Identification of novel components of the retinal determination gene network in Drosophila cell lines by Robert A. Drewell, Jacqueline M. Dresch

“…We confirm the regulatory potential for a subset of the novel transcription factors through the identification of predicted binding sites in previously characterized enhancers for the core genes in the network.…”
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Discovering nuclear models from symbolic machine learning by Jose M. Munoz, Silviu M. Udrescu, Ronald F. Garcia Ruiz

“…As a proof of principle, we applied this method to describe the nuclear binding energies and charge radii of light and medium mass nuclei. …”
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Sensitization to Cockroach Allergen: Immune Regulation and Genetic Determinants by Peisong Gao

“…Cockroach-derived protease can disturb airway epithelial integrity via PAR-2 and leads to an increased penetration of cockroach allergen, resulting in activation of innate immune cells (e.g., DCs) via binding to either TLRs or CLRs. …”
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COVID-19 Pandemic and Irritable Bowel Syndrome — is there a Relationship? by V. A. Akhmedov

“…These factors dictate the need for an integrated approach in the management of such a group of patients with the use of modern multi-target drugs that affect the pathogenetic factors in the formation of functional gastrointestinal diseases, one of which is the Kolofort drug due to the triple multi-target mechanism of action on the pathogenesis of functional gastrointestinal diseases.…”
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Multi-Target Synergy Against Acute Lung Injury: Systems Pharmacology Decoding Dahuang-Huangqin Herb Pair’s Therapeutic Mechanism by Zhang J, Zhu X, Chen X, Liu H, Yan Z, Chen Z, Li Q, Yu W

“…Molecular docking revealed strong compound-target binding affinities (energies: − 8.8 to − 7.3 kcal/mol), with emodin and baicalin showing the highest stability. …”
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Automated Microfluidic Platform for High‐Throughput Biosensor Development by Shitanshu Devrani, Daniel Tietze, Alesia A. Tietze

“…Abstract Biorecognition elements immobilized into nanopores have transformed point‐of‐care (POC) diagnostics by converting molecular interactions into electrical and fluorescent signals.This study introduces Bio‐Sensei, a high‐throughput screening (HTS) microfluidic platform based on nanopore biosensing. Integrating a robotic sampler, electrochemical, and fluorescence setup, Bio‐Sensei operates as an Internet of Things (IoT) platform with integrated data analysis. …”
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Regulating unmanned aircraft systems in Antarctica: challenges and collaborative solutions by Yitong Chen, Shu Wu

“…A comprehensive legally binding Measure or at least a resolution adopted by ATCM may be good start for this integrated regulatory process.…”
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Fecal Microbiota and Associated Metabolites Are Minimally Affected by Ten Weeks of Resistance Training in Younger and Older Adults by Anthony Agyin-Birikorang, Sarah Lennon, Kristen S. Smith, William Van Der Pol, Morgan A. Smith, Casey L. Sexton, Donald A. Lamb, Kaelin C. Young, Christopher Brooks Mobley, Kevin W. Huggins, Michael D. Roberts, Andrew Dandridge Frugé

“…These results highlight that 10 weeks of RT largely does not affect fecal microbiota, associated SCFAs, or select markers of gastrointestinal integrity in untrained younger or older adults.…”
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Pharmacological potential of 6,11-dihydro[1,2,4]triazolo[4’,3’:1,6]-pyrido[3,4-b]-5-carboxylic acid and its esters by S. O. Fedotov, A. S. Hotsulia

“…The molecular docking method, based on computational algorithms, has been used to predict and study interactions, including the identification of potential binding sites, estimation of energy parameters and spatial configuration of molecules. …”
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The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces by Yasumasa Iwatani, Kazuhiro Matsuoka, Hirotaka Ode, Mai Kubota, Yoshihiro Nakata, Yuka Setoyama, Kanako Kojima, Mayumi Imahashi, Yoshiyuki Yokomaku

“…In the Vif structure, PPLP-α6 is positioned behind α1-α2 that constitutes the A3-binding Vif interfaces. Therefore, both the PPLP motif and α6 play critical allosteric roles in maintaining the integrity of the A3 interaction interfaces. …”
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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

“…Abstract Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. …”
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The use of CytoSorb® in a prasugrel‐loaded patient undergoing emergent coronary artery bypass graft surgery by Erich Moresco, Hannes Dejaco, Volker Humbert, Matthias Thoma

