Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization by Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li

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A large C-terminal Rad52 segment acts as a chaperone to Form and Stabilize Rad51 Filaments by Emilie Ma, Fadma Lakhal, Eleni Litsardaki, Myriam Ruault, Maxime Audin, Natacha Levrier, Emilie Navarro, Mickaël Garnier, Laurent Maloisel, Jordane Depagne, Clémentine Brocas, Aurelien Thureau, Didier Busso, Xavier Veaute, Raphaël Guerois, Angela Taddei, Françoise Ochsenbein, Eric Coïc

“…The molecular basis of these two Rad52 functions remains unclear. Our integrative structural analyses of the Rad51-Rad52 interaction, combining NMR, SAXS, and modeling, reveal that an 85-residue segment of Rad52, conserved in fungi, folds upon binding to a broad surface of a Rad51 monomer. …”
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The Molecular Mechanism of Interaction Between SEPALLATA3 and APETALA1 in Arabidopsis thaliana by Xiao‐Min Tan, Ya‐Ru Li, Man‐Ru Song, Ling‐Na Yuan, Zi‐Xin Zhao, Ye Liu, Qi Meng, Xuan Huang, Ye‐Ye Ma, Zi‐Qin Xu

“…In Arabidopsis, SEP3 functions as a central integrator, combining MADS proteins into a tetrameric complex, with its interaction with AP1 playing a key role in sepal and petal formation. …”
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Transcriptional regulatory network reveals key transcription factors for regulating agronomic traits in soybean by Wu Jiao, Mangmang Wang, Yijian Guan, Wei Guo, Chang Zhang, Yuanchun Wei, Zhenwei Zhao, Hongyu Ma, Longfei Wang, Xinyu Jiang, Wenxue Ye, Dong Cao, Qingxin Song

“…Abstract Background Transcription factors (TFs) bind regulatory genomic regions to orchestrate spatio-temporal expression of target genes. …”
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Retrotransposon life cycle and its impacts on cellular responses by Ahmad Luqman-Fatah, Kei Nishimori, Shota Amano, Yukiko Fumoto, Tomoichiro Miyoshi

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Epidermal Growth Factor and Intestinal Barrier Function by Xiaopeng Tang, Hu Liu, Shufen Yang, Zuohua Li, Jinfeng Zhong, Rejun Fang

“…In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was essential for the absorption of nutrients and health in humans and animals. …”
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The <i>Cordyceps</i> Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach by Jose Luis Gonzalez-Llerena, Daniela Treviño-Almaguer, Jesus Alejandro Leal-Mendez, Gael Garcia-Valdez, Arely Guadalupe Balderas-Moreno, Michel Stéphane Heya, Isaias Balderas-Renteria, María del Rayo Camacho-Corona, Bryan Alejandro Espinosa-Rodriguez

“…Molecular docking simulations were conducted to assess binding affinities of metabolites to key oncogenic targets, and SwissADME was utilized for pharmacokinetic profiling. …”
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From Target Prediction to Mechanistic Insights: Revealing Air Pollution-Driven Mechanisms in Endometrial Cancer via Interpretable Machine Learning and Molecular Docking by Hongyao Liu, Yueqing Zou

“…Molecular docking reveals strong binding between pollutants (e.g., benzene, toluene, and ethylbenzene) and key APECGs. …”
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Potential shared neoantigens from pan-cancer transcript isoforms by Jirapat Techachakrit, Aijaz Ahmad Malik, Trairak Pisitkun, Sira Sriswasdi

“…The presence of neoantigen-containing peptides derived from these transcripts was confirmed in broad cancer and normal tissue proteome datasets and the binding affinity of predicted neoantigens to the human leukocyte antigen (HLA) complex via molecular dynamics simulations. …”
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The Legal Imperative of Bawaslu's Oversight in Enforcing Verdict Compliance by Pebby Pratiwi Nadeak, Sultoni Fikri, Imranullah Akhtar

“…As a quasi-judicial institution, Bawaslu has the authority to issue decisions that are final and binding. However, in practice, the implementation of follow-up to Bawaslu decisions often faces challenges, such as disobedience or suboptimal implementation by the KPU and related parties. …”
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Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development by Yuan‐Tao Liu, Le‐Le Zhang, Zi‐Ying Jiang, Xian‐Shu Tian, Peng‐Lin Li, Pei‐Huang Wu, Wen‐Ting Du, Bo‐Yu Yuan, Chu Xie, Guo‐Long Bu, Lan‐Yi Zhong, Yan‐Lin Yang, Ting Li, Mu‐Sheng Zeng, Cong Sun

“…We further discuss the integration of high‐throughput experimentation, closed‐loop validation, and AI‐guided optimization in expanding the druggable proteome and enabling precision medicine. …”
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Deep neural network-based probabilistic classifier of occupational accident types on a construction site in Korea by Taehoon Kim, Myungdo Lee, Yoonseok Shin, Wi Sung Yoo

“…The number of accidents in the Korean construction industry has been increasing rapidly, reaching about 25,000 every year. Although strong and binding laws and systems have been implemented to reduce accidents in the construction industry, the frequency of accidents is still higher than that of other industries. …”
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Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos by Huihan Bao, Shihe Zhang, Zhiyang Yu, Heng Xu

“…Applying this approach to quantitative imaging of fixed wild-type embryos, we resolve the spatiotemporal regulation of the endogenous segmentation gene Krüppel (Kr) by multiple transcription factors (TFs) during early development without genetic modification. Integrating a time-resolved theoretical model of single-molecule mRNA statistics, we further uncover the unsteady-state bursty kinetics of the endogenous segmentation gene, hunchback (hb), driven by dynamic TF binding. …”
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MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters by Xin-Yan Lu, Hongxu Jin

“…Ultimately, this review underscores the significance of integrating miRNA research into existing therapeutic frameworks to enhance the efficacy of doxorubicin in cancer treatment.…”
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“If you want to become God, free yourself”: Construction of the bourgeois ethic by German folk preachers in the first half of the 14th century by M. Yu. Reutin

“…Without this underpinning, these manifestations remain little more than witty observations and have no binding character.…”
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USP37 protects mammalian cells during DNA replication stress by counteracting CUL2LRR1 and TRAIP by Fabrizio Villa, Johanna Ainsworth, Karim P.M. Labib

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Reforma szlachectwa w Królestwie Polskim w latach 1836-1861 by Tomasz Demidowicz

“…This principle was overtly contrary to the spirit of the Organic Statute of 1832 and infringed the rule of equality before law. undermining at the same time the integrity of the civil and criminal codes binding in the Kingdom of Poland. …”
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Fission yeast Caprin protein is required for efficient heterochromatin establishment. by Haidao Zhang, Ekaterina Kapitonova, Adriana Orrego, Christos Spanos, Joanna Strachan, Elizabeth H Bayne

“…We determine that the previously uncharacterised protein is an ortholog of human Caprin1, an RNA-binding protein linked to stress granule formation. …”
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A minimal model for the mitochondrial rapid mode of Ca²+ uptake mechanism. by Jason N Bazil, Ranjan K Dash

“…The mechanism is based on Ca²⁺ binding to an external trigger site(s) and initiating a brief transient of high Ca²⁺ conductivity. …”
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Widespread cotranslational formation of protein complexes. by Caia D S Duncan, Juan Mata

“…In a sample of 31 proteins from Schizosaccharomyces pombe that did not contain RNA-binding domains, we found that ∼38% copurify with mRNAs that encode interacting proteins. …”
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