Sanguinarine identified as a natural dual inhibitor of AURKA and CDK2 through network pharmacology and bioinformatics approaches by Xiang Li, Qi You

“…Molecular docking and molecular simulation dynamics analyses have confirmed the stable binding of both AURKA and CDK2 to SANG. In summary, by integrating diverse methodological approaches, this study discovered that SANG potentially inhibits the malignant features of CA by targeting AURKA and CDK2, thereby regulating DNA replication, cell cycle progression, and multiple DNA repair pathways. …”
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Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. by Sonja C Vernes, Peter L Oliver, Elizabeth Spiteri, Helen E Lockstone, Rathi Puliyadi, Jennifer M Taylor, Joses Ho, Cedric Mombereau, Ariel Brewer, Ernesto Lowy, Jérôme Nicod, Matthias Groszer, Dilair Baban, Natasha Sahgal, Jean-Baptiste Cazier, Jiannis Ragoussis, Kay E Davies, Daniel H Geschwind, Simon E Fisher

“…Specifically, we performed genome-wide in vivo ChIP-chip screens for Foxp2-binding and thereby identified a set of 264 high-confidence neural targets under strict, empirically derived significance thresholds. …”
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Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction by Xiaofen Liu, Malgorzata Krezel, Weiwei Wang

“…It is highly expressed in the spinal dorsal horn where sensory information is integrated. Under inflammatory conditions, the large unstructured intracellular M3/M4 loops of the α3 subunit are phosphorylated through the prostaglandin E2 (PGE2) pathway, inhibiting ion conduction, and resulting in elevated pain sensation. …”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…When these compounds were docked on to Bax, Caspase-3 Caspase-9 and Cox-2, the proteins integral to the mitochondrial apoptotic pathway, using PyRX software, the docking score was in the range from − 4 to -6.9 kcal/mol. …”
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Proteomics Analysis Suggests Mitochondria Disorders and Cell Death Lead to Spaghetti Meat Myopathy by Brian Bowker, Byungwhi Kong, Hong Zhuang, Janghan Choi, Majid Shakeri

“…Spaghetti meat (SM) is a myopathy that affects the structural integrity of pectoralis major muscles in broilers and accounts for decreased meat acceptability and significant economic losses for the industry. …”
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Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with N... by Fan Yang, Kailun Zhang, Xiaohua Dai, Weimin Jiang

“…Consequently, this study utilized a comprehensive method integrating ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS), network pharmacology, and molecular docking to delineate the active ingredients and potential therapeutic mechanisms of YGYSG for treating HN. …”
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Regulation of Myogenesis by MechanomiR-200c/FoxO3 Axis by Junaith S. Mohamed, Aladin M. Boriek

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Comprehensive analysis of bioinformatics and system biology reveals the association between Girdin and hepatocellular carcinoma. by Tengda Huang, Hongying Chen, Hongyuan Pan, Tian Wu, Xiangyi Ren, Liwen Qin, Kefei Yuan, Fang He

“…<h4>Introduction</h4>Hepatocellular carcinoma is one of the leading causes of cancer-related mortality worldwide. The actin-binding protein Girdin is overexpressed in various tumors, promoting tumorigenesis and progression. …”
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To select the optimal immunohistochemical staining method for pigmented melanoma by Juan Lin, Zhijie You, Xin Chen

“…To identify a reliable immunostaining protocol for pigmented melanoma that preserves tissue integrity while enabling clear observation of antigen-antibody binding. …”
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Optical fiber sensor based on Lossy-mode resonance for tamoxifen detection and sensing applications by Fardin Sadeghfar, Roghaieh Parvizi, Moladad Nikbakht

