Development of Soy-Based Meat Analogues via Wet Twin-Screw Extrusion: Enhancing Textural and Structural Properties Through Whole Yeast Powder Supplementation by Shikang Tang, Yidian Li, Xuejiao Wang, Linyan Zhou, Zhijia Liu, Lianzhou Jiang, Chaofan Guo, Junjie Yi

“…Although lower in protein content than yeast protein powder (YPP), whole yeast powder exhibits superior water-binding capacity and network-forming ability owing to its complex matrix and fiber content. …”
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A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics by Wafa Tombari, Oussema Khamessi, Houcemeddine Othman, Ouafa Kallala, Rihab Mahjoub, Kais Ghedira, Abdelhalim Trabelsi

“…The selected epitopes exhibited strong binding affinity to high-frequency HLA alleles, as evidenced by highly negative ΔG values and low dissociation constants, predicting efficient T-cell recognition and broad population coverage (96.01% globally). …”
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In Silico Design and Characterization of a Multiepitope Vaccine Candidate Against Brucella canis Using a Reverse Vaccinology Approach by Vicente Arriagada, Alberto Osorio, Crisleri Carrera-Naipil, Carlos A. Villacis-Aguirre, Cristian Escobar, Nicolás Morales, Danthe Villa, Lien Mardones, Dafne Pérez, Macarena Jara, Raúl E. Molina, Ítalo Ferrari, Sebastián Azocar, Leonardo A. Gómez, Ángel A. Oñate

“…Validation of its secondary and tertiary structures, along with molecular docking analysis, revealed a high binding affinity to the TLR4 receptor. Molecular dynamics simulations and normal mode analysis further confirmed the vaccine’s structural stability and binding capacity. …”
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Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation by Liu P, Zeng L, Fu H, Li F

“…Subsequently, molecular docking confirmed the binding capacity of these bioactive ingredients to pivotal targets. …”
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ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy by Christoph Huber, Christian Stocker, Patrizia Murer, Ulisse Salazar, Nicole Egli, Laetitia Petersen, Pia Neubert, Alexander Rau, Andreas Katopodis, Anais Zurbach, Dario Reichenstein

“…This design allows for selective expansion of tumor antigen-specific T cells while avoiding the systemic toxicity and regulatory T cell (Treg) expansion associated with conventional IL-2 therapies.Methods The PD-1-targeting antibody used in ANV600 was generated by immunization of humanized mice and selected for its ability to bind PD-1 without blocking the binding epitope of PD-1 checkpoint blocking agents. …”
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Chemosensitization and Molecular Docking Assessment of Dio-NPs on Resistant Breast Cancer Cells to Tamoxifen by Amr A. Abd-Elghany, Ebtesam A. Mohamad, Abdullah Alqarni, Mohammed A. Hussein, Mohamed S. Mansour

“…The simulations revealed that diosgenin effectively binds to CDK4, AKT, and CDK6, maintaining their stability and structural integrity. …”
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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate by Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo

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Unraveling SREBF1's role in elevating colorectal cancer prognosis through proliferation and migration inhibition. by Dongling Li, Qinrui Cai, Fan Xu, Ling Lin, Xiaoya Zhou, Li Li, Yao Chen, Tianlin Feng, Yuanxiu Gan, Chenhua Zhang, Fan Yang

“…Sterol Regulatory Element-Binding Protein 1 (SREBF1), a central regulator of lipid metabolism, has unclear pan-cancer roles and clinical implications. …”
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Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

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Radiation Synovectomy: An Enticing Treatment Option for Inflammatory Joint Pain by Ashutosh Dash, Tapas Das

“…The selection of an optimal radionuclide hinges on critical nuclear and chemical properties, ensuring effective binding to microparticles and delivering favorable clinical outcomes. …”
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LABOR PROTECTION IN THE PERIOD OF DEVELOPMENT OF INNOVATIVE ECONOMY by Yu. V. Baranov

“…Taking into account that the working person is a source of innovation in production improvement, it could be proposed to create safe and healthy working conditions for the realization of creative ideas, and this research is considered the integral part of innovative activity.…”
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Breaking barriers in antibody discovery: harnessing divergent species for accessing difficult and conserved drug targets by Soma S.R. Banik, Natasha Kushnir, Benjamin J. Doranz, Ross Chambers

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Accountability of Temporary Land Deed Official Not Included as Defendants in Deed Revocation Rulings by Nilna Firkhana Soraya, Sukarmi, Patricia Audrey Ruslijanto

“…Nevertheless, the judge ruled that the Grant Deed was legally defective, lacked binding legal force, and was declared null and void by operation of law. …”
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Information Security Evaluation at Hospital Using Index KAMI 5.0 and Recommendations Based on ISO/IEC 27001:2022 by I Nyoman Adi Artha Wibawa, Anak Agung Ngurah Hary Susila, Muhammad Alam Pasirulloh

“…Bali Mandara Regional Hospital integrates information technology into its healthcare services, but ransomware attacks pose significant risks to data security. …”
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Multi-Target Mechanism of Compound Qingdai Capsule for Treatment of Psoriasis: Multi-Omics Analysis and Experimental Verification by Qiao Y, Li C, Chen C, Wu P, Yang Y, Xie M, Liu N, Gu J

“…Molecular docking confirmed good binding affinity between these targets and ingredients. …”
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Network pharmacology and experimental study of Angelica sinensis and Astragalus membranaceus capsules in treating heart failure by Xue Wu, Ai Liu, Xinfang Lv, Xiaodong Zhi, Xiangting Zeng, Kai Liu, Xinke Zhao, Bing Jiang, HuGang Jiang, Yingdong Li

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Reversible ubiquitination conferred by domain shuffling controls paired NLR immune receptor complex homeostasis in plant immunity by Zhiyi Chen, Jianhua Huang, Jianyu Li, Frank L. H. Menke, Jonathan D. G. Jones, Hailong Guo

“…Phylogenetic analysis suggests this regulation likely transferred from WRKY70/WRKY41 to RRS1 upon WRKY domain integration. Our findings improve our understanding of homeostatic regulation of paired NLR complex and uncover a paradigm whereby domain integration can co-opt preexisting post-translational modification to regulate novel protein functions.…”
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A blockchain-based verifiable CP-ABE scheme for medical data privacy protection by Leilei Zhao, Guofang Dong, Hao Yuan

“…Meanwhile, the integrated Attribute-Based Proxy Re-Encryption (AB-PRE) supports dynamic and efficient adjustment of access rights based on patient status and treatment needs. …”
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Machine learning and molecular docking prediction of potential inhibitors against dengue virus by George Hanson, Joseph Adams, Daveson I. B. Kepgang, Luke S. Zondagh, Lewis Tem Bueh, Andy Asante, Soham A. Shirolkar, Maureen Kisaakye, Hem Bondarwad, Olaitan I. Awe

“…ZINC95485940, ZINC38628344, 2′,4′-dihydroxychalcone and ZINC14441502 demonstrated a high binding affinity of −8.1, −8.5, −8.6, and −8.0 kcal/mol, respectively, exhibiting stable interactions with His51, Ser135, Leu128, Pro132, Ser131, Tyr161, and Asp75 within the active site, which are critical residues involved in inhibition. …”
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Extracellular ligand-responsive translational regulation of synthetic mRNAs using engineered receptors by Hideyuki Nakanishi, Keiji Itaka

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