A multi-modal transformer for predicting global minimum adsorption energy by Junwu Chen, Xu Huang, Cheng Hua, Yulian He, Philippe Schwaller

“…Additionally, uncertainty quantification was integrated into our models to enhance the trustworthiness of the predictions.…”
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Lipid-mediated hydrophobic gating in the BK potassium channel by Lucia Coronel, Giovanni Di Muccio, Brad S. Rothberg, Alberto Giacomello, Vincenzo Carnevale

“…Our results highlight an unexpected role for annular lipids, which appear to be an integral part of the gating machinery. In the Ca2+ −free (“closed”) pore, methyl groups from lipid alkyl chains can enter the pore through fenestrations between the pore-lining helices. …”
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Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats by Nan Shang, Xiaoyu Bao, Michael Doschak, Jianping Wu

“…Ovotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. …”
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Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC by Miguel Montez, Danling Zhu, Jan Huertas, M. Julia Maristany, Bas Rutjens, Mathias Nielsen, Rosana Collepardo-Guevara, Caroline Dean

“…Our work highlights how local nucleosome dynamics link to chromatin structure transitions to integrate temperature inputs into epigenetic switching mechanisms in plants.…”
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Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis by Roaa Tarek Elbannan, Hannan Kamal Abdelaziz, Eman Ahmed Shaat, AM Ibrahim, Hend A. yassin

“…Abstract Background Circular RNAs are stable non-coding RNAs that regulate biological processes via sponging microRNAs, interacting with RNA binding proteins, as well as controlling gene expression. …”
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In silico characterization of Ciwujianoside E: Structural features, solvation dynamics, and eco-toxicological assessment by A. Marta Navarro-Cuñado, María J. Tapia, Sergio de-la-Huerta-Sainz, Alberto Gutiérrez, Santiago Aparicio

“…This study includes electron density distributions and topological characteristics defining the structural integrity, along with a detailed hydrogen bonding network analysis. …”
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Graphene–Bacteriophage Hybrid Nanomaterials for Specific and Rapid Electrochemical Detection of Pathogenic Bacteria by José M. Campiña, António F. Silva, Carlos M. Pereira

“…Recently, electrochemical biosensors integrating graphene nanomaterials with bacteriophages—termed graphages—have emerged as promising platforms for pathogen detection, offering fast, specific, and highly responsive detection. …”
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Key Amino Acid Residues of the Agt1 Transporter for Trehalose Transport by <i>Saccharomyces cerevisiae</i> by Anqi Chen, Yuhan Cheng, Liushi Meng, Jian Chen

“…The Agt1 transporter, a member of the Major Facilitator Superfamily, mediates trehalose uptake, a key process for maintaining cellular integrity under stress. Despite its importance, the molecular mechanisms of Agt1-mediated trehalose transport remain underexplored. …”
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Judicial Responses to World Health Organization Norms: A Comparative Analysis of General Repercussion Cases from the Brazilian Federal Supreme Court and the Indian Supreme Court by Alex Silva Oliveira, Narender Kumar

“…One of the main findings is that Brazil generally integrates a wide range of WHO norms directly into its legal system, whereas India tends to use them more as complementary guidelines. …”
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Screening of SIRT2 inhibitors from natural product databases using computer-aided drug design and molecular dynamics simulation by Tianyi Liu, Hongli Yin, Xue Dong, Qingyang Hu, Xuejiao Hu, Wenxin Yan, Huanhuan Wang, Zhong Li

“…A comprehensive computer-aided drug design platform has been successfully established by integrating various techniques such as drug-likeness screening, pharmacokinetic prediction, molecular docking, and molecular dynamics simulation. …”
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An on‐chain trading model of real world asset backed digital assets by Dongsheng Hou, Wenjing Ma, Wei Zhang, Yixuan Li, Yu Du, Yukun Hao

“…To improve the current status of NFTs as static assets, a token protocol binding each NFT with a unique account address was proposed. …”
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Transcriptome analysis reveals a de novo DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development by Adaobi Okafor, Yagoub Adam, Benedikt Brors, Ezekiel Adebiyi

