A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation by Dana Segal, Samy Coulombe, Jasper Sim, Josée Dostie

“…HOXA1 depletion similarly perturbed expression of these pluripotent factors, suggesting that HOTAIRM1 is a modulator of this transcription factor pathway. Also, given that binding of HOTAIRM1 to HOXA1 was observed in different cell types and species, our results point to this ribonucleoprotein complex as an integral part of a conserved HOTAIRM1-HOXA1 regulatory axis modulating the transition from a pluripotent to a differentiated neuronal state.…”
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A Network Pharmacology Study and In Vitro Evaluation of the Bioactive Compounds of <i>Kadsura coccinea</i> Leaf Extract for the Treatment of Type 2 Diabetes Mellitus by Ying Wang, Shuizhu Cai, Wenzhao Wen, Yanhui Tan, Wenwen Wang, Jing Xu, Ping Xiong

“…These targets (especially AKT1 and TNF) have a high binding affinity with the main active ingredients of KCLE (rutin, luteolin, demethylwedelolactone, maritimetin, and polydatin). …”
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Machine learning unveils hypoxia-immune gene hub for clinical stratification of thyroid-associated ophthalmopathy by Lu Chen, Sha Wang, Jinwei Wang, Bei Xu, Jia Tan, Xiaobo Xia

“…This study focused on the role of hypoxia in its pathogenesis through integrative bioinformatics and experimental validation. …”
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Multiplexed proteomic biosensor platform for label-free real-time simultaneous kinetic screening of thousands of protein interactions by Chidozie Victor Agu, Rebecca L. Cook, William Martelly, Lydia R. Gushgari, Mukilan Mohan, Bharath Takulapalli

“…Monoclonal antibodies were found to selectively bind their SPOC protein targets and anti-RBD antibody was used to demonstrate discriminated binding kinetics to numerous SARS-CoV-2 RBD variants on-chip. …”
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Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management by Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen

“…Through molecular docking screening of 389 natural compounds, we identified isorhamnetin-3-O-neohespeidoside as a potent dual inhibitor, demonstrating superior binding affinities (-8.001 kcal/mol for TYR and − 7.342 kcal/mol for MC1R) compared to arbutin (reference compound). …”
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Improvement in the Thermal Stability of <i>Is</i>MHETase by Sequence and Structure-Guided Calculation by Shuyan Duan, Tianzhu Chao, Yaoyao Wu, Zhaoyi Wei, Sheng Cao

“…Sequence and structural analyses indicate that, among these seven proteins, all amino acids within 5 Å of the substrate-binding site are identical, with the exception of Ser131 and Phe415. …”
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INDICATION OF THE BIOCHEMICAL TARGETS OF RARE EARTH ELEMENTS IN BIVALVE MOLLUSCS UNDER MULTIPLE EXPOSURE by V. Khoma, K. Yunko, V. Martyniuk, M.Zarian, V. Havryshkiv

“…The lysosomal membrane integrity and apoptotic activity decreased only in the Gd-group. …”
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A three-way transcriptomic crosstalk interaction in a biocontrol agent (Bacillus velezensis), a fungal pathogen (Colletotrichum gloeosporioides), and a walnut host (Juglans regia L... by Shiwei Wang, Hanmingyue Zhu, Shuying Li, Tianhui Zhu

“…We identified 111,674, 799, and 79 differentially expressed genes (DEGs) in walnut, C. gloeosporioides, and B. velezensis respectively. By integrating WGCNA and PPI network analyses, we discovered 3 key modules and 10 hub genes in C. gloeosporioides, and 2 key modules and 2 hub genes in B. velezensis. …”
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TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2 by Gang Yu, Wanjing Chen, Xianghua Li, Liang Yu, Yanyan Xu, Qiang Ruan, Yawei He, Yong Wang

