Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease. by Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach

“…We identified seven RNA binding proteins using enhanced CrossLinking and ImmunoPrecipitation precipitation (eCLIP) with one or more binding sites in the SERPINA1 3' UTR. …”
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Copper homeostasis and neurodegenerative diseases by Yuanyuan Wang, Daidi Li, Kaifei Xu, Guoqing Wang, Feng Zhang

“…Emerging evidence suggests that abnormal copper metabolism or copper binding to various proteins, including ceruloplasmin and metallothionein, is involved in the pathogenesis of neurodegenerative disorders. …”
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Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages by Tomoharu Kanie, Roy Ng, Keene L Abbott, Niaj Mohammad Tanvir, Esben Lorentzen, Olaf Pongs, Peter K Jackson

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Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton by Brendan W. Mormile, Yan Yan, Taran Bauer, Li Wang, Rachel C. Rivero, Sara C. D. Carpenter, Catherine Danmaigona Clement, Kevin L. Cox, Lin Zhang, Xiyu Ma, Terry A. Wheeler, Jane K. Dever, Ping He, Adam J. Bogdanove, Libo Shan

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Ensino religioso e a formação do ser humano na perspectiva da interculturalidade by Eliane Ludwig

“…Currently, the RE, according to Art. 33 of the Law of Directives and Bases of National Education (LDB) No 9394 / 96 is binding offer for discipline in elementary school, optional registration, and integral part of the baric trailing of citizens constituted discipline normal hours of teaching in public schools with responsibility for ensuring respect for cultural diversity Religious in Brazil, without any form of proselytizing.…”
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Research Progress in Plant Antiviral Silencing: Argonaute-Centered Perspective by Zhaoyun WANG, Jinli XIONG, Xiu WANG

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RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation by Sadiq Umar, Wuqiang Zhu, Fernando Souza-Neto, Ingrid Bender, Steven C. Wu, Chastity L. Healy, Timothy D. O’Connell, Jop H. van Berlo

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Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling by Ngoc-Thac Pham, Huong-Giang Le, Bo-Rong Peng, Lo-Yun Chen, Mohamed El-Shazly, Jui-Hsin Su, Mei-Hsien Lee, Kuei-Hung Lai

“…This integrative approach demonstrates the power of computational methods in drug discovery, highlighting the potential of zoanthamine alkaloids as lead compounds for innovative osteoporosis therapies.…”
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COMPOUNDING WATERPROOF COMPOSITE PLASTER KNITTING WITH COMPONENTS OF TECHNOGENIC ORIGINS by A. H. Alaskhanov, S. A. Aliev, S-A. Y. Murtazaev, A. S. Uspanova

“…The article presents the results of studies of the composition of the reconstituted composite gypsum binding to integrated power plant ash waste Grozny. …”
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Multi-omics reveals the polyethylene terephthalate carcinogenicity: Cancer progression and immune microenvironment by Kangping Yang, Xianhuan Zhou, Kai Wu, Jiaqiang Wu, Chunxia Huang, Liang Yang

“…Molecular docking revealed six high-affinity PET-binding targets (PIK3CA, TOP2A, PARP1, SRC, EP300, CREBBP; binding energies <−6.0 kcal/mol) predominantly expressed in T-cells and phagocytic cells, with significant infiltration into malignant tumor regions. …”
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A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation by Thanh Tai Duong, Danny De Sarno, Hatim Fakir, Glenn Bauman, Martin Martinov, Rowan M. Thomson, Ting-Yim Lee, Ting-Yim Lee, Ting-Yim Lee

“…PurposeTheranostics integrates diagnostic imaging (e.g., 18F-PSMA-1007 PET) with targeted radioligand therapy (TRT; e.g., 177Lu-PSMA-617), but personalized dosimetry remains challenging due to complex dose calculations. …”
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<i>Alternaria alternata</i> (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication by Darian Naidu, Ernest Oduro-Kwateng, Mahmoud E. S. Soliman, Sizwe I. Ndlovu, Nompumelelo P. Mkhwanazi

