Dual role of natural molecules in bridging cancer and Alzheimer’s disease: insights from in silico simulations by Nigar Kantarci-Carsibasi, Munteha Girgin

“…These molecules demonstrate interactions with key residues in the ERα binding site such as Glu 353 and Phe 404 through hydrogen bonding and pi-pi stacking. …”
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A phage-encoded counter-defense inhibits an NAD-degrading anti-phage defense system. by Christian L Loyo, Alan D Grossman

“…Using genetic and biochemical analyses, we found that SpbK is an NADase that is activated by binding to the SPβ phage portal protein YonE. The presence of YonE stimulates NADase activity of the TIR domain of SpbK and causes cell death. …”
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DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts by Susan T. Lovett

“…The holC gene encodes an accessory protein (known as χ) to the core clamp loader complex and is the only protein of the holoenzyme that binds to single-strand DNA binding protein, SSB. …”
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In silico modeling of zerumbone as a multi-target therapeutic for lung disorders with experimental characterization of its purity and thermal stability by Nourhan Elsayed

“…Analytical characterization using FTIR, GC-MS, TGA, and DSC confirmed ZER’s purity, chemical integrity, and thermal stability, further supporting its pharmaceutical application. …”
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COMPUTER SIMULATION OF GLICOPHORIN A AND 4-METHYL-2,6-DIISOBORNILFENOL INTERACTION BY AUTODOCK AND HEXSERVER PROGRAMS by O. I. Ostrikova

“…We used the electrostatic properties of the molecule glycophorin A, site of interaction is position chain A VAL83, chain B – ALA82, GLY83, GLY86, THR87. The energy of binding was –6.73 kcal/mol by AutoDock program, HexServer – –2.89 kcal/mol. …”
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Revolutionizing CRISPR technology with artificial intelligence by Min-gyeong Kim, Min-ji Go, Seung-Hun Kang, Soo-hwan Jeong, Kayeong Lim

“…Abstract Genome engineering has made remarkable strides, evolving from DNA-binding proteins such as zinc fingers and transcription activator-like effectors to CRISPR–Cas systems. …”
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Exploring the molecular mechanism of budesonide enteric capsules in the treatment of IgA nephropathy based on bioinformatics by Mengshu Lin, Shengji Chen, Yixuan Chen, Qing Gao

“…In this study, we utilized bioinformatics approaches to integrate data from the GeneCards, CTD, and OMIM databases, identifying 787 IgAN-related targets. …”
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When a ribosomal protein grows up – the ribosome assembly path of Rps3 by Brigitte Pertschy

“…R-proteins usually have composite rRNA binding sites, with several different rRNA helices contributing to the full interaction. …”
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Multiplex Eukaryotic Transcription (In)activation: Timing, Bursting and Cycling of a Ratchet Clock Mechanism. by Katja N Rybakova, Frank J Bruggeman, Aleksandra Tomaszewska, Martijn J Moné, Carsten Carlberg, Hans V Westerhoff

“…We find that the assembly of large transcription factor complexes on chromatin via equilibrium-binding mechanisms is highly inefficient and insensitive to concentration changes of single regulatory proteins. …”
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Improving the solubility of remdesivir–cyclodextrin encapsulations in water-saturated 1-octanol solution: A molecular dynamics simulation study by Sani Ega Priani, Aulia Fikri Hidayat, Taufik Muhammad Fakih

“…Molecular docking results indicated that the complexes of remdesivir with HPBCD and SBCD exhibited the lowest binding energies of −10.69 kcal/mol and −8.34 kcal/mol, respectively. …”
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Harnessing machine learning for high-entropy alloy catalysis: a focus on adsorption energy prediction by Qi Wang, Yonggang Yao

“…Among these properties, adsorption energy, which quantifies the binding strength between catalytic intermediates and surface sites, is a crucial indicator of catalytic activity. …”
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Obesity induced transcriptional changes in skeletal muscle across different species. by Yujie Wang, Jiaman Zhang, Xintong Yang, Fuwen Wang, Long Jin, Jing Li, Xuewei Li, Mingzhou Li

“…This study constructs the skeletal muscle transcriptome of obese pigs and integrates it with publicly available transcriptional profiles from obese humans and mice, and ATAC-seq data from lean individuals across species. …”
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Targeting TP53TG1: a promising prognostic biomarker and therapeutic target for personalized cancer therapy by Haodong He

“…TP53TG1 modulates gene expression by several mechanisms, including “competitive RNA” activity, competitive miRNA binding, control of critical signaling pathways, and facilitation of epigenetic changes. …”
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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets. by Venkateswarlu Kanamarlapudi, Sian E Owens, Keya Saha, Robert J Pope, Stuart J Mundell

“…In this study we investigated the role of the small GTP-binding protein ADP ribosylation factor 6 (ARF6) in the internalization and function of P2Y(1) and P2Y(12) purinoceptors in human platelets. …”
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Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects by Jose Crespo-Barrios

“…This article proposes an integrative approach, Vaxtherapy, to tackle these mechanisms. …”
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Investigating the role of tumor cell heterogeneity and angiogenesis genes in the prognosis of multiple myeloma by Xue Qiao, Zhengrong Song, Li Geng, Lina Xing, Ying Wang

“…Notably, high expression of the transcription factor cAMP-responsive element-binding protein 3-like 2 (CREB3L2) in the C1 subgroup was associated with the inhibition of angiogenesis and tumor cell proliferation and migration. …”
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ANALYSIS OF OPERATION AND RESEARCH OF THE ENERGY CHARACTERISTICS ROTARY DISPERSER by Rudnev S.D., Kozlov M.A., Kryuk R.V.

“…An approach to determining the energy balance of the components in terms of physical size, easily accessible for direct measurements without the use of specialized tools and methods and binding costs of available capacity on the dispersion of the characteristics of the process - the multiplicity of processing and degree of grinding object of study is a model mixture is a suspension of the pulp of carrots water in a concentration of 5 mass%. …”
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Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice by Yu Ishikawa-Yamauchi, Chihiro Emori, Hideto Mori, Tsutomu Endo, Kiyonori Kobayashi, Yuji Watanabe, Hiroshi Sagara, Takeshi Nagata, Daisuke Motooka, Akinori Ninomiya, Manabu Ozawa, Masahito Ikawa

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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…Methods Chromatin immunoprecipitation (ChIP)‐sequencing was integrated with RNA sequencing to identify SE‐regulated target genes in hypoxic PASMCs. …”
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Cyclodextrin host-guest complexes-derived exosomal miRNAs for enhancing the antifatigue effects of resveratrol by Hurong Ge, Peipei Ma, Qing Huang, Shijie Wei, Zhizhong Wang

“…., and cellular components such as membrane, cytoplasm, integral component of membrane, etc., and molecular functions are closely related to protein binding, metal ion binding, molecular_function, etc.; mainly enriched in Axon guidance, MicroRNAs in cancer, Apoptosis and other signalling pathways. …”
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