“…Mechanistically, the COL1A2 promoter has a distinct H3K27ac modification site and that E1A binding protein p300 (EP300) and twist family bHLH transcription factor 1 (TWIST1) can bind to the COL1A2 promoter, which in turn transcriptionally activated COL1A2 expression. …”
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Circular RNAs in inflammatory bowel disease: a review of mechanisms, biomarkers and therapeutic potential by Le Yang, Huahui Li, Min Tang, Lingnan He, Lijun Yang

“…In this review, we comprehensively synthesize recent advancements in circRNA research related to IBD, integrating evidence from in vitro, in vivo, and clinical studies. …”
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Genome-wide analysis of the AarPDR gene family in Artemisia argyi and its potential role in regulating terpenoids transport by Xiaoyu Han, Min Cui, Shuangxin Ma, Xuemei Gao, Liping Tang, Bin Li

“…Conclusions The AarPDRs were characterized by integrating genome analysis, transcriptome, and metabolite profiling. …”
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Antimicrobial Activity of Lavender Essential Oil from <i>Lavandula angustifolia</i> Mill.: In Vitro and In Silico Evaluation by Sylvia Stamova, Neli Ermenlieva, Gabriela Tsankova, Emilia Georgieva

“…Furthermore, molecular docking analysis revealed a high binding affinity of linalool and linalyl acetate towards the FabI protein of <i>E.coli</i>, suggesting a potential inhibitory mechanism at the molecular level.…”
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From the Test Tube to the Cell: A Homecoming for DNA Computing Circuits? by Hyeyun Jung, Ethan Collinson, Alexander Patrick Hawes, Harold Fellermann

“…This comprises cellular nucleic acids such as messenger RNA and microRNA, as well as other biological molecules that can trigger DNA nanodevices through the aid of aptamer binding. We investigate challenges and recent successes of operating DNA strand displacement devices in cellular lysates as well as delivering or integrating DNA nanodevices into cells. …”
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Mechanisms of Jisheng-Wumei tablet in laryngeal cancer treatment: a network pharmacology analysis of baicalein’s targeting of cytochrome C for laryngeal cancer inhibition by Quanwei Ren, Xiaoli Luo, Chao Yu, Yilin Xiang, Di Wu, Yanli Zhao, Zhongwan Li

“…Key targets were identified through survival analysis of TCGA expression data, and molecular docking was employed to evaluate the binding affinity between JSWMT compounds and these targets. …”
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New approach methodologies for risk assessment using deep learning by Enol Junquera, Irene Díaz, Susana Montes, Ferdinando Febbraio

“…We will also validate the developed NAMs by integrating existing in vivo information from scientific literature and technical reports. …”
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Development of Automated Exosome Isolation Method Using Epigallocatechin Gallate-Modified Magnetic Beads: Standardized Protocols for Diverse Biofluids by Heejong Shin, Eunju Jeong, Seunggwan Lee

“…We systematically investigated the optimal EGCG:T-Fe₃O₄ ratio (0.1:1), binding time, elution parameters, and extraction buffer composition for each biofluid type. …”
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Tunnels under geometries (or instantons know their algebras) by Dmitry Galakhov, Alexei Morozov

“…Abstract In the tight binding model with multiple degenerate vacua we might treat wave function overlaps as instanton tunnelings between different wells (vacua). …”
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353 Harnessing computational tools to rank vaccine targets in Plasmodium falciparum candidate antigens by Alexander Laurenson, Matthew Laurens

“…We designed and used heuristic-based and AI-weighting models that integrated predicted binding affinities to HLA alleles, HLA allele frequency data, and sequence conservation to score and rank targets. …”
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AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders by Daniel Choquet, Patricio Opazo, Hongyu Zhang

“…This approach underscores an integrated therapeutic target amidst the complexity of these neurodegenerative and neuropsychiatric diseases.…”
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Research Progress on the Mechanism of Ketamine in Neuropathic Pain Comorbid Depression by Li Q, Liu S, Qin B, Liu X

“…The structure and function of NMDA receptors, as well as the binding sites of ketamine, are summarized, and the hypothesis of disinhibition and neuroplasticity of ketamine’s antidepressant effect is elaborated. …”
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