“…Abstract In this study, we report a novel, eco-friendly optical fiber biosensor for tamoxifen (TAM) detection, featuring a single functional layer of cerium dioxide (CeO2) nanoparticles integrated with a molecularly imprinted polymer (MIP). …”
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Cell type differences in human cytomegalovirus transcription and epigenetic regulation with insights into major immediate-early enhancer-promoter control. by Qiaolin Hu, Ming Li, Mrutyunjaya Parida, Benjamin M Spector, Juan F Santana, Arya Zandvakili, David H Price, Jeffery L Meier

“…Additionally, viral genomes have more nucleosomes, potentially restricting LTF access. A TATA-binding protein (TBP)-IE2-nucleosome complex, with more nucleosome than in fibroblasts, occupies the MIE promoter transcription start site, potentially contributing to its epigenetic silencing.…”
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Influence of packaging types on the aging processes of the semi-finished meat products by N. M. Revutskaya, E. V. Mileenkova, K. V. Sivtseva

“…The thematic review is aimed at the integrated analysis of the aging process of various meat types in correlation with the applied method (“dry”, “wet”), and a review of the packaging methods for proteolytic processes responsible for the formation of taste, aroma, color and texture of the finished food product. …”
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Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. by Holly E Anderson, Alexander Kagansky, Josephine Wardle, Juri Rappsilber, Robin C Allshire, Simon K Whitehall

“…<h4>Conclusions/significance</h4>Overall, these results indicate that Hip4 is an integral component of the HIRA complex that is required for transcriptional silencing at multiple loci.…”
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Centromere-size reduction and chromatin state dynamics following intergenomic hybridization in cotton. by Jinlei Han, Guanjing Hu, Yan Dai, Xin Zhang, Jingjing Tian, Jialiang Zhou, Xinqi Xu, Qi Chen, Xiaobing Kou, Lei Xu, Xinyu Wu, Ziying Sun, Jiahui Geng, Lin Li, Chenyu Qiu, Teame Gereziher Mehari, Baohua Wang, Hui Zhang, Xinlian Shen, Zhenzhen Xu, Jonathan F Wendel, Kai Wang

“…Here, we investigate centromeres of the diploid species Gossypium anomalum (Ga, B-genome) that were transferred into tetraploid cotton G. hirsutum (Gh, AD-genome) as either an additional or integrated chromosome, as well as in synthetic allohexaploid (AABBDD) lines. …”
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The effect of certain N-tritylated phenylalanine conjugates of amino-adenosine-3',5'-cyclic monophosphate on Moloney murine leukaemia virus reverse transcriptase activity by Johann van Zyl, Mario Ariatti, Arthur Hawtrey

“…The latter is then integrated into the host chromosome during viral infection. …”
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Bacterial peptidoglycan levels have brain area, time of day, and sleep loss-induced fluctuations by Erika L. English, James M. Krueger

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Study of Living Hadith; the Phenomenon of Different Religious Inheritance through Wasiat Wajibah by Muhammad Zainuddin Sunarto, Umi Sumbulah

“…This necessary will is intended to preserve the integrity of the family and accommodate the multicultural, multiethnic, and multireligious nature of Indonesian society. …”
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Discuss on scientific construction of ecological risk assessment methods in the high background areas of soil heavy metals by ZHANG Fugui, CHENG Xiaomeng, MA Honghong, SUN Binbin, PENG Min

“…Speciation analysis indicated that heavy metals (As, Cu, Hg, Ni, Pb, and Zn) mainly existed in the forms of strong organic binding state and residual state, with low bioavailability, and the bioavailability of Cd was high. …”
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Characterization of a second class Ie ribonucleotide reductase by Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom

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DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration. by Joji Iida, Rebecca Clancy, Jesse Dorchak, Richard I Somiari, Stella Somiari, Mary Lou Cutler, Richard J Mural, Craig D Shriver

“…CD44 adhesion molecules are expressed in many breast cancer cells and have been demonstrated to play a key role in regulating malignant phenotypes such as growth, migration, and invasion. CD44 is an integral transmembrane protein encoded by a single 20-exon gene. …”
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