Correlation between calculated electronic properties and antibacterial activity of chiral amino acid schiff base copper(II) complexes by Mao Narita, Yuma Yamamoto, Daisuke Nakane, Takashiro Akitsu, Brice Rostan Pinlap, Boniface Pone Kamdem, Fabrice Fekam Boyom

“…These results highlight the importance of combining global electronic descriptors with local binding interactions in evaluating biological activity. …”
Get full text

Cpx-signalling in Yersinia pseudotuberculosis modulates Lipid-A remodelling and resistance to last-resort antimicrobials by Dharmender K. Gahlot, Jonasz B. Patkowski, Jaime Fernández de Santaella, Luke P. Allsopp, Zhiqiao Pan, Alain Filloux, Gerald Larrouy-Maumus, Matthew S. Francis, Tiago R. D. Costa

“…In vivo transcriptional analysis and in vitro protein-DNA binding studies demonstrated that these modifications were dependent on the direct regulation of Lipid-A biogenesis and modifications of operons by the active phosphorylated CpxR~P isoform. …”
Get full text

Characterization of the growth-related transcriptome in the Liver and Brain of mandarin fish (Siniperca chuatsi) through RNA-Seq analysis by Weidong Ding, Liping Cao, Zheming Cao, Xuwen Bing

“…These DEGs were associated with signaling pathways involved in growth and development, such as AGE-RAGE, Transforming growth factor-β/Smad, Mitogen-activated protein kinase, Wingless/Integrated, and Insulin-like growth factor (IGF) 1. …”
Get full text

The downregulation of hormone-sensitive lipase and dysregulation of cholesterol receptors/transporter affect testicular lipid homeostasis and function in HFD-induced oligoasthenosp... by Min Pan, Jingya Li, Yujia Wang, Ziao Liu, Li Li, Tongsheng Wang

“…Testosterone synthesis and Blood-testis barrier (BTB) integrity were evaluated by ELISA, Transmission electron microscope, and WB. …”
Get full text

To reveal the key mechanism of Citri Reticulatae Pericarpium–Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect... by Chen Lin, Yujie Wang, Xiao Lin, Chufan Ren, Yifeng Wang, Yizhong Ma, Jiahao Zhou, Chuyu Gu, Jianyi Wang

Get full text

Interlayer excitons diffusion and transport in van der Waals heterostructures by Yingying Chen, Qiubao Lin, Haizhen Wang, Dehui Li

“…The rich exciton landscapes in TMD heterostructures, combined with advancements in valleytronics and twistronics, hold great promise for exploring exciton-integrated circuits base on manipulation of exciton diffusion and transport. …”
Get full text

Dysregulated lipid metabolism in kidney stone pathogenesis: a literature review of mechanistic insights and therapeutic implications by Quan Wen, Qiuyu Li, Haoji Zhou, Boyan Su, Yalin Ren, Qiqi He

“…This review systematically integrates epidemiological, animal model, and molecular mechanism studies to explore the mechanisms by which lipid metabolism disorders promote KSD through key regulatory factors, such as peroxisome proliferator-activated receptors (PPARs), fatty acid-binding proteins (FABPs), and apolipoproteins, synergizing with organelle damage pathways, including mitochondrial dysfunction, endoplasmic reticulum stress (ERS), and ferroptosis. …”
Get full text

Nonlinear mixed-effects models to analyze actin dynamics in dendritic spines by Gioia Di Credico, Silvia Pelucchi, Francesco Pauli, Ramona Stringhi, Elena Marcello, Valeria Edefonti

“…We propose a nonlinear mixed-effects model to integrate the one-phase association model estimate with the nested data structure of FRAP experiments; this also allows us to model heteroscedasticity and time dependence in the data. …”
Get full text

Expanding the chitin oligosaccharide portfolio by engineering NodC chitin synthases in Escherichia coli by Chiara Guidi, Xevi Biarnés, Antoni Planas, Marjan De Mey

“…Charge density at the transmembrane helices of NodC affects the opening of the integral binding pocket and in this way the length of the produced chitin oligomers can be modulated. …”
Get full text

Design and synthesis of 3,4-seco-lupane triterpene-tryptamine derivatives and revealing their anti-bladder cancer mechanisms by combining TCGA and transcriptomic approaches by Qinglong Chi, Hongbo Teng, Yaru Zhao, Xv Wang, Jiexin Zhang, Huiyue Shen, Xuan He, Yan Zhao, Chunxi Wang

“…Molecular docking confirmed the stable binding of compound 27 to DUSP5, which was confirmed by molecular dynamics simulations. …”
Get full text

