Unitization Based Memory Enhancement in Younger and Older Adults by Joshua Kah Meng Khoo, Roni Tibon

“…Unitization—the encoding of multiple items as one integrated entity—has been shown to support familiarity-based retrieval that is independent of recollection and is relatively preserved in healthy ageing. …”
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KONSEPTUALISASI PENYELESAIAN SENGKETA KONSUMEN MELALUI SMALL CLAIMS PROSEDURE DI INDONESIA by Anita Afriana, Rai Mantili, Ema Rahmawati

“…The results showed that consumer dispute resolution in the court with a small claim value was not balanced with the mechanism of proceedings in the court, while the power of the decision through BPSK resolution was not final and binding. Small Claims Procedures are solutions that integrate informal and formal mechanisms as one of the concrete steps to achieve legal certainty in resolving consumer disputes in Indonesia. …”
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Flipping the Target: Evaluating Natural LDHA Inhibitors for Selective LDHB Modulation by Amanda El Khoury, Christos Papaneophytou

“…These findings were strongly supported by molecular docking analyses, which revealed that both compounds bind at an allosteric site located at the dimer interface, closely resembling the binding mode of the established LDHB uncompetitive inhibitor AXKO-0046. …”
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Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway. by Ying Wang, Jiaqi Wang, Liangen Chen, Wenjing Zhou, Haifeng He, Xiyuan Chen, Haiying Wang

“…Docking results confirmed that prolyl hydroxylase (PHD) was the most possible target for unsaturated binding with Pinacidil guanidine. Altogether, these data indicate that Pinacidil up-regulated and activated HIF-1α protein to protect caridomyocytes against HR injuries and the mechanism may be related to Pinacidil guanidine binding to PHD.…”
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Network Pharmacology, Molecular Docking, and Molecular Dynamics Analysis of Honokiol against Triple-negative Breast Cancer by Hassan H. Alhassan

“…Molecular docking simulations revealed the binding modes and affinity of honokiol with key target proteins implicated in TNBC progression. …”
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Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

“…Moreover, limited data on antigen-antibody binding in public databases constrains the training of machine learning models. …”
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Molecularly imprinted polymer-based sensors: Design and advances in the analysis of DNA and protein by Arzum Erdem, Huseyin Senturk, Mehmet Karakus

“…The rationale behind jointly addressing protein and DNA analysis lies primarily in the shared challenges presented by these biomolecules, such as molecular size, structural complexity, and specificity of binding. Furthermore, similar analytical approaches and transduction mechanisms employed in the sensor designs for these two groups allow for a more comprehensive and integrated evaluation. …”
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Phthalates unleashed: decoding ovarian carcinogenesis through multi-omics networks, single-cell insights, and molecular docking by Junchan Yang, Min Luo, Hongjun Wang, Jinfa Huang

“…Conclusions Integrated computational analyses indicate that phthalates (DEP, DMP, DOP) may drive ovarian carcinogenesis through metabolic reprogramming (HIF-1α/glycolysis), strong binding to SIRT1/PPARα regulators, and tumor microenvironment remodeling. …”
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Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. by Anthony Antonellis, Jimmy L Huynh, Shih-Queen Lee-Lin, Ryan M Vinton, Gabriel Renaud, Stacie K Loftus, Gene Elliot, Tyra G Wolfsberg, Eric D Green, Andrew S McCallion, William J Pavan

“…Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression. …”
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SweetBac: a new approach for the production of mammalianised glycoproteins in insect cells. by Dieter Palmberger, Iain B H Wilson, Imre Berger, Reingard Grabherr, Dubravko Rendic

“…The mammalianised variants of 3D6 showed highly specific binding to the lectin, indicating proper functionality. …”
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Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8 by Jun-Qi Yang, Chen Wang, Ramesh C. Nayak, Manohar Kolla, Mingjun Cai, Mario Pujato, Yi Zheng, Q. Richard Lu, Fukun Guo

“…RNA-seq and ATAC-seq revealed that CHD8 deletion upregulated a number of pathways, notably mammalian target of rapamycin complex 1 (mTORC1) signaling and its mediated glycolysis that have been reported to promote Treg plasticity. Integrating RNA-seq data with CHIP-seq and ATAC-seq data identified a number of CHD8 target genes whose expression depends on CHD8 direct binding-mediated chromatin remodeling. …”
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Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors by Scott B. Ficarro, Zachary H. Marto, Nicholas M. Girardi, Dingyu Deng, Isabella Jaen Maisonet, Guillaume Adelmant, Laura E. Fleming, Mona Sharafi, Isidoro Tavares, Andrew Zhao, HyoJeon Kim, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sara J. Buhrlage, Jarrod A. Marto

“…Our platform comprises automated, dual LC desalting columns integrated with electrospray ionization for rapid sample introduction and mass spectrometry detection. …”
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The Strategies to use the Abandoned Agricultural Lands around Sanandaj by Reza Movahedi, Sina Javanmardi

“…Therefore, it is necessary to manage this problem by establishing basic and transparent laws and enforcing binding policies on land uses around the city with serious planning and monitoring. …”
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Bacterial biofilm-derived H-NS protein acts as a defense against Neutrophil Extracellular Traps (NETs) by AL Hendricks, KR More, A. Devaraj, JR Buzzo, FH Robledo-Avila, S. Partida-Sanchez, LO Bakaletz, SD Goodman

“…This transition to Z-DNA increases biofilm rigidity and prevents binding by canonical B-DNA-binding proteins, including nucleases. …”
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Characteristics of exopolysaccharides - egg white protein composite gel and its application in low - fat sausage by Guoguo Jin, Man Zhang, Xinran Wang, Yifan Zhang, Guohua Jiang, Lin Mei

“…Molecular docking (MD) analysis revealed favorable binding conformations and strong binding energies between ovalbumin (OVA) and EPS, particularly through the formation of specific pockets involving interactions with residues such as Lysine (Lys) and Aspartic acid (Asp). …”
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Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis by Deepanjali Shukla, Iqbal Azad, Mohd Arsh Khan, Ziaul Husain, Azhar Kamal, Sabahat Yasmeen Sheikh, Ibrahim Alotibi, Varish Ahmad, Firoj Hassan

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Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells by Jiahao Jiang, Thomas K. Hiron, Anil Chalisey, Yashaswat Malhotra, Thomas Agbaedeng, Chris A. O’Callaghan

“…We further demonstrate that ox-LDL activates endothelial cell migration through the epigenomic rewiring of transcription factor binding. Notably, these ox-LDL-induced dynamic binding sites are enriched for the genetic risk of coronary artery disease, enabling the discovery of the gene-environment interaction of rs62172376 and ox-LDL at the CALCRL/TFPI locus. …”
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Imperata cylindrica L. Rhizome: Network pharmacology and molecular docking analysis of active ingredients and their mechanisms of action in treating acute kidney injury by Rizal Dzulfaqaar Alauddin Daffa, Madyastuti Purwono Rini, Harlina Eva, Safithri Mega, Widyastuti Rini

“…The docking results indicated strong binding interactions, suggesting therapeutic potential. …”
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A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein by Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

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High‐Throughput MicroED for Probing Ion Channel Dynamics by Marc J Gallenito, Max TB Clabbers, Jieye Lin, Johan Hattne, Tamir Gonen

“…From a subset of NaK structures, consistent sodium binding at specific sites is observed. In contrast, NaK2CNG appears more dynamic and undergoes dilation of the selectivity filter upon potassium binding. …”
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