Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes by Md Kamrul Hasan, L. Jeannine Brady

“…K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence protein–protein interactions of proteins that harbor them, and are found in all kingdoms of life. …”
Get full text

Computational Investigation of Electronic Properties and Transmission Coefficient in AA-Stacked Bilayer Graphene Using the Nearest-Neighbour Tight-Binding Model by Yuki Wong, Nurul Ezaila Alias, Tian Swee Tan, Cheng Siong Lim, Michael Loong Peng Tan

“…This study employed a tailored nearest-neighbour tight-binding (NNTB) model for comprehensively investigating these electronic characteristics. …”
Get full text

OnmiMHC: a machine learning solution for UCEC tumor vaccine development through enhanced peptide-MHC binding prediction by Fangfang Jian, Haihua Cai, Qushuo Chen, Xiaoyong Pan, Weiwei Feng, Ye Yuan, Ye Yuan

“…These results demonstrate the superiority of our model OnmiMHC in accurately predicting peptide-MHC binding affinities across both MHC-I and MHC-II molecules. …”
Get full text

Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice. by Florence Njau, Nelli Shushakova, Heiko Schenk, Vera Christine Wulfmeyer, Robin Bollin, Jan Menne, Hermann Haller

“…However, VEGF is needed at physiological concentrations to maintain glomerular integrity; complete VEGF blockade has deleterious effects on glomerular structure and function. …”
Get full text

Escherichia coli proteins uL29 and ACP stabilize the Tn7-encoded TnsD and its DNA binding by Shani B. Leyva Camacho, Lindsay A. Matthews, Alba Guarné

“…In the case of the CRISPR-associated Tn7 elements from the type V-K, the ribosomal protein uS15 is an integral component of recruitment complex that promotes R-loop completion. …”
Get full text

Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations by Lin-jian Wang, Lin-jian Wang, Lin-jian Wang, Yangyang Wu, Yangyang Wu, Yangyang Wu, Sha Xie, Hongkai Lian, Hongkai Lian, Hongkai Lian

Get full text

Parallel Changes in Harvey-Bradshaw Index, TNFα, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn’s Disease by Anas Kh. Al-Saffar, Carl Hampus Meijer, Venkata Ram Gannavarapu, Gustav Hall, Yichen Li, Hetzel O. Diaz Tartera, Mikael Lördal, Tryggve Ljung, Per M. Hellström, Dominic-Luc Webb

“…Intestinal fatty acid binding protein (I-FABP) indicates barrier integrity. …”
Get full text

Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Notably, integrated transcriptomic and rescue experiments revealed that LINC00339 and PARP1 coregulate CDC42 expression through post-transcriptional regulatory mechanisms. …”
Get full text

MENGENAL MEDIASI SEBAGAI SALAH SATU CARA PENYELESAIAN SENGKETA by Siti Nur Azizah, Wagiman, Adrian Bima Putra

Get full text

Antiviral activity of eicosapentaenoic acid against zika virus and other enveloped viruses by Yifei Feng, Yifei Feng, Shuqi Qiu, Shuting Zou, Ru Li, Hongyu Chen, Kaitian Chen, Junbo Ma, Jinyu Liu, Xiaoyun Lai, Shuwen Liu, Shuwen Liu, Min Zou, Min Zou

“…Mechanistic experiments showed that EPA disrupted the membrane integrity of viral particles, leading to the release of viral RNA, together with the interruption of ZIKV from binding, adsorption and entry, and ultimately the inhibition of viral proliferation. …”
Get full text

Effect of the recombinant amelogenin peptide TRAP on remineralization of early enamel caries: an in-situ study by Qinghua Bai, Yaru Li, Mingzhu Wen, Dandan Ma, Yiwei Li, Jinpu Chu

“…At the end of each treatment period, the percentage of surface microhardness recovery (%SHR) and the integrated change in subsurface hardness (%ΔIHC) were evaluated. …”
Get full text

Correlation Analysis Between 3D and Plane DAT Binding Parameters of 11C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson’s Disease by Xiaodong Wu, Ziyuan Li, Jing Gan, Feng Wei, Ping Wu, Sheng Liang, Yufei Ma, Lin Ding, Chuantao Zuo, Zhenguo Liu, Hui Wang, Yafu Yin

