Exploration of the Mechanisms of <i>Acorus</i><i> tatarinowii</i> in the Treatment of Major Depressive Disorder Based on Network Pharmacology and Molecular Docking Techniques by Li Han, Siwen Wei, Rong Wang, Yiran Liu, Yi Zhong, Huaiqing Luo

“…Molecular docking studies demonstrated strong binding affinities between key compounds and their respective targets. …”
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Genomic and Multi-Omics Analysis of <i>Phlebopus portentosus</i>: Effects of Cultivation on Secondary Metabolites by Zujiang Kang, Xiaolong Yuan, Chuanguang Zhang, Yi Wang, Lu Li, Yuan Zheng

“…In this study, the genomics, metabolomics, and transcriptomics were integrated to reveal the biosynthesis mechanism of secondary metabolites in <i>P. portentosus</i> under different cultivation conditions. …”
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Thiazolo-pyridopyrimidines: An in silico evaluation as a lead for CDK4/6 inhibition, synthesis and cytotoxicity screening against breast cancer cell lines by Chaithra R Shetty, C. S. Shastry, Parasuraman P, Srinivas Hebbar

“…To further evaluate stability, molecular dynamics simulations were conducted for the two most promising compounds within the binding site. Results: The docking scores indicated stronger interactions for compounds 4a, 4c, 4d, and 4g. …”
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Mechanistic insights into the effects of Tris-2-butoxyethyl phosphate on multiple cancers using network toxicology and molecular docking by Hongting Lu, Pengyu Huang, Bingqi Huang, Dongming He, Xinhuai Ou, Zhanyu Xu, Shikang Li

“…Fourteen representative cancer types were selected to explore the molecular pathways through which TBEP may exert its effects. By integrating network toxicology, molecular docking, and molecular dynamics (MD) simulations, we elucidated the underlying mechanisms of TBEP-related carcinogenicity. …”
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Exploring the key ingredients and mechanisms of Banxia Xiexin decoction for the treatment of polycystic ovary syndrome based on network pharmacology and experimental validation by Bai Hai, Yingying Zhang, Jing Huang, Richard Mprah, Mingming Wang

“…Purpose This study aimed to investigate the key bioactive constituents and polypharmacological mechanisms of Banxia Xiexin Decoction (BXD) against polycystic ovary syndrome (PCOS) through integrated network pharmacology and experimental validation.Methods Network pharmacology was used to determine the key ingredients, potential targets and signaling pathways. 3-week-old female mice were injected subcutaneously with DHEA (6mg/100g body weight) daily to construct a PCOS model and administered different doses BXD and its key ingredients for intervention. …”
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Real‐Time PCR Assay and Environmental DNA Workflow for Detecting Irukandji Jellyfish, Malo bella (Cubozoa) by Jessica K. Strickland, Kylie A. Pitt, Michael J. Kingsford, Scott J. Morrissey, Dean R. Jerry

“…Future research should explore integrating passive or automated samplers and developing real‐time detection assays to further enhance monitoring capabilities and mitigate risks posed by hazardous marine species.…”
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Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer by Teng Wang, Zhaoming Chen, Wang Wang, Wang Wang, Heng Wang, Shenglong Li

“…A prognostic model was then established through Lasso and Cox regression analyses, integrating clinical data into a nomogram for personalized risk prediction. …”
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Temperature-driven metabolic shifts in duck egg components during early embryogenesis: from diapause to active developmental phase by Zekuan Zuo, Qian Chen, Chengxin Hu, Qian Tang, Chenling Song, Hehe Liu

“…Differential metabolite analysis in yolk and albumen was integrated with KEGG pathway enrichment to identify functional shifts linked to embryonic reactivation. …”
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Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes by Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai, Xin Xiao, Ben Wang, Zhili Deng, Ji Li

“…Among these, keratin 6A (KRT6A) plays a role in maintaining skin barrier integrity. Methods We treated mouse skin and human keratinocytes, with and without KRT6A expression, with LL37/TNF-α and assessed the severity of inflammation. …”
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Near-collector electroprinting of cellulose acetate structures with large specific surface per volume by Farnaz Rezaei, Daniel O. Carlsson, Jimmy Hedin Dahlstrom, Jonas Lindh, Stefan Johansson

