The role of ATP-binding Cassette subfamily B member 6 in the inner ear by Stefanie A. Baril, Katie A. Wilson, Md Munan Shaik, Yu Fukuda, Robyn A. Umans, Alessandro Barbieri, John Lynch, Tomoka Gose, Alexander Myasnikov, Michael L. Oldham, Yao Wang, Jingwen Zhu, Jie Fang, Jian Zuo, Ravi C. Kalathur, Robert C. Ford, Allison Coffin, Michael R. Taylor, Megan L. O’Mara, John D. Schuetz

Get full text

Integrating single-cell sequencing analysis, bioinformatics analysis, and Mendelian randomization analysis to explore FABP4 prediction of prognosis and immune microenvironment in p... by Shun Gao, Xia Long, Jiawei Li, Xialin Zhang, Youhua Wang, Sheng Lin

Get full text

MEF-AlloSite: an accurate and robust Multimodel Ensemble Feature selection for the Allosteric Site identification model by Sadettin Y. Ugurlu, David McDonald, Shan He

“…Scientific Contribution Prior to conducting feature selection for allosteric binding site identification, integration of supporting amino-acid–based information to 3D structural knowledge is advantageous. …”
Get full text

A larval specific OBP able to bind the major female sex pheromone component in Spodoptera exigua (Hübner) by Rong JIN, Nai-yong LIU, Yan LIU, Shuang-lin DONG

Get full text

Altered glycosylation of EVs in cancers: galectin-3-binding protein (LGALS3BP) by Jie-Yi Koh Kok, Bey-Hing Goh, Wai-Leng Lee

“…Integration of these elements into biomarker panels holds promise for early cancer detection. …”
Get full text

Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties by Desmond Owusu Kwarteng, Alexander Wolf, Madisyn Langdon, Nawal Kassas, Nicolas Vitale, Edgar Eduard Kooijman

Get full text

Research on Plant RNA-Binding Protein Prediction Method Based on Improved Ensemble Learning by Hongwei Zhang, Yan Shi, Yapeng Wang, Xu Yang, Kefeng Li, Sio-Kei Im, Yu Han

“…(1) RNA-binding proteins (RBPs) play a crucial role in regulating gene expression in plants, affecting growth, development, and stress responses. …”
Get full text

Design of Aromatic Interaction Networks in a Protein Cage Modulated by Fluorescent Ligand Binding by Yuki Hishikawa, Taiga Suzuki, Basudev Maity, Hiroki Noya, Michito Yoshizawa, Asuka Asanuma, Yuri Katagiri, Satoshi Abe, Satoru Nagatoishi, Kouhei Tsumoto, Takafumi Ueno

Get full text

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation by Ramon Duran-Romaña, Bert Houben, Paula Fernández Migens, Ying Zhang, Frederic Rousseau, Joost Schymkowitz

Get full text

Innexin DNA-binding domains regulate Microplitis bicoloratus bracoviral transcription in symbiotic wasps by Hong-Mei Tang, Qiong-Li Zhang, Xin Qiao, Ming-Wu Dai, Yong-Sheng Yuan, Xue-Mei Tang, Wen-Ji Yang, Rui Jing, Xing-Cheng Li, Qi Zhang, Xiang Yan, Yin-Chen Ma, Yong-Biao Huang, Li-Xiang Zhou, Jin Long, Nan-Nan Peng, Chen-Hui Cai, Jiang-Hui Meng, Kai-Jun Luo

“…Here, we found that innexins (Inxs) of the Microplitis bicoloratus wasp (Mb-Inx1 and Mb-Inx2) contain DNA-binding domains that directly bind to, and regulate transcription promoters of the viral envelope genes MbBVp74 and MbBVe56-1. …”
Get full text

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization by Mia L Abramsson, Robin A Corey, Jan L Skerle, Louise J Persson, Olivia Anden, Abraham O Oluwole, Rebecca J Howard, Erik Lindahl, Carol V Robinson, Kvido Strisovsky, Erik G Marklund, David Drew, Phillip J Stansfeld, Michael Landreh

“…Integral membrane proteins carry out essential functions in the cell, and their activities are often modulated by specific protein-lipid interactions in the membrane. …”
Get full text

Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining by Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A. Khant, Richard T. Pomerantz, Xiaojiang S. Chen

“…Abstract DNA double-strand breaks (DSBs) present a critical threat to genomic integrity, often precipitating genomic instability and oncogenesis. …”
Get full text

Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles by Sónia Castanheira, Juan J. Cestero, Francisco García-del Portillo, M. Graciela Pucciarelli

“…The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. …”
Get full text

GNNSeq: A Sequence-Based Graph Neural Network for Predicting Protein–Ligand Binding Affinity by Somanath Dandibhotla, Madhav Samudrala, Arjun Kaneriya, Sivanesan Dakshanamurthy

“…<b>Background/Objectives:</b> Accurately predicting protein–ligand binding affinity is essential in drug discovery for identifying effective compounds. …”
Get full text

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR by Wessel A. C. Burger, Jesse I. Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R. Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M. Bender, Craig W. Lindsley, Yinglong Miao, Arthur Christopoulos, Celine Valant, David M. Thal

“…To identify the binding site of M5-selective PAMs, we implement an integrated approach combining mutagenesis, pharmacological assays, structural biology, and molecular dynamics simulations. …”
Get full text

Structure-activity relationship of PET-degrading cutinase regulated by weak Ca2+ binding and temperature by Fumiya Kondo, Narutoshi Kamiya, Gert-Jan Bekker, Satoshi Nagao, Nobutaka Numoto, Hiroshi Sekiguchi, Nobutoshi Ito, Masayuki Oda

Get full text

Investigation of the impact of a rotationally superimposed punch stroke on the binding mechanisms of a clinched joint by Lüder Stephan, Wolf Eugen, Schmale Hans Christian, Brosius Alexander

“…The primary objective was to evaluate the binding mechanisms that maintain the integrity of the clinched joint. …”
Get full text

The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics by Diana M. Norden, Carmen T. Navia, Jonathan T. Sullivan, Benjamin J. Doranz

Get full text

A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…Adenosine triphosphate-binding cassette (ABC) transporters form a ubiquitous superfamily of integral membrane proteins involved in the translocation of substrates across membranes. …”
Get full text

Moldrug algorithm for an automated ligand binding site exploration by 3D aware molecular enumerations by Alejandro Martínez León, Benjamin Ries, Jochen S. Hub, Aniket Magarkar

“…It offers pre-configured multi-parameter fitness functions for molecular design, while being highly adaptable for integrating functionalities from external software. …”
Get full text