FOLR1-Targeted Oxygen-Delivering Nanosomes Enhance Chemo-Induced Apoptosis in Hypoxic Cancer by Lee G, Kim J, Yang J, Jang Y, Jang J, Tanaka M, Niepa THR, Lee HY, Choi J

“…The nanosomes demonstrated selective binding to FOLR1-expressing tumor cells and sustained release of doxorubicin. …”
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The energy of internal areas: a systemic approach in Taranta Peligna by Rossana Gaddi, Luciana Mastrolonardo

“…If urban centres need integrated responses to today’s polycrisis, in internal territories where the demand is lower and the per-capita hectare is greater, the ecological transition can be triggered at a cultural, environmental and technological level with a climate-positive approach that distributes energy in a collaborative-community way so that the energy contribution is functional to a new socially-based development model. …”
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A Novel Metallo‐β‐Lactamase AMM‐1 From Alteromonas mangrovi Reveals a Cryptic Environmental Reservoir of Carbapenem Resistance by Xuan Wu, Xinjing Han, Lu Zhu, Ningning Pi, Yi Li, Rong Xiang

“…These findings highlight the capacity of environmental microbes to serve as long‐standing, cryptic reservoirs of potent resistance determinants, emphasising the need for integrated environmental surveillance and preemptive stewardship strategies. …”
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Medicinal evaluation and molecular docking study of osajin as an anti-inflammatory, antioxidant, and antiapoptotic agent against sepsis-associated acute kidney injury in rats by Mohammad Alhilal, Huseyin Serkan Erol, Serkan Yildirim, Ahmet Cakir, Murat Koc, Suzan Alhilal, Esra Dereli, Omer Alkanoglu, Volkan Ay, Ismail Can, Mesut Bunyami Halici

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Gene Expression Comparison Between the Injured Tubercule Skin of Turbot (<i>Scophthalmus maximus</i>) and the Scale Skin of Brill (<i>Scophthalmus rhombus</i>) by João Estêvão, Andrés Blanco-Hortas, Juan A. Rubiolo, Óscar Aramburu, Carlos Fernández, Antonio Gómez-Tato, Deborah M. Power, Paulino Martínez

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Effects of protein on green tea quality in a milk-tea model during heat treatment: Antioxidant activity, foaming properties, and unbound small-molecule metabolome by Nan Chen, Zeting Jiao, Ke Xie, Junying Liu, Peng Yao, Yangchao Luo, Tiehua Zhang, Ken Cheng, Changhui Zhao

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Immunoinformatic development of a multiepitope messenger RNA vaccine targeting lipoate protein ligase and dihydrolipoamide dehydrogenase proteins of Mycoplasma bovis in cattle by Dhafer Rasheed Al-Fetly, Dhama Alsallami, Amjed Alsultan

“…The construct demonstrated promising immunogenicity, structural integrity, and receptor-binding properties, representing a viable vaccine strategy. …”
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ER-related E2-E3 ubiquitin enzyme pair regulates ethylene response by modulating the turnover of ethylene receptors by Qingcui Zhao, Xiaofeng Zhou, Qian Chen, Ruoyun Yang, Yonghong Li, Jiaxin Zhao, Xijia Fu, Yan Lin, Yuming Liu, Liangjun Zhao, Cai-Zhong Jiang, Su-Sheng Gan, Qi Xie, Junping Gao, Nan Ma

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Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries by Anastasia A. Kobelyatskaya, Valeria Morgunova, Aleksey Kalinkin, Anna A. Shchukina, Olesya Sokolova, Dmitry A. Kwon, Sergei Funikov, Alla Kalmykova

“…Abstract Background Insulators are the multifunctional DNA binding proteins that perform architectural functions and regulate gene transcription. …”
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Computational analysis of DEHP’s oncogenic role in colorectal cancer by Zhou Zhu, Jian Qin, Chungang He, Shuangyou Wang, Yaolin Lu, Shuai Wang, Xiaogang Zhong

