m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells by Qian Zhou, Xianyang Liu, Huiping Lu, Na Li, Jiayu Meng, Jiaxing Huang, Zhi Zhang, Jiangyi Liu, Wei Fan, Wanqian Li, Xingran Li, Xiaoyan Liu, Hangjia Zuo, Peizeng Yang, Shengping Hou

“…Furthermore, through the integration of Methylated RNA immunoprecipitation (MeRIP) sequencing and RNA sequencing, we discovered that the metabolic enzyme quinolinate phosphoribosyltransferase (QPRT) was directly modified by METTL3 and recognized by the YTH N6-methyladenosine RNA binding protein C1 (YTHDC1). …”
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Using Image-based AI for insect monitoring and conservation - InsectAI COST Action by Tom August, Mario Balzan, Paul Bodesheim, Gunnar Brehm, Lisette Cantú-Salazar, Sílvia Castro, Joseph Chipperfield, Guillaume Ghisbain, Alba Gomez-Segura, Jérémie Goulnik, Quentin Groom, Laurens Hogeweg, Chantal Huijbers, Andreas Kamilaris, Karolis Kazlauskis, Wouter Koch, Dimitri Korsch, João Loureiro, Youri Martin, Angeliki Martinou, Kent McFarland, Xavier Mestdagh, Denis Michez, Charlie Outhwaite, Luca Pegoraro, Nadja Pernat, Lars Pettersson, Pavel Pipek, Cristina Preda, David Rolnick, Tobias Roth, David Roy, Helen Roy, Veljo Runnel, Martina Sasic, Dmitry Schigel, Julie Sheard, Cecilie Svenningsen, Heliana Teixeira, Nicolas Titeux, Thomas Tscheulin, Elli Tzirkalli, Marijn van der Velde, Roel van Klink, Nicolas Vereecken, Sarah Vray, Toke Thomas Høye

“…Specifically, the EU Nature Restoration Law will likely set binding targets for the high resolution data that cameras can provide. …”
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急性卒中院前诊断识别研究进展(Research Progress in Prehospital Diagnosis and Identification of Acute Stroke) by 王荣，何松，岗瑞娟，王琪，唐宇杰，刘飞凤，杨杰，李刚，林亚鹏(WANG Rong, HE Song, GANG Ruijuan, WANG Qi, TANG Yujie, LIU Feifeng, YANG Jie, LI Gang, LIN Yapeng)

“…Biomarkers (such as glial fibrillary acidic protein and S100 calcium-binding protein B) exhibit significant potential in differentiating stroke subtypes, but their prehospital application remains limited due to complex detection techniques and lack of standardization. …”
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Function of B8N6S4 in Regulating the Growth and Aflatoxin B1 Biosynthesis of Aspergillus flavus by Xinze ZHANG, Ruisi PU, Jinlu NIU, Wenjie HUANG, Shijuan YAN, Wenyang ZHANG, Shaowen WU

“…【Results】Bioinformatics analysis showed that B8N6S4 contained a typical GAL4-like Zn(Ⅱ)2Cys6 DNA-binding domain and a fungal-specific transcription factor domain. …”
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Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer by Chengdi Wang, Jingwei Li, Jingyao Chen, Zhoufeng Wang, Guonian Zhu, Lujia Song, Jiayang Wu, Changshu Li, Rong Qiu, Xuelan Chen, Li Zhang, Weimin Li

“…Furthermore, TP53 missense mutation in DNA-binding domain could contribute to shorter time to recurrence. …”
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Bioactive camel milk peptides as regulators of insulin receptor signaling: Experimental and computational perspectives by Issoufou Katambe Mohamed, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang, Mouhamed Fall

“…Molecular docking, molecular dynamics simulations, and in silico mutagenesis revealed that TYYPPQ binds allosterically to the inactive IR kinase domain, engaging key regulatory residues Glu1047 and Asp1150 within the DFG motif and activation loop. …”
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Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons by KeHuan K. Edmonds, Max E. Wilkinson, Daniel Strebinger, Hongyu Chen, Blake Lash, Clarissa C. Schaefer, Shiyou Zhu, Dangliang Liu, Shai Zilberzwige-Tal, Alim Ladha, Michelle L. Walsh, Chris J. Frangieh, Nicholas A. Vaz Reay, Rhiannon K. Macrae, Xiao Wang, Feng Zhang

“…We further improve the integration efficiency by chemically modifying the 5′ end of the donor RNA and optimizing delivery, creating a compact system that achieves over 80% integration efficiency in several human cell lines. …”
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Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study by Kaifang Yao, Lei Yang, Qiuyu Zhang, Chao Li, Hongjun Tian, Chuanjun Zhuo

