The Masc–PSI complex directly induces male-type doublesex splicing in silkworms by Tatsunori Kaneda, Noriko Matsuda-Imai, Hidetaka Kosako, Keisuke Shoji, Masataka G. Suzuki, Yutaka Suzuki, Takashi Kiuchi, Susumu Katsuma

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Evaluation of phytotoxicity and genotoxicity of TMA-stabilized iron-oxide nanoparticle in corn (Zea mays) young plants by Mihaela Răcuciu, Lucian Barbu-Tudoran, Simona Oancea

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Brain Neurotrophins and Plant Polyphenols: A Powerful Connection by Marco Fiore, Sergio Terracina, Giampiero Ferraguti

“…Together, these effects contribute to potentiated enhanced synaptic function, neuronal integrity, and better learning and memory processes. …”
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Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα−positive breast cancer by Taniya Saha, Kiven Erique Lukong

“…We further highlight recent advances in next-generation therapeutics targeting both ERα mutants and GPER, which may offer a more effective, integrated strategy to overcome ET resistance.…”
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Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation. by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Mubashir Hassan, Andrzej Kloczkowski, Wanjoo Chun

“…In this study, we employed an integrated deep-learning model followed by traditional drug screening approach to screen a library of FDA-approved drugs, aiming to identify novel inhibitors targeting the TNF-α converting enzyme (TACE). …”
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Non-microtubular localizations of microtubule-associated protein 6 (MAP6). by Sylvie Gory-Fauré, Vanessa Windscheid, Jacques Brocard, Sylvie Montessuit, Ryouhei Tsutsumi, Eric Denarier, Yuko Fukata, Christophe Bosc, Julie Delaroche, Nora Collomb, Masaki Fukata, Jean-Claude Martinou, Karin Pernet-Gallay, Annie Andrieux

“…MAP6 proteins (MAP6s), which include MAP6-N (also called Stable Tubule Only Polypeptide, or STOP) and MAP6d1 (MAP6 domain-containing protein 1, also called STOP-Like protein 21 kD, or SL21), bind to and stabilize microtubules. MAP6 deletion in mice severely alters integrated brain functions and is associated with synaptic defects, suggesting that MAP6s may also have alternative cellular roles. …”
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HNRNPA2B1: a novel target in pulmonary arterial hypertension by Yingying Wei, Daiqin Wu, Na Deng, Fujia Xu, Sihan Luo, Xinxin Fan, Haijun Guo, Jingjing Chen, Wei Li, Xiaoyun Si

“…Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), an RNA-binding protein integral to mRNA processing and post-transcriptional regulation, governs critical processes including cell proliferation, apoptosis, angiogenesis, and endothelial homeostasis. …”
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Association between genetic variants in DNA and histone methylation and telomere length. by Sangmi Kim, Christine G Parks, Zongli Xu, Gleta Carswell, Lisa A DeRoo, Dale P Sandler, Jack A Taylor

“…Our results are consistent with recent findings that chromatin structure is epigenetically regulated and may influence the genomic integrity of telomeric region and telomere length maintenance. …”
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UNDERSTANDING THE RULE OF LAW AS A SOCIAL STATE IN THE DOMESTIC THEORY OF LAW by I. Galstyan, R. Melekaev

“…The goal of any state model, as an organization of political power, in particular, an effective social state model, is to ensure the unity and integrity of society, implemented through the state mechanism for managing the affairs of society, sovereign public power, giving the right a universally binding value guaranteeing the rights and freedoms to citizens, law and order, where efficiency is viewed through the prism of social efficiency. …”
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Computational investigation of Belzutifan drug delivery mechanisms using SiC nanocrystals via combined DFT and molecular dynamics approaches by Wael A. Mahdi, Adel Alhowyan, Ahmad J. Obaidullah

