Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in ovar... by Jie Xu, Yifei Ren, Jiayi Lu, Fengjiang Qin, Dan Yang, Chunyan Tang, Yu Yang, Jing Xu, Tao Liu, Ping Yi

“…Methods We analyzed the expression of 12 146 pseudogenes and comprehensively examined the m6A modification of RNAs derived from them and their paralogs. Through integrative analysis of multi‐omics data, we explored the associations between pseudogene dysregulation and m6A, identifying critical pseudogenes involved in HGSOC progression. …”
Get full text

FNDC5 and ACOX1 as Biomarkers of Peroxisomal Activity with Contrast Outcomes in Colon Adenocarcinoma by Yuan Hepei, Zeng Jun, Khan Muhammad, Wang Baiyao, Hu Xiaoshan, Wei Hao, Wang Zhaotong, Yuan Yawei

“…Results A seven-gene PRG risk signature was constructed, including four risk-associated genes: ABCD1 (ATP Binding Cassette Subfamily D Member 1), FNDC5 (Fibronectin Type III Domain Containing 5), HAO2 (Hydroxyacid Oxidase 2), and PEX5L (Peroxisomal Biogenesis Factor 5 Like), as well as three protective genes: ABCD3 (ATP Binding Cassette Subfamily D Member 3), ACOX1 (Acyl-CoA Oxidase 1), and NOS2 (Nitric Oxide Synthase 2). …”
Get full text

The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable ion channel by Hongjiang Wu, Liang Sun, Tong Huo, Theodore G. Wensel, Frank T. Horrigan, Zhao Wang

Get full text

Residue-Specific Epitope Mapping of the PD-1/Nivolumab Interaction Using X-ray Footprinting Mass Spectrometry by Line G. Kristensen, Sayan Gupta, Yan Chen, Christopher J. Petzold, Corie Y. Ralston

Get full text

EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells by Fang Xue, Tian‐Feng Sun

Get full text

LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling by Alan Kavšek, Jérôme Salignon, Lluís Millan-Ariño, Patryk Marcinkowski, Ilke Sen, Christian G. Riedel

Get full text

Structural information in therapeutic peptides: Emerging applications in biomedicine by Valentín Iglesias, Oriol Bárcenas, Carlos Pintado‐Grima, Michał Burdukiewicz, Salvador Ventura

“…This review will explore different therapeutic and biotechnological applications of peptides and their assemblies, emphasizing the importance of integrating structural information to advance these endeavors effectively.…”
Get full text

PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes by Li Fang, Man Zhang, Yanhui Li, Yan Liu, Qinghua Cui, Nanping Wang

“…In addition, we developed a machine learning method to predict novel PPAR target genes by integrating in silico PPAR-responsive element (PPRE) analysis with high throughput gene expression data. …”
Get full text

3D concrete printing of topological interlocking blocks by Tom Goertzen, Tobias Neef, Philipp Scheffler, Domen Macek, Viktor Mechtcherine, Alice C. Niemeyer

“…The findings underscore the feasibility of integrating TIA with 3D concrete printing, highlighting potential applications in sustainable construction.…”
Get full text

A Dataset Curated for the Assessment of G4s in the LncRNAs Dysregulated in Various Human Cancers by Shubham Sharma, Muhammad Yusuf Hassan, Noman Hanif Barbhuiya, Ramolia Harshit Mansukhbhai, Chinmayee Shukla, Deepshikha Singh, Bhaskar Datta

“…In this work, we have formulated a comprehensive dataset integrating experimentally-validated associations between lncRNAs and cancer, and detailed predictions of their G4-forming potential. …”
Get full text

Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers by Victor W. Sadongo, Eojin Kim, Seoyoon Kim, W. C. Bhashini Wijesinghe, Taeseung Lee, Jeong-Mo Choi, Duyoung Min