FOS as a biomarker for myocardial infarction treatment with Deng's Yangxin Decoction: a systems biology-based analysis by Junfeng Fang, Wei Wu, Weifeng He, Lin Wang, Shiyi Liu

“…Molecular docking confirmed strong binding affinities between quercetin/baicalein and FOS. …”
Get full text

Grape Pomace Seed and Skin Powder as a Source of Dietary Fibre by Danijel Milinčić, Bojana Vidović, Slađana Stanojević, Mirjana Pešić

“…They can be used as gelling or binding water agents. However, they are mostly incorporated into various food products as an integral part of milled pomace flour and powder, contributing to their functional, nutritional, physicochemical, textural, and sensory properties. …”
Get full text

The Position of Choice of Forum and Alternative Dispute Resolution Principles in Contemporary Sharia-Based Property Dispute by Abdul Hakim Pratama, Hasbir Paserangi, Adi Nurhani Mufrih, Abdul Halim Talli, Mohd Al Adib bin Samuri

“…Using a qualitative method with statutory, comparative, and case study approaches, the research reveals that forum choice clauses in sharia contracts are legally valid and binding, as supported by Supreme Court Circular Letter (SEMA) No. 4 of 2016. …”
Get full text

Subcellular spatial regulation of immunity-induced phosphorylation of RIN4 links PAMP-triggered immunity to Exo70B1 by Yi Zhao, Brad Day, Brad Day, Brad Day, Brad Day

“…We found that RIN4’s PM tethering relies on Exo70B1-mediated exocytosis and the integrity of the host cytoskeletal actin network. Phosphorylation at RIN4T166 disrupts its PM localization due to reduced binding affinity with Exo70B1. …”
Get full text

Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation by Jiaxin Chu, Jianqiang Song, Zhuolin Fan, Ruijun Zhang, Qiwei Wang, Kexin Yi, Quan Gong, Benju Liu

“…Molecular docking confirmed a strong binding affinity between 3-MA and AKT/GSK3β. In animal experiments, 3-MA significantly reduced blood glucose levels in diabetic mice, ameliorated learning and memory deficits, and preserved hippocampal neuronal integrity. …”
Get full text

The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma by Busra Aydin, Keziban Okutan, Ozge Onluturk Aydogan, Raghu Sinha, Beste Turanli

“…The drug repositioning analysis revealed vorinostat, meclocycline sulfosalicylate, and trichostatin A, which exhibited significant binding affinities to the hub genes compared to their inhibitors via molecular docking analysis.…”
Get full text

In vitro and in silico insights into antimicrobial and anticancer activities of novel imidazo[2,1-b][1,3,4]thiadiazoles by Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey, K Sreedhara Ranganath Pai, Santosh L. Gaonkar

“…Molecular docking was studied to determine the docking poses and binding interaction of the derivatives with the protein bearing PDB: 5BNS and 3ZNR; ADME properties of the derivatives are also inferred which gives insights into the bioavailability. …”
Get full text

Serum Proteomic Changes in Pet Rabbits with Subclinical and Clinical Encephalitozoonosis in Thailand by Taksaon Duangurai, Onrapak Reamtong, Tipparat Thiangtrongjit, Siriluk Jala, Peerut Chienwichai, Naris Thengchaisri

“…These include markers related to the immune response (beta-2-microglobulin, alpha-2-HS-glycoprotein), coagulation (antithrombin-III, alpha-1-antiproteinase S-1), vitamin A transport (retinol-binding proteins), lipid metabolism (apolipoprotein C-III), cytoskeletal regulation (actin-depolymerizing factor), extracellular matrix integrity (fibrillin 2), and oxidative stress (monooxygenase DBH-like 1). …”
Get full text

Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function by Jeffrey D. Rothstein, Olivia Keeley, Caroline Warlick, Timothy M. Miller, Cindy V. Ly, Jonathan D. Glass, Alyssa N. Coyne

“…Abstract Nuclear loss and cytoplasmic buildup of the RNA-binding protein TDP-43 is a hallmark of ALS and related disorders. …”
Get full text

The Potential Mechanism of Cuproptosis in Hemocytes of the Pacific Oyster <i>Crassostrea gigas</i> upon Elesclomol Treatment by Yuxin Zhang, Jiejie Sun, Shurong Li, Lingling Wang, Linsheng Song

“…<i>Cg</i>DLAT is composed of a biotin_lipoyl domain, an E3-binding domain, and a 2-oxoacid_dh domain. <i>CgFDX1</i> and <i>CgDLAT</i> mRNA were expressed in all the examined tissues. …”
Get full text