Generalization of neoantigen-based tumor vaccine by delivering peptide-MHC complex via oncolytic virus by Chenyi Wang, Yingjun Shi, Da Zhang, Yupeng Sun, Junjie Xie, Bingchen Wu, Cuilin Zhang, Xiaolong Liu

“…To overcome these limitations, we engineered oncolytic viruses co-expressing neoantigens and neoantigen-binding major histocompatibility complex (MHC) molecules to force ectopic delivery of peptide-MHC ligands to T cell receptors (TCRs), enabling specific targeting by neoantigen vaccine-primed host immunity. …”
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Network toxicological and molecular docking in investigating the mechanisms of toxicity of agricultural chemical pyraclostrobin by Shen-sui Li, Xu-dong Tian, Ju-kun Song, Ya-dong Wu, Wei-li Wang, Zheng-long Tang, Jin-bo Wang

“…Molecular docking confirmed PYR's binding affinity to these targets, indicating its potential role in disease pathogenesis. …”
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The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice by Yu Yang, Yu Chen, Jie Chen, Danyu Zhang, Jianhua Wang, Xiaodong Mao, Xiao Wei, Xingjia Li, Xianghua Ma, Chao Liu, Kun Wang

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Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis by Peishan Qiu, Ying Chang, Xiaoyu Chen, Shaoqi Wang, Haihang Nie, Yuntian Hong, Meng Zhang, Haizhou Wang, Cong Xiao, Yuhua Chen, Lan Liu, Qiu Zhao

“…A strong correlation existed between the elevation of glial fibrillary acidic protein (GFAP)+/S100 calcium binding protein B (S100β)+ enteric glial cells (EGCs) in inflamed colonic tissues and the disruption of the intestinal epithelial barrier (IEB) and gut vascular barrier (GVB) observed in chronic colitis. …”
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Molecular basis for the regulation of human phosphorylase kinase by phosphorylation and Ca2+ by Ruifang Ma, Bowen Du, Chen Shi, Lei Wang, Fuxing Zeng, Jie Han, Huiyi Guan, Yong Wang, Kaige Yan

“…Abstract Phosphorylase kinase (PhK) regulates the degradation of glycogen by integrating diverse signals, providing energy to the organism. …”
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Unveiling the therapeutic role of penfluridol and BMS-754,807: NUDT5 inhibition in breast cancer by Majed S. AlFayi, Mohd Saeed, Irfan Ahmad, Mohd Adnan Kausar, Samra Siddiqui, Saba Irem, Faisal Fawaz Alshammari, Riadh Badraoui, Dharmendra Kumar Yadav

“…Nudix hydrolase 5 (NUDT5), an enzyme integral to ADP-ribose metabolism, DNA repair, and hormone-driven transcription, has emerged as a promising therapeutic target. …”
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Extracorporeal therapies in sepsis: a comprehensive review of the Selective Cytopheretic Device, Polymyxin B and Seraph cartridges by Lucas Yessayan, Chris J. Pino, H. David Humes

“…Further research is needed to establish optimal protocols for their initiation, duration, and integration into standard sepsis management.…”
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Enhanced osteogenic potential of spider silk fibroin-based composite scaffolds incorporating carboxymethyl cellulose for bone tissue engineering by Woong Jin Lee, Kyoungjoo Cho, Dayoon Lee, Seungmin Lee, Hyojae Jeon, Aaron Youngjae Kim, Gyung Whan Kim

“…Fibroin, obtained from spider silk, serves as a valuable biomaterial and constitutes the primary component of fibrous protein-based spider silk threads. To enhance the binding efficiency in bone formation after scaffold implantation, CMC was integrated into fibroin, aiming to improve the injectability properties of the scaffold in bone substitutes. …”
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Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin by Seok Gi Kim, Jinyan Li, Ji Su Hwang, Muhammad Anwar Ul Hassan, Ye Eun Sim, Ju Yeon Lee, Jung-Soon Mo, Myeong Ok Kim, Gwang Lee, Sungsu Park

“…Zyxin emerges as a novel synphilin-1 binding protein, and synphilin-1 overexpression reduces the nuclear translocation of yes-associated protein. …”
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Engineering of photo-inducible binary interaction tools for biomedical applications by Yi-Tsang Lee, Lei Guo, Tien-Hung Lan, Tatsuki Nonomura, Gan Liu, Guolin Ma, Rui Wang, Yun Huang, Yubin Zhou

“…Abstract The ssrA-sspB dimerization system, derived from the bacterial degradation machinery, comprises a 7-residue ssrA peptide and its binding partner sspB. The compact size of ssrA makes it ideal for insertion into proteins of interest to manipulate host protein function by engineered light-responsive sspB. …”
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Immune signature and pathways investigation of adrenal gland diffuse large B-cell lymphoma by Weijing Jia, Ruochen Qi, Xiaoyan Zhang, Kepu Liu, Longlong Zhang, Xiaozheng Fan, Bo Yang, Guohui Wang, Shichao Han, Shuaijun Ma

