awalia, Mia Tria Novianti, Taufik Ramdani Tohari, Dewi Astriany, Shinta Kusumawardani, Muhammad Yusuf, Umi Baroroh

“…The native conditions retained higher protein integrity and activity, while the denaturing process resulted in partial degradation. …”
Get full text

An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli by Irina Kalita, Ira Alexandra Iosub, Lorna McLaren, Louise Goossens, Sander Granneman, Meriem El Karoui

“…Furthermore, specific disruption of the Hfq-binding site leads to more efficient translation of recB mRNAs. …”
Get full text