H/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation by Paulina Fischer, Matthias Thoms, Benjamin Lau, Timo Denk, Maria Kuvshinova, Otto Berninghausen, Dirk Flemming, Ed Hurt, Roland Beckmann

“…Integration into the 90S is blocked by RNA hybridization with snR30. …”
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Aptamer-engaged nanotherapeutics against SARS-CoV-2 by Jing Zhang, Dan Wang, Chiu Kwok, Liujun Xu, Michalina Famulok

“…The integration of aptamers with nucleic acid nanomedicine is explored. …”
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FILAMIN A IN BREAST CANCER: FROM LITERATURE TO FUNCTIONAL INSIGHTS

“…Filamin A (FLNa), an actin binding protein, has been implicated in processes such as cell migration, adhesion, proliferation, and DNA repair. …”
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Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis. by Yue Chen, Berge Hagopian, Shumin Tan

“…Potassium (K+) is the most abundant intracellular cation, but much remains unknown regarding how K+ homeostasis is integrated with other key bacterial biology aspects. …”
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The biophysical basis underlying the maintenance of early phase long-term potentiation. by Moritz F P Becker, Christian Tetzlaff

“…We test this hypothesis by formalizing a biophysical model that integrates several experimentally-motivated mechanisms. …”
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An automated interface for sedimentation velocity analysis in SEDFIT. by Peter Schuck, Samuel C To, Huaying Zhao

“…The interface can be integrated in custom GMP compatible software, and in scripts that provide documentation and meta-analyses for replicate or related samples, for example, to streamline analysis of large families of experimental data, such as binding isotherm analyses in the study of protein interactions. …”
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DHX15 inhibits mouse APOBEC3 deamination. by Wenming Zhao, Ayan Modak, Susan R Ross

“…Finally, DHX15 knockdown induced DNA damage in murine cells, suggesting that it plays a role in preserving genome integrity in cells expressing mouse APOBEC3 protein.…”
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Functional omics of ORP7 in primary endothelial cells by Juuso H. Taskinen, Minna Holopainen, Hanna Ruhanen, Miesje van der Stoel, Reijo Käkelä, Elina Ikonen, Salla Keskitalo, Markku Varjosalo, Vesa M. Olkkonen

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Realization of a three-dimensional photonic higher-order topological insulator by Ziyao Wang, Yan Meng, Bei Yan, Dong Zhao, Linyun Yang, Jingming Chen, Minqi Cheng, Tao Xiao, Perry Ping Shum, Gui-Geng Liu, Yihao Yang, Hongsheng Chen, Xiang Xi, Zhen-Xiao Zhu, Biye Xie, Zhen Gao

“…Here, we present the experimental realization of a 3D Wannier-type photonic HOTI using a tight-binding-like metal-cage photonic crystal, whose band structures align with a 3D tight-binding model via confined Mie resonances. …”
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A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome by France Côté, Elizabeth Prairie, Estefania Marin Sierra, Christiane Quiniou, Tiffany Habelrih, Wendy Xu, Béatrice Ferri, Xin Hou, Isabelle Lahaie, Nadia Côté, Sarah-Eve Loiselle, Laurence Gobeil, Kevin Sawaya, Aurélie Faucher, Amélie Beaulieu, Sandrine Delisle, Marie-Pénélope Simard, Mohammad Ali Mohammad Nezhady, Véronique Laplante, Allan Reuben, Sidi Mohamed Kalaidji, Emmanuel Bajon, Gael Cagnone, Kelycia B Leimert, Jean-François Gauchat, Luc Gaudreau, Sarah Robertson, William D Lubell, David M Olson, Sylvain Chemtob