“…Furthermore, our platform allows for the targeted analysis of localized perturbations—such as those induced by peptide binding or site-directed mutagenesis—demonstrating its utility for probing the mechanisms of TM dimer-targeting therapeutics at single-molecule resolution.…”
Get full text

The Multifaceted Role of Calcium Signaling in Regulated Necrosis by Eric Perez-Rivera, Claudia Plasencia, Uris Ros

“…The complexity of calcium signaling is orchestrated by specialized channels in various cellular compartments and calcium-binding proteins that respond to localized calcium concentrations. …”
Get full text

Exploring 5,7-dimethoxyflavone from Piper ornatum as a novel anti-breast cancer candidate: insights from in silico analysis by A. U. Rohmatika, T. Demircan, A. K. M. Jamil, F. R. P. Dewi

“…Molecular docking results showed that 5,7-DMF has a high binding affinity towards the COX-2 target and inhibits kinase activity. …”
Get full text

Free to err? Conceptualising personal autonomy in the postpandemic welfare state by Marc Sørensen, Ezio Di Nucci, Karsten Juhl Jørgensen, Gorm Greisen

“…Based on the example of vaccine hesitancy during COVID-19, we propose that resolving these conflicts should integrate two divergent basic tenets of autonomy, as developed over time, and recently applied disjunctively to the pandemic by ethicists, so that the principle can be consistently operationalised as a function of an open but also binding argument within society. …”
Get full text

Collagen Scaffolds in Bone Sialoprotein-Mediated Bone Regeneration by Thomas E. Kruger, Andrew H. Miller, Jinxi Wang

“…BSP also mediates mineral deposition, binds type I collagen with high affinity, and binds αvβ3 and αvβ5 integrins which mediate cell signaling. …”
Get full text

MiRNAs in Gestational Diabetes Mellitus: Potential Mechanisms and Clinical Applications by Zhao-Nan Liu, Ying Jiang, Xuan-Qi Liu, Meng-Meng Yang, Cheng Chen, Bai-Hui Zhao, He-Feng Huang, Qiong Luo

“…In this review, we summarized an integrated expressional profile and the pathophysiological significance of placental exosomes and associated miRNAs, as well as other plasma miRNAs such as exo-AT. …”
Get full text

TO THE TOPIC ON THE CONTRIBUTION OF INTERNATIONAL ORGANIZATIONS TO THE PRESERVATION OF THE BIO-RESOURCES STOCKS OF THE CASPIAN SEA by R. T. Asanov, E. A. Barskova, V. N. Pal'tsev, S. V. Shipulin

“…It is noted the leading input of specialized state departments, institutes and organizations to the protection, reproduction, researching of water bio-resources and their inhabitant, the results of which were integrated in the frames of work of the Commission on water bio-resources of the Caspian Sea.Main conclusions. …”
Get full text

State accountability in maritime SAR operations involving smuggled migrants: human rights challenges at sea by Md Syful Islam, Dogara Waziri Fadason, Ali Ashraf

“…It proposes concrete legal and institutional reforms, such as binding definitions of “place of safety,” integrated SAR–asylum protocols, and regional disembarkation agreements. …”
Get full text

Sulfated dietary fiber protects gut microbiota from antibiotics by Fuqing Wu, Xiaoqian Annie Yu, David Angeles-Albores, Susan E. Erdman, Eric J. Alm

“…This protective effect is dependent on the structural integrity, molecular weight, and sulfur content of the polysaccharide. …”
Get full text

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems by Budi Mulyanti, Harbi Setyo Nugroho, Chandra Wulandari, Yuni Rahmawati, Lilik Hasanah, Ida Hamidah, Roer Eka Pawinanto, Burhanuddin Yeop Majlis

“…SPR-based technology has emerged as one of the most versatile optical tools for analyzing the binding mechanism of molecular interaction due to its inherent advantages in sensing applications, such as real-time, label-free, and high sensitivity characteristics. …”
Get full text