Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation by Jiabei Lian, Yachun An, Wenjing Wei, Yao Lu, Xiyu Zhang, Gongping Sun, Haiyang Guo, Longjin Xu, Xuena Chen, Huili Hu

“…Mechanistically, we demonstrate that ATF3 binds to the promoter of Slc7a5 to activate mTOR signals while the Hmgcs1 promoter loses ONECUT2 binding to facilitate regenerative initiation. …”
Get full text

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion by Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu

“…This activation promotes phosphorylation of the interferon regulatory factor 7 (IRF7), which binds to the promoter region of SERTA‐containing domain 1 (SERTAD1, also called SEI1) gene to enhance its transcription. …”
Get full text

A novel tri-mode detection platform for ampicillin and drug resistance genes by CRISPR-driven luminescent nanozymes by Tao Zhang, Guiling Liu, Siwei Sun, Zongwu Meng, Yuzhe Qiu, Ping Ding

“…A PUM-based three-signal detection scheme was established for the sensitive determination of blaTEM with the limit of detection (LOD) of 1.03 pM. The integration of smartphone-assisted analysis broadens the potential of the platform for visual detection. …”
Get full text

Phycomediation of cadmium contaminated aqueous solutions using Chlamydomonas sp.: process optimization and adsorption characterization by Reem Mohammed Alharbi, Neveen Abdel-Raouf, Neveen Abdel-Raouf, Mostafa Shaaban Mohamed, Wael A. Fathy, Ibraheem Borie M. Ibraheem, Walaa Gamal Hozayen

“…These results support using Chlamydomonas as an effective biosorbent for integration into global industrial wastewater treatment systems. …”
Get full text

Nanomaterials for Direct Air Capture of CO₂: Current State of the Art, Challenges and Future Perspectives by Cataldo Simari

“…It has been reiterated that no single ‘best’ material exists, but rather a portfolio of technologies will be necessary, with the ultimate success dependent on system-level integration and the availability of low-carbon energy. …”
Get full text

SPOŁECZNE ASPEKTY STOSOWANIA „ZASADY” INTEGRALNOŚCI WYROKU ROZWODOWEGO by Elżbieta Holewińska-Łapińska

“… Social Aspects of Implementing the Rule of Integrity of a Divorce Verdict Summary The provisions regulating a divorce are binding on the whole Polish territory since 1 January 1946 The main consequences of adjudging a divorce should be included in the divorce verdict, and the court decides on them ex officio. …”
Get full text

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. by Emilie A Bard-Chapeau, Dorota Szumska, Bindya Jacob, Belinda Q L Chua, Gouri C Chatterjee, Yi Zhang, Jerrold M Ward, Fatma Urun, Emi Kinameri, Stéphane D Vincent, Sayadi Ahmed, Shoumo Bhattacharya, Motomi Osato, Archibald S Perkins, Adrian W Moore, Nancy A Jenkins, Neal G Copeland

“…The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). …”
Get full text

In SILICO Characterization of Technetium-99M Radiotracers: ADMET Properties and Protein Interaction Profiles by V. Trusova, U. Malovytsia, P. Kuznietsov, I. Yakymenko, G. Gorbenko

“…The results revealed that polarity, hydrogen bonding capacity, and molecular flexibility critically govern both pharmacokinetic properties and protein-binding profiles. Tracers such as TcSES and TcTET, with low topological polar surface area and minimal binding affinity, were associated with rapid clearance and are well suited for dynamic imaging protocols. …”
Get full text

Innovative CDR grafting and computational methods for PD-1 specific nanobody design by Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan

“…This study aims to design and characterize a PD-1-specific nanobody using an integrated computational and experimental approach.MethodsAn in silico design strategy was employed, involving Complementarity-Determining Region (CDR) grafting to construct the nanobody sequence. …”
Get full text

Discovery of CMNPD31124 as a novel marine-derived PKMYT1 inhibitor for pancreatic ductal adenocarcinoma therapy: computational and biological insights by Chaojie Huang, Ting Wang, Rui Chen, Yunyun Xu

