Escherichia coli O127 group 4 capsule proteins assemble at the outer membrane. by Matthew R Larson, Kassia Biddle, Adam Gorman, Sarah Boutom, Ilan Rosenshine, Mark A Saper

“…GfcC and GfcB form a high-affinity heterodimer with a KD near 100 nM. This heterodimer binds to GfcD (KD = 28 μM) significantly better than either GfcB or GfcC alone. …”
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Response regulator heterodimer formation controls a key stage in Streptomyces development. by Mahmoud M Al-Bassam, Maureen J Bibb, Matthew J Bush, Govind Chandra, Mark J Buttner

“…Additional ChIP-Seq analysis showed that BldM Group II genes were also direct targets of WhiI and that in vivo binding of WhiI to these promoters depended on BldM and vice versa. …”
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A Rfa1-MN-based system reveals new factors involved in the rescue of broken replication forks. by Ana Amiama-Roig, Marta Barrientos-Moreno, Esther Cruz-Zambrano, Luz M López-Ruiz, Román González-Prieto, Gabriel Ríos-Orelogio, Félix Prado

“…The integrity of the replication forks is essential for an accurate and timely completion of genome duplication. …”
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Identification of novel therapeutic targets in hepatitis-B virus-associated membranous nephropathy using scRNA-seq and machine learning by Yongzheng Hu, Qian An, Xinxin Yu, Wei Jiang

“…Integrating scRNA-seq with machine learning offers valuable insights into the molecular landscape of HBV-MN, paving the way for novel interventions.…”
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Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice. by James L Searcy, Thierry Le Bihan, Natalia Salvadores, James McCulloch, Karen Horsburgh

“…The structural integrity of cerebral vessels is compromised during ageing. …”
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Hygroscopic properties modeling and thermodynamic analysis of a seamless popping capsule by Shuo Li, Hui Ge, Hongqiang Wang

“…Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) identified moisture-binding sites, and Scanning Electron Microscopy (SEM) revealed structural changes due to moisture exposure. …”
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Looking into Abnormal Co-Expressions of Tau and TDP-43 in the Realm of Mixed Dementia Types: A Double-Punch Scenario by Hossam Youssef, Carina Weissmann, Gokhan Uruk, Rodolfo Gabriel Gatto

“…Transactive response DNA-binding protein of 43 kDa (TDP-43) and tau proteins play critical roles in neurodegenerative diseases, particularly frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD). …”
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Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects by Hayder A. Giha, Rabab A. Abdulwahab, Jaafar Abbas, Zakia Shinwari, Ayodele Alaiya

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Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. by Musa A Hassan, Kirk D Jensen, Vincent Butty, Kenneth Hu, Erwan Boedec, Pjotr Prins, Jeroen P J Saeij

“…In addition, we show that the difference between AJ and C57BL/6J macrophages in controlling Toxoplasma growth after stimulation with interferon gamma and tumor necrosis factor alpha mapped to chromosome 3, proximal to the Guanylate binding protein (Gbp) locus that is known to modulate the murine macrophage response to Toxoplasma. …”
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Targeting dysregulated molecular pathways in cancer cell lines using small molecule inhibitors as a promising therapeutic strategy by Hassan H Almasoudi, Shoaib Khan

“…To elucidate the underlying mechanism of action, molecular docking studies were conducted to analyze ligand–target interactions at the atomic level, revealing favorable binding conformations within key regulatory proteins implicated in oncogenesis. …”
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Gold Nanoparticle-Enhanced Molecularly Imprinted Polymer Electrode for Non-Enzymatic Lactate Sensing by Christopher Animashaun, Abdellatif Ait Lahcen, Gymama Slaughter

“…We are reporting the development of a high-performance, non-enzymatic electrochemical biosensor for selective lactate detection, integrating laser-induced graphene (LIG), gold nanoparticles (AuNPs), and a molecularly imprinted polymer (MIP) synthesized from poly(3,4-ethylenedioxythiophene) (PEDOT). …”
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A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies by Fahsai Nakarin, Kayla G. Sprenger

“…This review reassesses affinity-based selection models and proposes a new paradigm that integrates multifactorial processes, including stochastic B cell decisions within GC dynamics, antigen extraction efficiency influenced by probabilistic bond rupture, and avidity-driven BCR binding alterations and representations on multivalent antigens. …”
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Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly. by Pingzhi Zhao, Xuan Zhang, Yuqing Gong, Duan Wang, Dongqing Xu, Ning Wang, Yanwei Sun, Lianbo Gao, Shu-Sheng Liu, Xing Wang Deng, Daniel J Kliebenstein, Xueping Zhou, Rong-Xiang Fang, Jian Ye

“…Moreover, PIFs interact with MYC2 to integrate light and jasmonate signaling and regulate the transcription of terpene synthase genes. …”
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Fabrication and characterization of carbon and glass fiber reinforced thermoplastic composites by fused filament fabrication by Dilşad Akgümüş Gök, Berk Dinçer Akay

“…SEM–EDS and FTIR analyses supported optimal binding and dispersion at 1–3% reinforcement ratios. …”
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Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease by Akanksha Bhatnagar, Christina M. Thomas, Gu Gu Nge, Aprem Zaya, Rohan Dasari, Neha Chongtham, Bijaya Manandhar, Sandhya Kortagere, Felice Elefant

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Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements by Shikha Shikha, Victor Tobiasson, Mariana Ferreira Silva, Jana Ovciarikova, Dario Beraldi, Alexander Mühleip, Lilach Sheiner

“…We reveal that poly-A tails added to rRNA molecules are integrated into the ribosome, and we demonstrate their essentiality for mitoribosome formation and for parasite survival. …”
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Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis by Tianyu Zhang, Tao Wang, Kuangyang Yu, Changren huang, Kunyang Bao

“…Molecular docking demonstrated strong binding affinities between aspartame and these targets, suggesting direct modulation. …”
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Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1 by Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen, Melinda M. Diver

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An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia by Md Selim Reza, Chuan Qiu, Xu Lin, Kuan‐Jui Su, Anqi Liu, Xiao Zhang, Yun Gong, Zhe Luo, Qing Tian, Martin Nwadiugwu, Shaung Liang, Hui Shen, Hong‐Wen Deng

“…Additionally, MTA‐MO integrates human protein–protein interaction (PPI) networks and drug‐target networks to improve target identification. …”
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Synthesis and Evaluation of ⁶⁸Ga- and ¹⁷⁷Lu-Labeled [diF-Pro¹⁴]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Pe... by Lei Wang, Chao-Cheng Chen, Devon Chapple, Antonio A. W. L. Wong, Sara Kurkowska, Wing Sum Lau, Carlos F. Uribe, François Bénard, Kuo-Shyan Lin

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