Specific functions of BIG1 and BIG2 in endomembrane organization. by Frédéric Boal, David J Stephens

“…BIG1 is required to maintain the normal morphology of the Golgi; BIG2 is important for endosomal compartment integrity and cannot replace the function of BIG1 in Golgi organization.…”
Get full text

Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections by Gielenny M. Salem, Fan-Chi Chen, James J. Cai, Day-Yu Chao, Day-Yu Chao, Day-Yu Chao

Get full text

Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay. by Ido Lavi, Supriya Bhattacharya, Ankita Awase, Ola Orgil, Nir Avital, Guy Journo, Vyacheslav Gurevich, Meir Shamay

“…During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure episome maintenance, the latency protein LANA tethers the viral episomes to the cell chromosomes during cell division. …”
Get full text

DISSENTING OPINION OF JUDGES IN THE PERSPECTIVE OF SIYASAH SYAR’IYYAH: A Study of the Constitutional Court Decisions No. 1/PHPU.PRES-XXI/2024 and No. 2/PHPU.PRES-XII/2024 (the Pres... by Wilda Mawarni, Kelik Wardiono

“…In Indonesia, dissenting opinions, though non-binding, play an essential role in the judicial process by offering alternative interpretations and critiques of the majority's rulings. …”
Get full text

Forecast of the Dynamics of the Number of Russian Banks Until 2025 by D. S. Rukavishnikov

“…Effective functioning of the banking system is a prerequisite for the development of market relations in Russia, which objectively determines the key role of the Central Bank in regulating banking activities. Banks form an integral part of the modern money economy. Their activities are closely related to the needs of production. …”
Get full text

Transcriptomic Analysis on Developing Seed Uncovers Candidate Genes Associated with Seed Storage Protein in Soybean by Li Hu, Huibin Huang, Wenjun Li, Runqing Duan, Dongyan Li, Xianzhi Wang

“…Seven candidate genes exhibiting two different gene regulation patterns were identified, six of which are directly related to the seed storage protein pathway, and one of which is related to the carbon binding pathway. An integrated analysis of transcriptomic and candidate gene expression trend suggested that 40 days after flowering (DAF) might be a crucial period for seed protein accumulation in soybean. …”
Get full text

Recent advances in the treatment of non-small cell lung cancer with MET inhibitors by Dongna Zhang, Wenying Zhang, He Liu, Pan Liu, Chunxin Li, Yangyang Liu, Jicheng Han, Guangze Zhu

Get full text

Cycloadditions as a Sweet Route to ‘Double <i>C</i>-Glycosylation’ by Kevin P. P. Mahoney, Rosemary Lynch, Rhea T. Bown, Sunil V. Sharma, Piyasiri Chueakwon, G. Richard Stephenson, David B. Cordes, Alexandra M. Z. Slawin, Rebecca J. M. Goss

Get full text

Discovery of selective ACAT2 antagonist via a combination strategy based on deep docking, pharmacophore modelling, and molecular dynamics simulation by Yanfeng Liu, Feng Ding, Liangying Deng, Shuran Zhang, Lixing Wu, Huangjin Tong

Get full text

A short-chain dehydrogenase/reductase gene confers resistance to Verticillium wilt in cotton and reveals adaptive selection during domestication by Mubashir Abbas, Muhammad Jawad Umer, Aamir Ali Abro, Zhang Menghan, Chao Lu, Qiankun Liu, Heng Wang, Mengying Yang, Yiman Liu, Huang Wenjuan, Muhammad Aamir Khan, Muhammad Ali Abid, Muhammad Askari, Muhammad Aneeq Ur Rahman, Yuqing Hou, Jie Zhang, Yanchao Xu, Xiaoyan Cai, Zhongli Zhou, Rui Zhang, Fang Liu

Get full text

S-palmitoylation of MAP kinase is essential for fungal virulence by Yuhang Duan, Pingping Li, Deyao Zhang, Lili Wang, Yuan Fang, Hong Hu, Qiulu Mao, Xiaolan Zhou, Panpan Zhao, Xuechun Li, Jinfeng Wei, Jintian Tang, Li Pan, Hao Liu, Xiaolin Chen, Xiaoyang Chen, Tom Hsiang, Junbin Huang, Lu Zheng

Get full text

Novel ¹⁷⁷Lu-Labeled [Thz¹⁴]Bombesin(6–14) Derivatives with Low Pancreas Accumulation for Targeting Gastrin-Releasing Peptide Receptor-Expressing Cancer by Lei Wang, Devon E. Chapple, Hsiou-Ting Kuo, Sara Kurkowska, Ryan P. Wilson, Wing Sum Lau, Pauline Ng, Carlos Uribe, François Bénard, Kuo-Shyan Lin

Get full text

Unveiling the mechanisms and promising molecular targets of curcumin in pancreatic cancer through multi-dimensional data by HongMing Xie, JieBin Liang, HongBiao He, Zewei Zhuo, JiaXuan Li

Get full text

Antisense oligonucleotides targeting IRF4 alleviate psoriasis by Yanxia Yu, Yirui Wang, Weiwei Chen, Chang Zhang, Zhuo li, Jing Yu, Minhao Wang, Can Song, Sihao Yan, Jiayi Lu, Liangdan Sun

Get full text

Recent Advances in the Development of Functional Nucleic Acid Biosensors Based on Aptamer-Rolling Circle Amplification by Ce Liu, Wanchong He

“…Due to their ability to bind precisely to these targets, aptamers have found widespread use in bioanalytical and diagnostic applications. …”
Get full text

A generic cell surface ligand system for studying cell-cell recognition. by Eleanor M Denham, Michael I Barton, Susannah M Black, Marcus J Bridge, Ben de Wet, Rachel L Paterson, P Anton van der Merwe, Jesse Goyette

“…Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating the surface density of ligands at a cell-cell interface. …”
Get full text

Molecular insights into pangenome localization and constructs design for Hemophilus influenza vaccine by Naila Zaman, Kainat Gul, Kinza Khurram, Syed Sikander Azam

“…To further stabilize the vaccine construct, we performed disulfide engineering to enhance structural integrity and resilience. Comprehensive validation through in silico immune simulations, molecular dynamics (MD) simulations and binding free energy calculations confirmed the structural stability, immunogenic potential, and strong receptor affinity of the MEV candidate. …”
Get full text

Identification and Characterisation of Potential Targets for N6-methyladenosine (m6A) Modification during Intervertebral Disc Degeneration by Jianlin Shen, Qiang Zhang, Yujian Lan, Qingping Peng, Ziyu Ji, Yanjiao Wu, Huan Liu

Get full text

Chromatin accessibility and transcriptomic profiles of sheep pituitary function associated with fecundity by Shanglai Li, Bingru Zhao, Peiyong Chen, Yu Cai, Hui Xu, Chenbo Yan, Feng Wang, Yanli Zhang

“…To address this knowledge gap, we performed an integrated multi-omics analysis of ATAC-seq and RNA-seq profiling of pituitary from sheep with divergent fecundity phenotypes. …”
Get full text

Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer by Shenglan He, Jianmei Ji, Kaisi Zhu, Youlan Chen, Xiaowen Xu

“…Integrated bioinformatic analysis elucidated the mechanistic role of SB in CAFs-mediated CRC progression.ResultsIn vivo studies showed that SB effectively reduced POSTN and α-SMA protein levels in CAFs in AOM/DSS-induced CRC mice. …”
Get full text