“…We interpreted these motifs using known binding sites for eukaryotic transcription factors including ApiAP2 proteins. …”
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Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus by Joshua Hefler, Cheng-Wei Wu, Kenneth B. Storey

“…Commonly known as a tumor suppressor, it is responsible for initiating diverse actions to protect the integrity of the genome, ranging from cell cycle arrest to apoptosis. …”
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Characterization of Coelenterazine Analogs for Measurements of Luciferase Activity in Live Cells and Living Animals by Hui Zhao, Timothy C. Doyle, Ronald J. Wong, Yuan Cao, David K. Stevenson, David Piwnica-Worms, Christopher H. Contag

“…All CLZN analogs tested showed higher auto-oxidation signals in serum than was observed in phosphate buffer or medium, mainly as a result of auto-oxidation by binding to albumin. CLZN- f , -h , and -e analogs showed 4- to 8-fold greater Rluc activity, relative to CLZN- native , in cells expressing the enzyme from a stable integrant. …”
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The Tension between Cultural Heritage and Individual Freedom: The JiLu Marriage Tradition among the Indigenous Javanese Community in Blembem, Ponorogo by Muhammad Jazil Rifqi, Alfina Aulia Zulfa, M. Alfian Alana, Ahmad Fauzan Syakuri

“…Although JiLu lacks a formal legal or religious foundation, it continues to function as a binding social norm upheld through oral tradition, communal belief systems, and social sanctions. …”
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Wuzhuyu Decoction Relieves Chronic Migraine by Regulating 5-HT1A and 3A Receptors-Mediated CREB Signaling Pathway in Brain and Intestine by Zhimin Song, Meijing Li, Ziwei Zhou, Xiaomeng Guo, Qi Wang, Zekuan Zhang, Keshu Wang, Qixiang Zheng, Wenjing Gou, Sha Wu, Hui Zhao, Muxin Gong

“…On this basis, the protein expression levels of 5-HT1A/3A receptors and their cAMP-response element binding protein (CREB) signaling pathway were detected by western blot and immunohistochemistry. …”
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Designing of a Novel Aerolysin-based Multiepitope Vaccine against Aeromonas hydrophila Isolated from Osphronemus goramy Using Reverse Vaccinology: an in Silico Approaches by Rozi, Wiwiek Tyasningsih, Jola Rahmahani, Eduardus Bimo Aksono, Muchammad Yunus, Mohammad Anam Al-Arif, Suryo Kuncorojati, Rahayu Kusdarwati, Putri Desi Wulan Sari, Mohammad Noor Azmai Amal, Annas Salleh, Nadeem Khanand, Suwarno

“… • In silico simulations demonstrated that the MEV has a strong binding affinity to immune receptors like TLR-4, MHC-I, and MHC-II, indicating its potential to induce robust cellular and humoral immunity…”
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Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation by Hailing Liu, Lei Xu, Shiwei Yue, Hongfei Su, Xing Chen, Qiumeng Liu, Hui Li, Huifang Liang, Xiaoping Chen, Jiefeng He, Zeyang Ding, Bixiang Zhang

“…To explore the underlying mechanisms of NAT10‐ac4C in HCC, we employed a comprehensive approach integrating acetylated RNA immunoprecipitation and sequencing, RNA sequencing and ribosome profiling analyses, along with RNA immunoprecipitation, RNA pull‐down, mass spectrometry, and site‐specific mutation analyses. …”
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Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms. by Kaiyu Chen, Sikou Shen, Zhimeng Lv, Ming Guo, Yina Shao, Chenghua Li

“…Cleaved AjMLKL18-491 displayed higher binding affinities towards phosphatidylinositol phosphate and cardiolipin compared to those of un-cleaved form. …”
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Coating of Remdesivir and Ivermectin on silver nanoparticles: A density functional theory and molecular dynamics study by Razieh Morad

“…These results suggest that Remdesivir-coated AgNPs offer enhanced stability, while Ivermectin may allow for controlled drug release. By integrating DFT and MD approaches, this study provides a theoretical framework for optimizing AgNP-based drug delivery systems. …”
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