“…MD simulations confirm the complex’s stability under physiological conditions, maintaining structural integrity with root-mean-square deviation (RMSD) values below 2.5 Å throughout the 5 ps simulation. …”
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Mendelian randomization analysis reveals the potential of the IKZF1 gene as a therapeutic target in colorectal cancer by Junzuo Lin, Qian Xu, Zhengfei Zhao

“…Molecular docking and dynamics simulations confirmed the strong binding affinities of potential drugs with IKZF1. …”
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Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations. by Federica Mosti, Mariah L Hoye, Carla F Escobar-Tomlienovich, Debra L Silver

“…De novo mutations in the RNA binding protein DDX3X cause neurodevelopmental disorders including DDX3X syndrome and autism spectrum disorder. …”
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mTOR pathway targeted inhibition via Rapamycin-loaded PLGA nanoparticles for enhanced bladder cancer therapy by Nour-Elhoda El-hefnawy, Magdy M Youssef, Hassan Abol-Enein, Raghda Abo Gabal

“…Rapamycin, Everolimus, Temsirolimus and Other ATP-competitive inhibitors work by binding to the mTOR protein and preventing it from activating downstream signaling pathways that control cell growth and division. …”
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Unleashing the anti-tumor angiogenic potential of nano-formulated orientin: In Silico, In Vitro, and In Ovo studies. by Yashwanth Elumalai, Kathiresan Nachammai, Kirubhanand Chandrasekaran, Langeswaran Kulanthaivel, Sharon Benita Stephen, Kanu Shil, Ram Kumar Anandan, Abdulhadi Ibrahim Bima, Zeenath Khan, Abdulhadi S Burzangi, Noor A Shaik, Nuha Al-Rayes, Gowtham Kumar Subbaraj

“…After nano-formulation, UV spectroscopy confirmed the integrity of orientin with no shift in the λmax (347 nm). …”
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Regional culture: Representations and possibilities for study by Irina Ya. Murzina

“…The history of the Ural culture is a vivid example of the formation and development of a regional culture. Being an integral part of the culture of Russia, at the same time, it is a relatively independent phenomenon with its own laws and logic of development. …”
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Neurobeachin regulates receptor downscaling at GABAergic inhibitory synapses in a protein kinase A-dependent manner by Felix P. Lützenkirchen, Yipeng Zhu, Hans M. Maric, Dominik S. Boeck, Kira V. Gromova, Matthias Kneussel

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Targeted modulation of MMP9 and GRP78 via molecular interaction and in silico profiling of Curcuma caesia rhizome metabolites: A computational drug discovery approach for cancer th... by Mahek Desai, Soham Bhattacharya, Saurabhkumar Mehta, Kaushiki Joshi, Mitesh B Solanki, Trilok Akhani, Iva Viehmannová, Eloy Fernández Cusimamani

“…This study employs a structure-based drug design approach, integrating molecular docking, molecular dynamics (MD) simulations, and in silico profiling, to investigate the anti-cancer potential of metabolites from Curcuma caesia rhizomes. …”
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Differential Expression of Serum Proteins in Rats with Allergic Asthma: A Study Based on the Nanoliter Two-Dimensional Liquid Chromatography Technique by Xingke Yan, Ao Zhang, Lu Yu, Cheng Chen, Haifu Cui

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Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro by Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson

“…Our data suggest that immune sera stimulates multiple interrelated secretory mechanisms to maintain the integrity of the tegumental barrier in response to immune attack. …”
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Single-Cell Transcriptome Analysis Defines Expression of Kabuki Syndrome-Associated KMT2D Targets and Interacting Partners by Badam Enkhmandakh, Paul Robson, Pujan Joshi, Anushree Vijaykumar, Dong-Guk Shin, Mina Mina, Dashzeveg Bayarsaihan

“…In addition, we found that Kmt2d and Kdm6a coexpress with the downstream target genes of the Wingless and Integrated (WNT) and sonic hedgehog signaling pathways in mesenchymal stem/stromal cells (MSCs) at different stages of osteogenic differentiation. …”
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