“…Molecular docking experiments demonstrated strong binding affinities of DEHP with BCL2 (− 8.7 kcal/mol), CDK1 (− 7.8 kcal/mol), and CDK4 (− 6.8 kcal/mol). …”
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Trapping and de-trapping behavior of hydrogen isotopes in <100> interstitial dislocation loops of tungsten by Fei Sun, Qihang Liu, Baichuan Xu, Xiao-Chun Li, Jipeng Zhu, Dahuan Zhu, Hai-Shan Zhou, Hongxiang Zong, Lai-Ma Luo, Yasuhisa Oya, Yucheng Wu

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Agreements limiting or expanding grounds for annulling international arbitral awards by Nikolić Dragana

“…Within the traditional framework of international arbitration, an arbitral tribunal produces a final and binding award, which can be only exceptionally annulled based on the narrowly tailored grounds available under the law of the seat. …”
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Calcification of the elastic component: the impact on the cardiovascular system by Francesco Demetrio Lofaro, Alessia Mazzilli, Susanna Bonacorsi, Daniela Quaglino, Federica Boraldi

“…In cardiovascular diseases, for instance, calcification represents an integral part of the pathogenetic process, although the regulatory mechanisms are not completely understood. …”
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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE by Yaqi Liu, Chelsea M. Brown, Nuno Borges, Rodrigo N. Nobre, Satchal Erramilli, Meagan Belcher Dufrisne, Brian Kloss, Sabrina Giacometti, Ana M. Esteves, Cristina G. Timóteo, Piotr Tokarz, Rosemary J. Cater, Todd L. Lowary, Yasu S. Morita, Anthony A. Kossiakoff, Helena Santos, Phillip J. Stansfeld, Rie Nygaard, Filippo Mancia

“…Key residues involved in substrate coordination and catalysis were identified and validated via in vitro assays and in vivo complementation, while molecular dynamics simulations delineated access pathways and binding dynamics. Our integrated approach provides comprehensive insights into PimE function and informs potential strategies for anti-TB therapeutics.…”
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DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model by Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu

“…As a hybrid neural network model combining convolutional neural networks and bidirectional long short-term memory, DeepAptamer integrated sequence composition and structural features to predict aptamer binding affinities and potential binding motifs. …”
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Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM) by Madeline K. Brown, Zhongli Cai, Constantine J. Georgiou, Shaohuang Chen, Yumeela Ganga-Sah, Valery Radchenko, James T. Rutka, Raymond M. Reilly

“…Panitumumab-[197Hg]Hg-AuNPs exhibited high affinity (KD = 1.8 × 10–9 mol/L) binding to EGFR-positive U251-Luc cells. The binding of panitumumab-[197Hg]Hg-AuNPs to U251-Luc cells was 15-fold higher than [197Hg]Hg-AuNPs, and internalization and nuclear uptake were 12-fold and 18-fold greater, respectively. …”
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Correlative 99m Tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of parkinson disease by Ajit Shinto, Joppy Antony, Koramadai Kamaleshwaran, Krishnan Vijayan, Arul Selvan, Aruna Korde, Mythili Kameshwaran, Grace Samuel

“…Specific uptake in the striatum and its sub-regions, including the putamen and caudate nucleus was calculated and the ratios of specific striatal binding to nonspecific occipital binding were calculated. …”
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Variable orthogonality of serine integrase interactions within the ϕC31 family by Alasdair I. MacDonald, Aron Baksh, Alexandria Holland, Heewhan Shin, Phoebe A. Rice, W. Marshall Stark, Femi J. Olorunniji

“…AlphaFold-Multimer predicts very similar structural interactions between each cognate integrase – RDF pair. The binding surface on the RDF is much more conserved than the binding surface on the integrase, an indication that specificity is determined more by the integrase than the RDF. …”
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Prevention of torture of persons deprived of liberty in Serbia: the State of affairs and challenges by Tanjević Nataša

“…This is particularly important if bearing in mind that the right to physical integrity and human dignity falls under the human rights category and that the prohibition of torture has a special status in international law and is treated as an imperative norm, thus, binding every state.…”
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Circular RNA LMBR1 inhibits bladder cancer progression by enhancing expression of the protein ALDH1A3 by Yifan Lv, Zusen Yuan, Dongmao Chen, Zhibin Chen, Xiaowei Zhu, Xiaoling Ying, Yapeng Huang, Weidong Ji, Defeng Qi

“…Background: Circular RNAs (circRNAs) have been identified as playing an integral role in the development of bladder cancer (BC). …”
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