An In Silico Approach to Discover Efficient Natural Inhibitors to Tie Up Epstein–Barr Virus Infection by Ayan Das, Mumtaza Mumu, Tanjilur Rahman, Md Abu Sayeed, Md Mazharul Islam, John I. Alawneh, Mohammad Mahmudul Hassan

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Revealing the multi-target compounds of Sarcandra glabra identification and inhibition of novel target genes for the treatment of pancreatic cancer by Xing Liu, Jianghong Ou

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A Prediction Model for Sight-Threatening Diabetic Retinopathy Based on Plasma Adipokines among Patients with Mild Diabetic Retinopathy by Yaxin An, Bin Cao, Kun Li, Yongsong Xu, Wenying Zhao, Dong Zhao, Jing Ke

“…In both training and testing sets, involving 306 patients with T2DM, median levels of plasma adiponectin (APN), leptin, and fatty acid-binding protein 4 (FABP4) were significantly higher in the STDR group than those in mild NPDR. …”
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The Role of External Signs of Multi-volume Editions in the Reconstruction of Kolyvan-Voskresensky Mining Plants Book Collection by T. N. Ilyushechkina

“…In some cases the paramount importance of the binding characteristics is shown. The role of external signs in combining disparate copies as sets of multi-volume editions is recognized as leading. …”
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SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide... by Lei L Chen, Jing Zhu, Jonathan Schumacher, Chongjuan Wei, Latha Ramdas, Victor G Prieto, Arnie Jimenez, Marco A Velasco, Sheryl R Tripp, Robert H I Andtbacka, Launce Gouw, George M Rodgers, Liansheng Zhang, Benjamin K Chan, Pamela B Cassidy, Robert S Benjamin, Sancy A Leachman, Marsha L Frazier

“…It involves: (1) SCF-expressing cells communicate with neighboring KIT-expressing cells directly or indirectly (cleaved soluble SCF). (2) SCF-KIT signaling induces timely local ET3 synthesis and secretion. (3) ET3 binds to ETBR on both sides of intercellular space. (4) ET3-binding-initiated-ETBR activation increases cytosolic Ca2+, activates cell-specific eNOS or nNOS. (5) Temporally- and spatially-precise NO generation. …”
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Network toxicology and bioinformatics analysis reveal the molecular mechanisms of polyethylene terephthalate microplastics in exacerbating diabetic nephropathy by Shengnan Zeng, Hui Guo

“…However, the molecular mechanisms linking PET-MP exposure to DN remain unclear. This study integrates network toxicology and bioinformatics to explore PET-MP-induced nephrotoxicity in DN. …”
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Harnessing Jasmonate Pathways: PgJAR1’s Impact on Ginsenoside Accumulation in Ginseng by Ru Zhang, Chao Li, Rui Guo, Zhaoying Li, Bianling Zhang

“…Jasmonates (JAs), a class of stress-induced phytohormones, are integral in modulating plant defense responses and the biosynthesis of secondary metabolites, including ginsenosides. …”
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Exploring the interplay between LDHA and ABCC1 in breast cancer using computational approach by Bader Alshehri

“…Chemoresistance is significantly mediated by drug efflux transporters, including ATP-binding cassette transporter ABCC1, and glycolytic enzymes, especially lactate dehydrogenase A (LDHA). …”
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Ionic liquid-assisted seed genomic DNA extraction for advanced sequencing applications by Shashini De Silva, Philip C. Bentz, Cecilia Cagliero, Morgan R. Gostel, Gabriel Johnson, Jared L. Anderson

“…The IL-method was benchmarked against a silica-binding method using cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) as lysis agents using a commercial plant DNA extraction kit in terms of DNA yield, purity, abundant DNA fragment size distribution, and integrity. …”
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What Is New for the Mechanisms of Plant Resistance to Paraquat After Decades of Research? by Liyun Zhang, Chang Xu, Heping Han, Shawn Askew, Erik Ervin, Qin Yu, Kehua Wang

“…In addition, the evolving perspectives in paraquat resistance research integrating big data and artificial intelligence, development of paraquat-tolerant crops, and a proposal of ryegrass (<i>Lolium.…”
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Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population by Yi Mo, Fangfang Liang, Arshad Mehmood, Suleman Shah, Ying Xie, Zhong Lin, Yan Sun, Hesheng Jiang, Yafen Guo, Xiangli Niu, Dinggan Mo

