Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights by Ni-ren Li, Yi-xuan Zeng, Yu-feng Gu, Pai Xie, Bing-ying Deng, Si-fan Lu, Wang-an Li, Yi Liu

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A computational approach to mycolic acid biosynthesis disruption in mycobacterium tuberculosis via molluscan metabolites as KasA inhibitors by Abdullah R. Alanzi, Fatimah Mohammed Alsulais, Bayan Abdullah Alhaidhal

“…Inhibition of KasA could disrupt the integrity of the mycobacterial cell wall, which is crucial for its survival and virulence. …”
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Molecular basis of F-actin regulation and sarcomere assembly via myotilin. by Julius Kostan, Miha Pavšič, Vid Puž, Thomas C Schwarz, Friedel Drepper, Sibylle Molt, Melissa Ann Graewert, Claudia Schreiner, Sara Sajko, Peter F M van der Ven, Adekunle Onipe, Dmitri I Svergun, Bettina Warscheid, Robert Konrat, Dieter O Fürst, Brigita Lenarčič, Kristina Djinović-Carugo

“…Myotilin binds to Z-disc components, including F-actin and α-actinin-2, but the molecular mechanism of binding and implications of these interactions on Z-disc integrity are still elusive. …”
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Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation by Xicheng Hu, Zhen Wang, Liyan Zhang

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TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma by Alexandra Helleux, Guillaume Davidson, Antonin Lallement, Fatima Al Hourani, Alexandre Haller, Isabelle Michel, Anas Fadloun, Christelle Thibault-Carpentier, Xiaoping Su, Véronique Lindner, Thibault Tricard, Hervé Lang, Nizar M Tannir, Irwin Davidson, Gabriel G Malouf

“…High nuclear accumulation of NONO-TFE3 or PRCC-TFE3 fusion proteins promotes their broad binding across the genome at H3K27ac-marked active chromatin, engaging a core set of M/E-box-containing regulatory elements to activate specific gene expression programs as well as promiscuous binding to active promoters to stimulate mRNA synthesis. …”
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Glycan-Lectin interactions between platelets and tumor cells drive hematogenous metastasis by Longqiang Shu, Shanyi Lin, Shumin Zhou, Ting Yuan

“…During platelet-tumor-cell interactions, many opportunities for glycan-ligand binding emerge. This review integrates the latest information about glycans, their ligands, and how they mediate platelet-tumor interactions. …”
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Phytocompounds in Precision Dermatology: COX-2 Inhibitors as a Therapeutic Target in Atopic-Prone Skin by Muhammad Suleman, Abrar Mohammad Sayaf, Chiara Moltrasio, Paola Maura Tricarico, Francesco Giambuzzi, Erika Rimondi, Elisabetta Melloni, Paola Secchiero, Annalisa Marcuzzi, Angelo Valerio Marzano, Sergio Crovella

“…Molecular dynamics simulations over 200 ns, combined with MM/GBSA binding free energy calculations, consistently identified Tophit1 and Tophit2 as the most stable complexes, exhibiting exceptional structural integrity and a strong binding affinity to the target protein. …”
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Expression of kiwifruit-derived actinidin in Nicotiana benthamiana leaves by Ji Hyun Kang, Jae-Ho Lee, Dong Wook Lee, Dong Wook Lee, Dong Wook Lee

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Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions by Mohammed Alrouji, Kumar Venkatesan, Mohammed S. Alshammari, Fahad A. Alhumaydhi, Sheeba Shafi, Sharaf E. Sharaf, Moyad Shahwan, Anas Shamsi

“…Both molecules showed higher binding affinity than reference inhibitor droxinostat. …”
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Universally Recognized International Legal Principles and Norms and International Treaties as Part of the Legal System of the Republic of Kyrgyzstan by B. D. Kadyralieva

“…According to para. 3 art.12 of the Law of the Republic of Kyrgyzstan “About the New Edition of the Constitution of the Republic of Kyrgyzstan” international treaties and agreements of Kyrgyzstan and universally recognized international legal principles and norms are an integral part of the legal system of the Republic of Kyrgyzstan.In this respect it is necessary to mention that legal system should not be mistaken with the legislative system, as the legislative system means the total sum of national legal norms including constitutional norms, legal norms, etc. …”
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Anonymous trust management scheme of VANET based on attribute signature by Min XIAO, Faying MAO, Yonghong HUANG, Yunfei CAO