“…The crude extract had antiviral activity during attachment, reverse transcription, integration, and proteolysis. In silico calculations showed compounds 2,3-2H-Benzofuran-2-one, 3,3,4,6-tetramethyl-, 3-Methyl-1,4-diazabicyclo[4.3.0]nonan-2,5-dione, N-acetyl, Coumarin, 3,4-dihydro-4,5,7-trimethyl-, Cyclopropanecarboxamide, N-cycloheptyl, Pyrrolo[1,2-a]pyrazine-1,4-dione, and hexahydro-3-(2-methylpropyl)- crude extract bioactive compounds had strong docking scores and diverse binding mechanisms with integrase. …”
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Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders by Duraisamy Kempuraj, Kirk D. Dourvetakis, Jessica Cohen, Daniel Seth Valladares, Rhitik Samir Joshi, Sai Puneeth Kothuru, Sai Puneeth Kothuru, Tristin Anderson, Baskaran Chinnappan, Amanpreet K. Cheema, Nancy G. Klimas, Nancy G. Klimas, Theoharis C. Theoharides, Theoharis C. Theoharides

“…Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding of brain disorders and neurotherapeutics. Integration of these markers in clinical practice could potentially enhance early diagnosis, monitor disease progression, and improve therapeutic outcomes.…”
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Precise stratification of prognosis in pancreatic ductal adenocarcinoma patients based on pre- and postoperative genomic information by Kokichi Miyamoto, Ryuichi Yoshida, Kazuya Yasui, Kunitoshi Shigeyasu, Kazuhiro Yoshida, Tomokazu Fuji, Kosei Takagi, Yuzo Umeda, Kazuyuki Matsumoto, Yuki Fujii, Toshiaki Takahashi, Kazuya Moriwake, Masashi Kayano, Takeyoshi Nishiyama, Yasuo Nagai, Hideki Yamamoto, Hironari Kato, Hiroshi Tazawa, Mizuki Morita, Motoyuki Otsuka, Toshiyoshi Fujiwara

“…Although the resectability status, tumour marker, KRAS circulating tumour DNA (mutKRAS-ctDNA) mutations, and GATA binding 6 (GATA6) expression status are promising prognostic biomarkers, their effective integration before and after surgery remains unclear. …”
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Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in Escherichia coli by Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

“…Utilizing this dataset, we have developed various machine learning models and discovered that the integration of promoter regions, ribosome binding sites, and coding sequences significantly improves the accuracy of predicting protein expression levels, with a Spearman correlation coefficient of 0.72, where the promoter sequence exerts a predominant influence. …”
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Synthesis, antioxidant, antimicrobial activities and molecular modeling analysis of some 5-Nitro-N-phenyl-3-(phenylamino)-1H-indazole-1-carboxamide derivatives: Docking, SAR, toxic... by Mithlesh Yadav, Suraj N. Mali, Bharti Sharma, Haya Yasin, Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Archana Kapoor

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The concept of natural genome reconstruction. Part 1. Basic provisions of the “natural genome reconstruction” concept. Changing the genome of hematopoietic stem cells using several... by L. A. Yakubov, O. S. Taranov, S. V. Sidorov, S. D. Nikonov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Specific groups of glycocalyx factors, including glycoproteins/proteoglycans, glycosylphosphatidylinositol-anchored proteins and scavenger receptors, take part in the internalization event. The binding sites for DNA fragments are heparin-binding domains and clusters of positively charged amino acid residues that are parts of protein molecules of these factors. …”
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A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions by Davide Moiani, Davide Moiani, Davide Moiani, John A. Tainer, John A. Tainer, John A. Tainer

“…Two VS per library and multiple ranked ligand binding poses enable target testing for several DDR targets. …”
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The attitude of medical students toward applying virtual dissection table in the learning anatomy of thorax by Hamid Hojatdoost, Forouzan Kavarizadeh, Leila Noori, Vali Baigi, Yousef Mohamadi

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Les belles idées de la défigurée : à propos du plateau labial des Mursi (Ethiopie) by Jean-Baptiste Eczet

“…Beyond a counter argumentation on the stereotypes, I will try to show that the lip-plate has several modes of action, all within the praxis of the body to which it is integral. The layers of meaning, pragmatic challenges and the perceptual impacts accumulated by this simple object must be stripped away. …”
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