Identify key transcript factors of adipocyte differentiation in abdominal fat of broilers based on ATAC-seq and RNA-seq by Xiaoying Liu, Chaohui Wang, Xi Sun, Zhihao Qiao, Xiaojun Yang, Yanli Liu

“…Furthermore, MYB and NFIX exhibited potential binding sites in the promoter regions of lipid metabolism-related genes (ELOVL6, PPARγ, FABP4, ACACA and SCD). …”
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Heavy Metal Ion Detection Based on Lateral Flow Assay Technology: Principles and Applications by Xiaobo Xie, Xinyue Hu, Xin Cao, Qianhui Zhou, Wei Yang, Ranran Yu, Shuaiqi Liu, Huili Hu, Ji Qi, Zhiyang Zhang

“…In the future, the development of lateral flow assay technology for detection of heavy metal ions will focus on multiplex detection, optimization of signal amplification strategies, integration with portable devices, and standardization and commercialization. …”
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A streamlined procedure for advancing the detection and isolation of Listeria monocytogenes from artificially contaminated ground beef in a single working day by Min Lin, Hanhong Dan, Jiewen Guan

“…The RTi-PCR-based molecular detection method integrated into the workflow was capable of detecting pure cultures of L. monocytogenes as low as 12.5 CFUs. …”
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Safety, immunogenicity and pregnancy outcomes in mothers and infants after vaccination with an adenovirus-vector COVID-19 vaccine during pregnancy by Gloria Aguilar, Gabriela Tapia-Calle, Cynthia Robinson, Benoit Baron, David Lowson, Bassem Maximos, Veronica V. Rezelj, Anne Marit de Groot, Nicole Bet, Vitalija van Paassen, Mathieu Le Gars, Frank Struyf, Javier Ruiz-Guiñazú

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Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer by Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu

“…By integrating large‐scale population and biological experiments, a functional apaQTL variant rs9606 in LYRM4 is identified. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Regulatory network reconstruction identified 32 transcription factors, 24 RNA-binding proteins, and 62 miRNAs as putative upstream regulators of key genes. …”
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Identification and expression profile analysis of circRNAs associated with goat uterus with different fecundity during estrous cycle by Xiaolong Du, Yufang Liu, Xiaoyun He, Lin Tao, Meiying Fang, Mingxing Chu

“…A total of 7,445 circRNAs were identified through the integration of findings from find_circ and CIRI2 software. …”
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A Systematic Review of SNPs Screening for Platinum-Related Pharmacodynamics and Pharmacokinetics Genes in Non-Small Cell Lung Cancer for Precision Medicine by Afifah NN, Larasati AL, Wijaya I, Zakiyah N, Intania R, Obinata H, Barliana MI

“…Previous research has predominantly focused on genetic polymorphisms in genes like Glutathione S-transferase Pi 1 (GSTP1), ATP Binding Cassette subfamily C member 2 (ABCC2), Excision repair cross-complementation group 1 and 2 (ERCC1, and/ ERCC2), which play crucial roles in detoxification, drug transportation, and Nucleotide Excision Repair (NER). …”
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CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability by Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Victor S. Batista

“…We have made all of our software open-source at https://github.com/gregory-kyro/CardioGenAI to facilitate integration of the CardioGenAI framework for molecular hypothesis generation into drug discovery workflows. …”
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Molecularly imprinted polymer technology for electrochemical detection of diabetes-related biomarkers by Launa Silky Karenindra Rokhmat, Irkham, Serly Zuliska, Adisyahputra, Yohanes Susanto Ridwan, Retna Putri Fauzia, Putra Rafli Ramdani, Yeni Wahyuni Hartati

“…The continued development of MIPs-based electrochemical sensors holds great potential for enhancing the accessibility and efficiency of DM biomarker detection, with ongoing research paving the way for their integration into point-of-care diagnostic platforms.…”
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Distinct oligomeric assemblies of STING induced by non-nucleotide agonists by Anant Gharpure, Ariana Sulpizio, Johannes R. Loeffler, Monica L. Fernández-Quintero, Andy S. Tran, Luke L. Lairson, Andrew B. Ward

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Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks by Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe

“…CLL samples displayed a H3K4me3 redistribution and nucleosome gain at promoters as well as changes of enhancer activity and enhancer linkage to target genes. A DNA binding motif analysis identified transcription factors that gained or lost binding in CLL at sites with aberrant chromatin features. …”
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Determination of Dissociation Constants for the Interaction of Myosin-5a with its Cargo Protein Using Microscale Thermophoresis (MST) by Rui Zhou, Jiabin Pan, Xiang-Dong Li

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Exploring Chemokine Homodimer Stability: Structural Insights into CXC and CC Interfaces by David Budean, Yasser Almeida-Hernández, Jitendra Pandey, Joel Mieres Pérez, Elsa Sánchez García, Ellinor Haglund

“…Understanding their sequence and structural integrity is crucial for elucidating their biological functions and potential therapeutic applications. …”
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Nanodesigner: resolving the complex-CDR interdependency with iterative refinement by Melissa Maria Rios Zertuche, Şenay Kafkas, Dominik Renn, Magnus Rueping, Robert Hoehndorf

“…Abstract Camelid heavy-chain only antibodies consist of two heavy chains and single variable domains (VHHs), which retain antigen-binding functionality even when isolated. The term “nanobody” is now more generally used for describing small, single-domain antibodies. …”
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Characterizing somatic mutations in ovarian cancer germline risk regions by Ping-Hung Lai, Jonathan P. Tyrer, Paul Pharoah, Simon A. Gayther, Michelle R. Jones, Pei-Chen Peng

“…We investigate somatic events, including mutational signatures, point mutations, copy number alterations, and transcription factor binding disruptions, within 33 EOC germline susceptibility regions. …”
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Defining the Protein Phosphatase 2A (PP2A) Subcomplexes That Regulate FoxO Transcription Factor Localization by Adeline M. Luperchio, Daniel J. Salamango

“…Functional, genetic, and biochemical studies combine to identify the PP2A complexes that regulate FoxO nuclear translocation, and the binding motif required. Mutating the FoxO-PP2A interface to enhance or diminish PP2A binding alters nuclear translocation kinetics accordingly. …”
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Molecular dynamics simulation based prediction of T-cell epitopes for the production of effector molecules for liver cancer immunotherapy. by Sidra Zafar, Yuhe Bai, Syed Aun Muhammad, Jinlei Guo, Haris Khurram, Saba Zafar, Iraj Muqaddas, Rehan Sadiq Shaikh, Baogang Bai

“…Based on immunoinformatic and integrated machine learning tools, we predicted the potential therapeutic vaccine candidates of liver cancer. …”
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Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support. by Natalie Di Bartolo, Emma L R Compton, Tony Warne, Patricia C Edwards, Christopher G Tate, Gebhard F X Schertler, Paula J Booth

“…The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families, such as G protein coupled receptors (GPCRs). …”
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The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer. by Saliha Ece Acuner Ozbabacan, Attila Gursoy, Ruth Nussinov, Ozlem Keskin

“…In silico mutagenesis and comparison of the predicted binding energies reveal the mechanisms of how oncogenic and single nucleotide polymorphism (SNP) mutations can abrogate the interactions or increase the binding affinity of the mutant to the native partner. …”
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