“…Results showed that 3D-printed structures with a 5 μm pitch achieved a Sv similar to electrospun filters.Incorporating polyethyleneimine (PEI) in the CA ink enabled the 3D-printed structures to gain ion binding capacity which was further investigated. This ion-exchange ability which integrated into the printing step, eliminating the need for a separate post-modification process in bio-separation applications. …”
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NAVIGATING FINTECH SHARIA REGULATION IN INDONESIA: LESSONS LEARNED FROM MALAYSIA by Ermanto Fahamsyah, Kania Venisa Rachim, Ramadhan Dwi Saputra, Vicko Taniady

“…These research questions are crucial, as they delve into fundamental areas that define the operational integrity and user trust in Sharia-compliant financial technologies. …”
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Elucidating the mechanism of plasticizers inducing breast cancer through network toxicology and molecular docking analysis by Na He, Jing Zhang, Mingyu Liu, Li Yin

“…Results: Enrichment analysis highlighted the association of these plasticizer-targeted genes with pathways integral to adenocarcinoma development, suggesting a broad impact of plasticizers on hormone-dependent and other forms of cancers. …”
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Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study by Zhengjie Zhu, Yujian Zhong, Ruyuan He, Changheng Zhong, Junwen Chen, Hao Peng

“…Molecular docking and dynamics simulations confirmed stable binding of salvigenin to <i>ESR1</i>. Salvigenin significantly reduced Dex-induced oxidative stress and apoptosis in osteoblasts while restoring osteogenic differentiation and <i>ESR1</i> expression. …”
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C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation by Yongfeng Hu, Shaoqiang Li, Yunhui Hong, Dongxian Peng

“…Molecular docking confirmed BPA and PFOS binding to C3AR1. Reduced C3AR1 in preeclamptic placentas correlated with maternal blood pressure, and showed high diagnostic potential (AUC = 0.95). …”
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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis by Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri

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Dual-loaded niosome-dendrimer nanoplatform enhances Tirapazamine delivery to hypoxic breast cancer cells by Masoumeh Kaveh Zenjanab, Aysan Salemi, Abolfazl Doustmihan, Sajjad Alimohammadvand, Rana Jahanban Esfahlan

“…Molecular docking and protein–protein interaction network analysis identified HIF1A as a central target for Tirapazamine (TPZ), revealing multiple high-confidence binding sites and interactions with key cancer-related pathways. …”
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Internet Debates: Generations X, Y and Z by G. B. Elagin, I. B. Mikirtumov

“…The theory of generations by Neil Howe and William Strauss has become an integral part of “folk sociology” today, so that everyone somehow asks the question of which generational group he / she belongs to and what behavior is expected of him / her, in particular, in network communications. …”
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MAST Kinases’ Function and Regulation: Insights from Structural Modeling and Disease Mutations by Michael C. Lemke, Nithin R. Avala, Michael T. Rader, Stefan R. Hargett, Daniel S. Lank, Brandon D. Seltzer, Thurl E. Harris

“…We also estimate the functional consequences of disease point mutations on protein stability by integrating predictive algorithms and AlphaFold. <b>Results</b>: Higher-order organisms often have multiple MASTs and a single MASTL kinase. …”
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Molecular mechanisms of acquired idiopathic generalized anhidrosis: differential gene expression and potential therapeutic targets by Sanjukta Dasgupta

“…Molecular docking confirmed a strong binding affinity between ciprofibrate and JUN, suggesting ciprofibrate could modulate JUN activity and regulate AIGA symptoms. …”
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Using fluorescently labeled wheat germ agglutinin to track lipopolysaccharide transport to the outer membrane in Escherichia coli by Laurent Dubois, Andrea Vettiger, Jackson A. Buss, Thomas G. Bernhardt

“…The outer membrane (OM) contains integrated beta-barrel proteins and has an outer leaflet composed of lipopolysaccharide (LPS). …”
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