“…This study reveals a possible association between the Gln223Arg polymorphism of the LEPR gene in spermatozoa affecting spermatozoal membrane integrity and having a direct role in sperm motility.…”
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Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines. by Orit Gat, James E Galen, Sharon Tennant, Raphael Simon, William C Blackwelder, David J Silverman, Marcela F Pasetti, Myron M Levine

“…We speculate that an excess of IgG1 anti-FliC antibodies induced by the exported FliC may compete with the IgG2a subtype and block binding to specific phagocyte Fc receptors that are critical for clearing an S. …”
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2,2&rsquo;- Bipyridine Derivatives Exert Anticancer Effects by Inducing Apoptosis in Hepatocellular Carcinoma (HepG2) Cells by Priyanka, Mujwar S, Bharti R, Singh TG, Khatri N

“…Docking studies revealed interactions between the derivatives and the signaling proteins AKT (PDB ID: 6HHF) and BRAF (PDB ID: 8C7Y) with binding affinities ranging from − 7.10 to − 9.91, highlighting their pivotal role in targeting key players in hepatocellular carcinoma progression.Conclusion: The findings of this study underscore the therapeutic potential of these derivatives against HepG2 cells and offer valuable insights for further experimental validation of their efficacy as inhibitors targeting AKT or BRAF signaling pathways. …”
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Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches by Tuncay Sahutoglu, Mark A. Perazella

“…Among these, the urinary CXCL9-to-creatinine ratio demonstrates high sensitivity and specificity, with well-defined thresholds guiding clinical decisions. Urinary retinol-binding protein and serum C-reactive protein (CRP) have also been explored, particularly in immune checkpoint inhibitor (ICPI)-associated AKI. …”
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The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease by Mengyun Yue, Tingtao Chen, Wenjie Chen, Jing Wei, Bin Liao, Jie Zhang, Fangjun Li, Daojun Hong, Xin Fang

“…Additionally, Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide, lipopolysaccharide binding protein, interleukin-1β, and interleukin-6. …”
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One-pot synthesis of quercetin-functionalized silver and copper nanoparticles for enhanced optical, antimicrobial, and computational properties by Dara Muhammed Aziz, Alla Ahmed Muhammed Amin, Sangar Ali Hassan, Habibe Özmen, Gökhan Kursad INCILI, Yakup Say

“…In silico docking against the S. epidermidis TcaR regulator (PDB: 1KZN) and E. coli DNA gyrase B (PDB: 1HSK) revealed strong binding affinities (–7.54 to − 10.15 kcal·mol⁻¹), consistent with the observed antimicrobial potency. …”
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Exploring the anticonvulsant potential of Daucus carota L.: A combined in silico and in vivo study for epilepsy therapy development by Naznin Sarkar, Anil Kumar Venkategowda Kodihally, Akshay Shamnewadi

“…Results: Molecular docking revealed significant binding affinities for apigenin (-6.7 kcal/mol) and luteolin (-6.6 kcal/mol) with GABRA1, suggesting their potential to enhance GABAergic signaling. …”
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The euchromatic histone mark H3K36me3 preserves heterochromatin through sequestration of an acetyltransferase complex in fission yeast by Paula R. Georgescu, Matías Capella, Sabine Fischer-Burkart, Sigurd Braun

“…Maintaining the identity of chromatin states requires mechanisms that ensure their structural integrity through the concerted actions of histone modifiers, readers, and erasers. …”
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HBs antigen and mannose loading on the surface of iron oxide nanoparticles in order to immuno-targeting: fabrication, characterization, cellular and humoral immunoassay by Mahsa Rezaei, Seyed Nezamedin Hosseini, Ramazan Ali Khavari-Nejad, Farhood Najafi, Mehdi Mahdavi

“…The synthesized nano-vaccine showed spherical shape with a mean particle size of 60 nm, a zeta potential of −44 mV, an antigen-binding efficiency of around 100% and for mannose 78%. …”
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In vitro and in silico evaluation of phytocompounds from Leucaena leucocephala and Entada phaseoloides targeting DNA gyrase, topoisomerase II, AKT1 by Laldinliana Khiangte, Hmingremhlua Sailo, Laldinfeli Ralte, F. Lalnunmawia, N. Senthilkumar, Yengkhom Tunginba Singh

“…In silico ADMET profiling, molecular docking, and molecular dynamics simulations identified key bioactive compounds with strong binding affinities toward Topoisomerase II, DNA gyrase, and AKT1. …”
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