“…Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD. …”
Get full text

In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins by Shinichi Kawaguchi, Xin Xu, Takashi Soga, Kenta Yamaguchi, Ryuuya Kawasaki, Ryota Shimouchi, Susumu Date, Toshie Kai

“…Furthermore, we screened the majority of Drosophila proteins (~12,000) for potential interaction with the Piwi protein, a central player in the piRNA pathway, identifying 164 pairs as potential binding partners. This in silico approach not only efficiently identifies potential interaction partners but also significantly bridges the gap by facilitating the integration of bioinformatics and experimental biology.…”
Get full text

Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Conclusion: Our multi-omics integration identifies JUN and HLA-A as central coordinators of alternative splicing programs in SLE T cells. …”
Get full text

The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity. by Kaori Oikawa, Koki Fujisaki, Motoki Shimizu, Takumi Takeda, Keiichiro Nemoto, Hiromasa Saitoh, Akiko Hirabuchi, Yukie Hiraka, Naomi Miyaji, Aleksandra Białas, Thorsten Langner, Ronny Kellner, Tolga O Bozkurt, Stella Cesari, Thomas Kroj, Mark J Banfield, Sophien Kamoun, Ryohei Terauchi

“…Yet this binding carries a trade-off, it triggers immunity in plants carrying NLR receptors with integrated HMA domains.…”
Get full text

Identification of potential geosmin-binding proteins in grass carp gill based on affinity responsive target stability and tandem mass tag proteomics by Jun-ming Zhang, Huan Han, Bing Fu, Yi-chao Li, Kang Li, Jing-wei Liu, Er-meng Yu, Li-ping Liu

“…Its impact extends to aquatic organisms, with current research focusing on dose-response and ecotoxicity, while neglecting the molecular-level study of geosmin-binding proteins. This study employs an integrated approach combing affinity-responsive target stability in vitro, tandem mass tag proteomics in vivo, and molecular docking to identify geosmin-binding proteins in the gill tissue of grass carp (Ctenopharyngodon idella). …”
Get full text

I am Once Again Asking for Your Attention: A Replication of Feature-Based Attention Modulations of Binding Effects with Picture Stimuli by Tarini Singh, Lars-Michael Schöpper, Christian Frings

“…Action control theories assume that stimulus and response features are integrated or bound into short term episodic traces. …”
Get full text

A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex by Thomas Gaber, Thomas Monecke, Julia Grabowski, Bernd Simon, Tobias Williams, Vera Roman, Jeffrey Chao, Janosch Hennig, Anne Ephrussi, Dierk Niessing, Simone Heber

“…Staufen, a double-stranded RNA (dsRNA)-binding protein, has been shown to bind the oskar mRNA transport complex in the oocyte and inactivate dynein; however, it remains unclear how kinesin is activated. …”
Get full text

Characterization of dsRNA binding proteins through solubility analysis identifies ZNF385A as a dsRNA homeostasis regulator by Na Jiang, Hekun Yang, Yi Lei, Weida Qin, Huifang Xiong, Kuan Chen, Kunrong Mei, Gongyu Li, Xin Mu, Ruibing Chen

“…Abstract Double-stranded RNA (dsRNA) binding proteins (dsRBPs) play crucial roles in various cellular processes, especially in the innate immune response. …”
Get full text

Genome-Wide Association Study of Brown Rice Weight Identifies an RNA-Binding Protein Antagonistically Regulating Grain Weight and Panicle Number by Lin Zhou, Hong Jiang, Long Huang, Ziang Li, Zhonghao Yao, Linhan Li, Kangwei Ji, Yijie Li, Haijuan Tang, Jinping Cheng, Yongmei Bao, Ji Huang, Hongsheng Zhang, Sunlu Chen

“…Intriguingly, through integrated analysis of mutant phenotypes and haplotype variations, we demonstrated that BRW1.1 mediates the physiological tradeoff between GW and panicle number. …”
Get full text