“…Trust management mechanisms can solve the authenticity assessment problem of messages and establish trust between communication entities in the VANET.However, current trust management schemes lack an effective privacy protection mechanism, leading to privacy concerns for vehicles when binding their identity with their trust level.Based on the anonymity of attribute-based signature, an anonymous trust management scheme was proposed for VANET.The trust level of the vehicle was maintained by the trusted authority.The trust level of vehicles and the current time were taken as the attribute identity set of the vehicle, so as to realize the binding of the anonymous vehicle identity with its trust level, which could provide the privacy protection of vehicles.In addition, the timely update of attribute signature private key could resist false reputation attack and the trust level of the vehicle could be verified anonymously while the attribute signature was verified.Furthermore, the pseudonym was used to hide the real identity of the vehicle, enabling only the trusted authority could parse the real identity of vehicles from the pseudonym to update their trust level, and providing legal and secure tracking of the malicious vehicle identity vehicle.Under the general group model, the attribute-based signature scheme is proven to satisfy the security of unforgerability.The security analysis further shows that the scheme protects the identity and location privacy of vehicles, enables only the trusted authority to legally track malicious vehicles, resists false reputation attacks, ensures communication integrity, and resists replay attacks.Performance analysis confirms that the proposed scheme has better computation and communication efficiency than existing schemes.…”
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Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. by Rhodri M L Morgan, Laura C Hernández-Ramírez, Giampaolo Trivellin, Lihong Zhou, S Mark Roe, Márta Korbonits, Chrisostomos Prodromou

“…These C-terminal AIP mutations appear to only disrupt client-protein binding to the Cα-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Cα-7h is sufficient to predispose to pituitary adenoma. …”
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Kepastian Hukum Putusan Dewan Kehormatan Penyelenggara Pemilu Terhadap Pelanggaran Kode Etik Penyelenggara Pemilu by Firda Arifatuzzahrah, Irham Bashori Hasba

“…The final and binding of DKPP’s decision has no legal impact because it can be eliminated with PTUN’s decision. …”
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Structural insights into thraustochytrid-specific lipases using alphafold to identify the role of GXSXG motif by Iqra Mariam, Ulrika Rova, Paul Christakopoulos, Leonidas Matsakas, Alok Patel

“…Abstract Background Triacylglycerol lipases (E.C. 3.1.1.3) are serine hydrolases, universally present in animals, plants and microbes and are an integral part of lipid metabolism. They are industrially relevant enzymes that cleave ester bonds of triacylglycerides to release free fatty acids and glycerol. …”
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Biochemical characterization of zebrafish Paqr5b by Md Sohanur Rahman Sohan, Md Forhad Hossain, Shakhawat Hossain, Yuki Omori, Mohammad Tohidul Amin, Md Ekramul Hasan, Toshinobu Tokumoto

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Molecular dynamics simulations involving different β-propeller mutations reported in Swiss and French patients correlate with their disease phenotypes by Finola Priyadharshini Chandrasekaran, Everette Jacob Remington Nelson

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CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer by Zhengkun Cai, Zeyuan Cheng, Lu Zhang, Yuhan Zhang, Jinming Shi, Jing Jin, Zeyun Mi, Zhiyong Yuan, Zhiqiang Wu

“…Abstract Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therapeutics, demonstrating remarkable clinical potential. …”
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Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration by Junyi Zhu, Yijia Zhang, Yinuo Sun, Fangzheng Yu, Yang Lu, Qianqian Hu, Jiali Guo, Haijuan Zhang, Tianling Chen, Feifei Lian, Jian Wang, Xiaokun Li, Jian Xiao

“…This also establishes a theoretical foundation for exploring the integration and clinical translation between nanomaterials and biotherapy.…”
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Machine learning-assisted analysis of serum metabolomics and network pharmacology reveals the effective compound from herbal formula against alcoholic liver injury by Jiamu Ma, Peng Wei, Xiao Xu, Ruijuan Dong, Xixi Deng, Feng Zhang, Mengyu Sun, Mingxia Li, Wei Liu, Jianling Yao, Yu Cao, Letian Ying, Yuqing Yang, Yongqi Yang, Xiaopeng Wu, Gaimei She

“…It was postulated that the effective compounds would bind with key targets from the PI3K-AKT signaling pathway, as indicated by the prediction model of compound-target interaction (R2 > 0.95). …”
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Ru Single Atoms Anchored on Oxygen‐Vacancy‐Rich ZrO2‐x/C for Synergistically Enhanced Hydrogen Oxidation by Xiaojuan Zhang, Chunchang Wang, Wenjun Cao, Qingqing Zhu, Chao Cheng, Jun Zheng, Haijuan Zhang, Youming Guo, Shouguo Huang, Yi Yu, Binghui Ge, Dongsheng Song, Yameng Fan, Zhenxiang Cheng

“…Density functional theory (DFT) simulations reveal that the integration of Ru atoms into ZrO2‐x/C optimizes both the hydrogen bonding energy (HBE) and hydroxyl binding energy (OHBE), reducing the toxicity of Ru sites. …”
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