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the core targets were performed to identify key biological processes and signaling pathways, and a target-pathway-drug integrated network was established. The binding affinities of amisulpride and aripiprazole with core targets were predicted using molecular docking analyses. …”
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Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing by Yizhen Chen, Meng Cheng, Rong Dai, Weili Wang, Yonghao Sang, Liuting Wei, Yilin Gao, Wei Zhang, Yiping Wang, Lei Zhang

“…Enrichment analysis showed significant pathways including Rap1 signaling, extracellular matrix–receptor interaction, and PI3K-Akt signaling, with RBPs enriched in RNA binding and ferroptosis.Conclusion By integrating data from three distinct models, we identified conserved ceRNA axis—TCONS_00008870/circRNA_3140–miR-466b-3p–Adamts2—potentially modulating fibrotic progression in renal tissue.…”
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Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models by Hongbo Cheng, Yijiao Men, Yaqing An, Jiegang Yu, Gengshen Zhang, Jiaming Li, Xiaoliang Wang, Guozhu Sun, Yang Wu

“…Chip-qPCR was employed to further elucidate the binding sites of the transcription factor c-Jun.ResultsThe expression of S1pr2 significantly increased following TBI in mice. …”
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In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design by Rayhan Chowdhury, Samia Akter Saima, Md. Al Amin, Md. Kawsar Habib, Ramisa Binti Mohiuddin, Ali Mohamod Wasaf Hasan, Roksana Khanam, Shahin Mahmud

“…Molecular docking and MD simulation evaluations highlighted two candidates—Molecule 23 and Molecule 5, demonstrating superior binding affinities to Penicillin-binding protein 1a (PDB ID: 2V2F) compared to controls. …”
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Estimation of Balance Reliability for Deficit Power System by O. I. Alexandrov, N. V. Radoman, T. E. Zhykovskaja

“…The paper presents a method for complex estimation of balance reliability for a deficit power system. An integral estimation is based on a vector function of the total power shortfall. …”
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Investigation of the Anti-Lung Cancer Mechanisms of <i>Taraxacum officinale</i> Based on Network Pharmacology and Multidimensional Experimental Validation by Jianing Liu, Hailing Yang, Ran Liu, Dongjin Sun, Yongbao Liu, Jing Lu, Jinbiao Liu, Junrui Lu

“…Molecular docking results demonstrated stable binding interactions between major active compounds and the identified core targets. …”
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Revealing novel protein interaction partners of glyphosate in Escherichia coli by Alix Sarah Aldehoff, Dominique Türkowsky, Patrick Lohmann, Masun Nabhan Homsi, Ulrike Rolle–Kampczyk, Elke Ueberham, Jörg Lehmann, Martin von Bergen, Nico Jehmlich, Sven–Bastiaan Haange

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Mutagenesis of SlNAC4 by CRISPR/Cas9 alters gene expression and softening of ripening tomato fruit by Ying Gao, Yi-Ping Zhang, Zhong-Qi Fan, Yuan Jing, Jian-Ye Chen, Donald Grierson, Rui Yang, Da-Qi Fu

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Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments by Yi Zhou, Shaoshuo Li, Bowen Hong, Zihan Wang, Yang Shao, Mao Wu, Mao Wu, Jianwei Wang, Jianwei Wang

“…Western blot analysis revealed that Iso treatment targeting the RANKL/RANK binding pathway significantly downregulated phosphorylation levels of JNK, P38, AKT, and p65. …”
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Computational Pharmacology Analysis of Lycopene to Identify Its Targets and Biological Effects in Humans by Abhinand Rao, Arun H. S. Kumar

“…Molecular docking was used to estimate binding affinities, and concentration-affinity (CA) ratios were calculated based on physiologically relevant plasma concentrations (75–210 nM). …”
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Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease by Junshi Zhang, Tingting Liu, Haojie Wu, Jianshe Wei, Qiumin Qu

“…Finally, molecular docking was performed between the anti-PD drugs entering clinical phase IV and the target genes. LRPPRC has low binding energy and strong affinity with duloxetine and donepezil, with binding energies of -7.6 kcal/mol and − 8.7 kcal/mol, respectively. …”
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The potential mechanism of Huangqin for treatment of systemic lupus erythematosus based on network pharmacology, molecular docking and molecular dynamics simulation by Shuting Zheng, Hui Yang, Jialing Wu, Ou Jin, Xi Zhang

“…Results of molecular docking indicated good binding affinity of Huangqin to stigmastero, baicalein and acacetin. …”
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The role of object-based attention in semantic working memory by Ting Guo, Leyue Ye, Jinfeng Huang, Zhihan Xu

“…IntroductionRecent studies suggest that working memory (WM) temporarily stores and processes bindings, while semantically related WM processing interacts with long-term memory (LTM). …”
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