Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition by Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li

Get full text

Evaluation of the pharmacological potential of N-((5-phenyl-6,11-dihydro-[1,2,4]triazolo[1’,5’:1,6]pyrido[3,4-b]indol-2-yl)methyl)benzamides by S. O. Fedotov

“…Docking simulations were conducted with AutoDock Vina, enabling accurate modeling of ligand-protein binding based on energetic and steric complementarity. …”
Get full text

Tislelizumab in Chinese patients with advanced solid tumors: an open-label, non-comparative, phase 1/2 study by Lin Shen, Qing Zhou, Ting Sun, Jie Wang, Hongming Pan, Yi-Long Wu, Jun Zhao, Jun Guo, Qingyuan Zhang, Ying Yuan, Yuxian Bai, Tianshu Liu, Yongqian Shu, Siyang Wang, Aiping Zhou, Dingwei Ye, Yujuan Gao, Silu Yang, Zuobai Wang

Get full text

Computation strategies and clinical applications in neoantigen discovery towards precision cancer immunotherapy by Zhenchang Wang, Yu Gu, Xiao Sun, Hao Huang

“…Here, we presented a comprehensive review of integrated neoantigen prediction algorithms, encompassing task definition, theoretical developments, benchmark datasets, cutting-edge applications, and future research directions. …”
Get full text

A novel rapid rule-out protocol for acute chest pain using H-FABP point-of-care testing by Ozan Demirel, Michael Krainz, Uta C. Hoppe, Moritz Mirna

“…The purpose of this study was to develop a rapid rule-out strategy for patients with acute chest pain that integrates clinical characteristics and Heart-type fatty acid binding protein (H-FABP) to improve ED patient care. …”
Get full text

Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders by Cassandra A. Cairns, Lan Xiao, Jian-Ying Wang

“…Effective therapies for the preservation of intestinal epithelial integrity and for the prevention of mucosal hemorrhage and gut barrier dysfunction are limited, primarily because of a poor understanding of the mechanisms underlying mucosal disruption. …”
Get full text

The Proteome Content of Blood Clots Observed Under Different Conditions: Successful Role in Predicting Clot Amyloid(ogenicity) by Douglas B. Kell, Etheresia Pretorius

Get full text

An immunoinformatics and extensive molecular dynamics study to develop a polyvalent multi-epitope vaccine against cryptococcosis. by Md Razwan Sardar Sami, Nurul Amin Rani, Mohammad Mahfuz Enam Elahi, Mohammad Sajjad Hossain, Minhaz Abdullah Al Mueid, Zahidur Rahim, Rajesh B Patil, Abu Tayab Moin, Israt Jahan Bithi, Sabekun Nahar, Israt Jahan Konika, Sneha Roy, Jannatul Aleya Preya, Jamil Ahmed

“…Following this analysis, we designed two vaccine constructs integrating a compatible adjuvant and suitable linkers. …”
Get full text

The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis by Mamoru Aoto, Hiroshi Sakai, Naohito Tokunaga, Mei Miyazaki, Takeshi Kiyoi, Nobutaka Ohkubo, Yuuki Imai, Noriaki Mitsuda

Get full text

Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4. by Mamantia Constantinou, Evelina Charidemou, Izge Shanlitourk, Katerina Strati, Antonis Kirmizis

“…The DNA damage response (DDR) constitutes a vital cellular process that safeguards genome integrity. This biological process involves substantial alterations in chromatin structure, commonly orchestrated by epigenetic enzymes. …”
Get full text

ROLE OF ULTRASOUND IN MECHANISMS OF ANODE-CATHODE INTERACTIONS DURING ELECTROSPARK ALLOYING by N. M. Chigrinova, S. I. Lovygin, V. E. Chigrinov

“…Methodology of the executed research activity has been based on integrated studies (gravimetric, metallographic, X-ray diffraction and electron microscopic) of coatings which are to be formed through compositions produced while using method of high-energy hot compaction and a “refractory carbide (WC) and a binding material“ system in the form of alloy based on nickel from the series of “colmonoy” Ni – Ni3B system which is alloyed with additions of copper and silicon. …”
Get full text

Surface expression of metallothionein enhances bioremediation in Escherichia coli by Nan He, Wenbing Yao, Liu Tang

Get full text

SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics by Gülkiz Baytek, Alexander Blume, Funda Gerceker Demirel, Selman Bulut, Oliver Popp, Philipp Mertins, Baris Tursun

“…Histone proteins are integral chromatin components, and their modification promotes gene expression regulation. …”
Get full text

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere by Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett

“…Our results reveal the DBHS protein family as components of the telomerase trafficking machinery integral to telomere maintenance.…”
Get full text

BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis by Lixin Liu, Li Xiong, Hong Peng, Qin Deng, Kang Liu, Shusen Xia

“…Mechanistically, BNC1 suppresses CCL20 expression by binding to its promoter, leading to reduced activation of the JAK-STAT signaling pathway and promoting apoptosis in gastric cancer cells. …”
Get full text

DTA Atlas: A massive-scale drug repurposing database by Madina Sultanova, Elizaveta Vinogradova, Alisher Amantay, Ferdinand Molnár, Siamac Fazli

“…To the best of our knowledge, DTA Atlas represents the first comprehensive collection of drug-target binding strength predictions. It is open-source and can serve as an important resource for drug development, drug repurposing, toxicity studies and more.…”
Get full text

QSAR, docking and pharmacokinetic studies of 2,4-diphenyl indenol [1,2-B] pyridinol derivatives targeting breast cancer receptors by Auwal Isa, Adamu Uzairu, umar Umar, Muhammad Tukur Ibrahim, Abdullahi Umar

“…Molecular docking investigations explore interactions between 2,4-diphenyl indenol [1,2-b] pyridinol derivatives and breast cancer receptors (2RMJ, 4OAR, 4RDH, 3ERT). Remarkable binding patterns are observed, insinuating at potential DNA gyrase inhibition. …”
Get full text

Interdependence of Pasha and Drosha for localization and function of the Microprocessor in C. elegans by Thiago L. Knittel, Brooke E. Montgomery, Kailee J. Reed, Madeleine C. Chong, Ida J. Isolehto, Erin R. Cafferty, Margaret J. Smith, Reese A. Sprister, Colin N. Magelky, Hataichanok Scherman, René F. Ketting, Taiowa A. Montgomery

“…Our results reveal a mutual dependency between Pasha and Drosha for their localization in C. elegans and highlight the role of Pasha’s WW domain in maintaining Microprocessor integrity.…”
Get full text

Synthesis, X-ray diffraction analysis, quantum chemical studies and α-amylase inhibition of probenecid derived S-alkylphthalimide-oxadiazole-benzenesulfonamide hybrids by Bilal Ahmad Khan, Syeda Shamila Hamdani, Muhammad Naeem Ahmed, Shahid Hameed, Muhammad Ashfaq, Ahmed M. Shawky, Mahmoud A. A. Ibrahim, Peter A. Sidhom

“…Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. …”
Get full text

Prevalence of transcription promoters within archaeal operons and coding sequences by Tie Koide, David J Reiss, J Christopher Bare, Wyming Lee Pang, Marc T Facciotti, Amy K Schmid, Min Pan, Bruz Marzolf, Phu T Van, Fang‐Yin Lo, Abhishek Pratap, Eric W Deutsch, Amelia Peterson, Dan Martin, Nitin S Baliga

“…A significant fraction of these alternate transcriptional events correlate to binding locations of 11 transcription factors and regulators (TFs) inside operons and annotated genes—events usually considered spurious or non‐functional. …”
Get full text