“…Our group developed a small peptide, HSJ633, that antagonizes the interleukin-6 receptor (IL-6R). Binding assays performed on HEK-Blue IL-6 cells reveal that HSJ633 appears to bind to IL-6R on a site remote from the IL-6 binding domain. …”
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Targeting metzincins to mitigate jellyfish blooms: a novel approach for conservation by Xuecun Liu, Xuecun Liu, Xiao Peng, Jingqiang Wang, Shuhui Ju, Qing Sun, Wensai Ji, Xiaoyu Hua, Haiyan Zhang, Juan Höfer, Marina Pozzolini, Shuogui Xu, Xueqi Ma, Liang Xiao

“…EDTA was capable of stably binding to the zinc-binding active sites of the four major types of metzincins in the A. coerulea polyp and could down-regulate the expression levels of key metzincin molecules and enrich multiple pathways related to development.ConclusionThis study elucidates the effects of metzincins on the budding of jellyfish polyps, providing a potential target for mitigating jellyfish blooms.…”
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NOD1 and NOD2: intracellular pattern recognition receptors implicated in gynaecological malignancies and their therapeutic potential by Yuanyuan Zhang, Duan Yang, Xinlu Liu

“…Nucleotide-binding oligomerisation domains (NODs) are pattern recognition receptors involved in the detection of intracellular pathogenic microorganisms and important members of the NOD-like receptor family. …”
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Analyzing the Nature of Apparent Authority in Islamic Jurisprudence and Iranian Law by Hamid Reza Habibi, Behzad Pourseyyed

“…Conclusiveness: The assumption is binding and provides finality for third-party transactions.     …”
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Multifactor clinical-laboratory valuation of endogenic intoxication in chronic hepatitis B by N. I. Khokhlova, N. P. Tolokonskaya, A. B. Pupyshev

“…For the determining of the role of clinical data and integral laboratory indices in the valuation of endogenic intoxication (EI) in chronic hepatitis B (HHB) 100 patients and 20 healthy adults were examined. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…Comprehensive RNA‐seq, integrated single‐cell mapping and further experiments unveiled the involvement of MAPK6 in inflammation through the EGR1/CXCL12 axis. …”
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Targeting B-raf/MEK signaling in melanocytic carcinoma using HPLC-MS/MS characterized metabolites from Valeriana wallichii Rhizome by Charushila V. Balikai, Raviraj M. Kulkarni, Kiran Thabaj, Shankar Gharge, Rohini S. Kavalapure, Shyam S. Desai

“…This study explores its therapeutic potential against A375 human melanoma cells through an integrated in silico, in vitro pharmacological approach. …”
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Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach by Mohd Imran, Ahmed S. Alshrari, Mariah N. Hafiz, Mohammed M. Jawad, Abida Khan, Fadiyah Jadid Alanazi, Syed Mohammed Basheeruddin Asdaq

“…MD simulations confirmed binding stability with RMSD fluctuations within 2.1–3.5 Å and MM-GBSA energy values supporting ligand-protein stability. …”
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Glycosyl Mobile Radical Structures of Folic Acid Receptors Impact the Internalization of Functionalized Folate Amphiphilic Alternating Copolymer in Cancer Cells by Emilyn B. Aucoin, Elizabeth Skapinker, Abdulrahman M. Yaish, Yunfan Li, Haley L. Kombargi, Daniel Jeyaraj, Pankaj Garg, Nicole Mendonza, Cecile Malardier-Jugroot, Myron R. Szewczuk

“…These glycosylation sites have been reported to be crucial for the receptor’s structural integrity and its ability to bind and internalize FA. …”
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Role of the Annexin A protein family in liver diseases: insights and therapeutic opportunities by Mingyang Feng, Yong He, Hui Wang

“…The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca2+)- and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. …”
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From Physicochemical Classification to Multidimensional Insights: A Comprehensive Review of Uremic Toxin Research by Mario Cozzolino, Lorenza Magagnoli, Paola Ciceri

“…In this review, we systematically examined the evolution of UT classification from the 2003 European Uremic Toxin Work Group (EUTox) system based on molecular weight and protein-binding properties to the 2023 multidimensional framework integrating clinical outcomes, clearance technologies, and artificial intelligence. …”
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