“…We performed RNA sequencing of ten DLBCL samples from adrenal gland, integrated analyzed DLBCL RNA data from multiple organs, defined the new subtypes of adrenal gland DLBCL and explored their molecular signatures. …”
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Atomic-level Ru-Ir mixing in rutile-type (RuIr)O2 for efficient and durable oxygen evolution catalysis by Yeji Park, Ho Yeon Jang, Tae Kyung Lee, Taekyung Kim, Doyeop Kim, Dongjin Kim, Hionsuck Baik, Jinwon Choi, Taehyun Kwon, Sung Jong Yoo, Seoin Back, Kwangyeol Lee

“…In situ spectroscopic analysis and computational calculations highlight the importance of the synergistic coexistence of Ru/Ir-dual-OER-active sites for mitigating Ru dissolution via the optimization of the binding energy with oxygen intermediates and stabilization of Ru sites.…”
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Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies by Doaa Samaha, Sawsan Mahmoud, Mosaad Sayed Mohamed, Rokaia S. Abdullah, Nageh A. Abou Taleb, Tomohisa Nagamatsu, Hamed I. Ali

“…Correlation analyses demonstrated a strong relationship between the IC50 values and AutoDock binding free energy or calculated inhibition (Ki). …”
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Rbm3 deficiency leads to transcriptome-wide splicing alterations by Steffen Erkelenz, Marta Grzonka, Antonios Papadakis, Heiner Schaal, Jan H. J. Hoeijmakers, Ákos Gyenis

“…Rbm3 (RNA-binding motif protein 3) is a stress responsive gene, which maintains cellular homeostasis and promotes survival upon various harmful cellular stimuli. …”
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Incorporating graph representation and mutual attention mechanism for MiRNA-MRNA interaction prediction by Tai-Long Shi, Lei Wang, Lei Wang, Leon Wong, Zhu-Hong You, Chang-Qing Yu, Chen Jiang, Si-Zhe Liang

“…The method introduces antisense-aware sequence processing that reverses mRNA orientation to better simulate the natural miRNA-mRNA complementary binding mechanism. Additionally, GRMMI employs cross-sequence mutual attention architecture that enables deep exploration of inter-RNA dependencies beyond traditional single-sequence analysis limitations. …”
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PET Foils Functionalized with Reactive Copolymers as Adaptable Microvolume ELISA Spot Array Platforms for Multiplex Serological Analysis of SARS-CoV-2 Infections by Sylwia Pniewska, Marcin Drozd, Alessandro Mussida, Dario Brambilla, Marcella Chiari, Waldemar Rastawicki, Elżbieta Malinowska

“…These findings underscore the potential of PET-based microvolume ELISA arrays as scalable, high-throughput diagnostic tools suitable for detecting multiple biomarkers in a single assay and easily integrated into microfluidic devices.…”
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Tracking the genome-wide occupancy of Arabidopsis LEAFY COTYLEDON1 in endosperm development by Jingpu Song, Xin Xie, Ioannis Mavraganis, Bianyun Yu, Wenyun Shen, Hui Yang, Daoquan Xiang, Yangdou Wei, Yuhai Cui, Jitao Zou

“…To address this, we employed a modified INTACT system to isolate endosperm nuclei and performed ChIP-seq to map the genome-wide binding profile of LEC1 in developing endosperm. Integrating ChIP-seq with transcriptomic analyses, we uncover a critical role for LEC1 in regulating diverse biological pathways. …”
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Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway by Hanefi Ozbek, Ibrahim Yilmaz, Aslı Akyuz, Suray Pehlivanoglu, Duygu Yasar Sirin, Mehmet Albayrak, Omer Faruk Yilmaz

“…Abstract Background This study aimed to investigate the effects of Lopinavir/Ritonavir (Lop/r) on chondrocyte structure and extracellular matrix (ECM) integrity, as well as its impact on key proteins involved in anabolic and catabolic pathways, using both in vitro and in silico approaches. …”
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Innovative Peptide-Based Plasmonic Optical Biosensor for the Determination of Cholesterol by Ana Lia Bernardo, Anne Parra, Virginia Cebrián, Óscar Ahumada, Sergio Oddi, Enrico Dainese

“…In the present study, a novel strategy for cholesterol quantification was developed, leveraging a plasmonic optical readout in conjunction with a highly specific cholesterol-binding peptide (C-pept) as a biorecognition element, anchored on a functionalized silica substrate. …”
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Combined Antiviral and Cytoprotective Action of Rosmarinic Acid Against EV-A71 Infection: A Potential Therapeutic Strategy by Junping Lv, Weishi Lin, Siqi Chao, Jing Xie, Yue Cao, Jinfeng Tie, Yuehua Ke, Binan Lu, Zongran Pang

“…Molecular docking indicated strong binding of RA to the hydrophobic pocket of VP1, potentially disrupting virus-host interactions. …”
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