“…Abstract Patients with acute coronary syndrome (ACS), failed percutaneous coronary intervention (PCI) and with an indication for emergent coronary artery bypass graft surgery (CABG) are at an increased risk of perioperative bleeding. Integration of the CytoSorb® (CS) adsorber into the cardiopulmonary bypass appears to bind prasugrel and minimize the risk of perioperative bleeding.…”
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EvoNB: A protein language model-based workflow for nanobody mutation prediction and optimization by Danyang Xiong, Yongfan Ming, Yuting Li, Shuhan Li, Kexin Chen, Jinfeng Liu, Lili Duan, Honglin Li, Min Li, Xiao He

“…MD simulations analyzed the energy changes caused by these mutations to predict their impact on binding affinity to the targets. The results showed that multiple mutations screened by EvoNB significantly enhanced the binding affinity between nanobody and its target, further validating the potential of this workflow for designing and optimizing nanobody mutations. …”
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Tuning antibody stability and function by rational designs of framework mutations by Joseph C. F. Ng, Alicia Chenoweth, Maria Laura De Sciscio, Melanie Grandits, Anthony Cheung, Tooki Chu, Alexandra McCraw, Jitesh Chauhan, Yi Liu, Dongjun Guo, Semil Patel, Alice Kosmider, Daniela Iancu, Sophia N. Karagiannis, Franca Fraternali

“…This highlighted the effects of FW on immunological functions engendered in distal areas of the antibody, and the importance of considering attributes other than binding affinity when assessing antibody function. …”
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Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors by Adrien Schahl, Louis Lagardère, Brandon Walker, Pengyu Ren, Hugo Wioland, Maya Ballet, Antoine Jégou, Matthieu Chavent, Jean-Philip Piquemal

“…Together, our findings reveal how H73 methylation regulates β-actin plasticity and integrates environmental cues.…”
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Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment by Máté Kiss, Laszlo Halasz, Eva Hadadi, Wilhelm K. Berger, Petros Tzerpos, Szilard Poliska, Daliya Kancheva, Aurélie Gabriel, Romina Mora Barthelmess, Ayla Debraekeleer, Jan Brughmans, Yvon Elkrim, Liesbet Martens, Yvan Saeys, Bence Daniel, Zsolt Czimmerer, Damya Laoui, Laszlo Nagy, Jo A. Van Ginderachter

“…Epigenomic features, such as post-translational modification of histones and chromatin accessibility, are key determinants of transcription factor binding and thereby play an important role in controlling transcriptional responses to the tissue environment. …”
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Microdomain forming proteins in oncogenesis by I. B. Zborovskaya, S. A. Galetskiy, A. V. Komel’kov

“…Involvement of the different lipid rafts is necessary in many situations such as binding of growth factors with their receptors, integrin regulation, cytoskeleton and extracellular matrix rearrangements, vesicular transport, etc. …”
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Germline loss-of-function variant in the E3 ubiquitin ligase TRAF2 in a young adult patient with medulloblastoma: a case report by Josh N. Vo, Andrea Franson, Sebastian M. Waszak, Yi-Mi Wu, Nicole Becker, Arul M. Chinnaiyan, Dan R. Robinson

“…Integrative genomics revealed a biallelic loss of TRAF2 via partial copy-neutral loss-of-heterozygosity of 9q in the medulloblastoma genome. …”
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Nanobodies and their derivatives: pioneering the future of cancer immunotherapy by Haixia Li, Quan Zhou, Nan Cao, Chenghao Hu, Jincheng Wang, Yu He, Shan Jiang, Qi Li, Miao Chen, Li Gong, Ming Luo, Xinzhou Deng, Zhiguo Luo

“…Through their unique capacity to integrate innovative molecular engineering with translational clinical development, nanobody-based therapeutics are poised to revolutionize current paradigms in cancer immunotherapy. …”
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DFT-MD simulations and experimental validation of graphene-CO₂ interaction energies and structural dynamics for enhanced CO₂ adsorption by Atti Srinivas, Ankit Dash, Sarat Chandra Babu Jakka

“…Simulations assumed complete surface accessibility of graphene for CO₂ binding, while experimental setups revealed an actual surface coverage of approximately 50 %-80 % due to constraints in coating homogeneity. …”
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