“…Molecular dynamics simulations further demonstrated its stable binding conformation and dynamic adaptability, with Chai-1 modeling supporting a covalent binding mechanism at the PKMYT1 active site. …”
Get full text

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis by Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim

“…Chromatin immunoprecipitation verified binding of sterol regulatory element‐binding protein 1 (SREBP1) to acetyl‐CoA carboxylase (ACC) and fatty acid synthase (FASN) promoters. …”
Get full text

Cyberbullying of children: Challenges of victim support by Paunović Nikola

“…Bullying in the form of verbal, physical and social harassment is an integral problem for all societies. With the development of information and communication technology, cyberbullying of children as a new type of bullying increasingly attracts the attention of scholars. …”
Get full text

In silico investigation of acetylcholinesterase-insecticide interactions in Anopheles stephensi and Anopheles culicifacies using molecular docking by Harish Chandra Sha, Suvam Acharya, Bijayalaxmi Sahu, Tapan Kumar Barik

“…Molecular docking was performed using AutoDockVina and AutoDockTools to evaluate the binding affinities and interactions between the insecticides and the target AChE enzymes. …”
Get full text

Design synthesis, characterization, molecular docking and antimicrobial evaluation of novel heterocycles with acrylonitrile and anthracene moieties by Aya. I. Hassaballah, A. K. El-ziaty, Marwa M. Gado, Hayam A. E. Sayed, Mahmoud Kamal, Rania S. Ali

“…However, molecular docking studies revealed varied binding affinities for Penicillin-Binding Protein 2a (PBP2a), a crucial target in MRSA resistance. …”
Get full text

Characterization of the interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae. by Gunjan Piya, Erica N Mueller, Heather K Haas, Padmaja L Ghospurkar, Timothy M Wilson, Jaime L Jensen, Christopher L Colbert, Stuart J Haring

“…Maintaining the integrity of the genome requires the high fidelity duplication of the genome and the ability of the cell to recognize and repair DNA lesions. …”
Get full text

Novel fungal metabolites as dual cholinesterase inhibitors: A computational approach for Alzheimer's disease therapy. by Md Habib Ullah Masum, Syed Mohammad Lokman, Rehana Parvin, Md Shahidur Rahman, Erfanul Haq Chowdhury, Kazi Chamonara, Salma Chowdhury, Ahmad Abdullah Mahdeen, Mst Mitu Khatun

“…As determined by binding energy calculations, Hericenone J had the most inhibitory potential, followed by Lovastatin. …”
Get full text

Computational Design and Synthesis of Phthalimide Derivatives as TGF-β Pathway Inhibitors for Cancer Therapeutics by Héctor M. Heras-Martínez, Blanca Sánchez-Ramírez, Linda-Lucila Landeros-Martínez, Víctor H. Ramos-Sánchez, Alejandro A. Camacho-Dávila, Kostiantyn O. Marichev, Alejandro Bugarin, David Chávez-Flores

“…Molecular docking studies targeted the TGF-β protein (PDB: 1RW8) at the ALK5 binding site. On this study fourteen molecules were evaluated (<b>P1</b>–<b>P14</b>) and six (<b>P1</b>, <b>P3</b>, <b>P4</b>, <b>P5</b>, <b>P7</b>, and <b>P13</b>) demonstrated promising binding values. …”
Get full text

Mechanism of nimodipine in treating neurodegenerative diseases: in silico target identification and molecular dynamic simulation by Shuang Zheng, Shuang Zheng, Shuang Zheng, Yin Wang, Shuainan Tang, Yuntao Guo, Duan Ma, Xin Jiang

“…MAOA, with the highest binding energy of −7.343 kcal/mol, demonstrated a stable structure in a 100ns dynamic simulation with nimodipine, exhibiting an average dynamic binding energy of −52.39 ± 3.05 kcal/mol. …”
Get full text

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD by Rang-yue Han, Rui-zhi Tan, Ling-hui Xu, Jing-yi Lin, Tong Li, Hong-wei Su, Ping Li, Peng Liu, Hui-yao Lan, Li Wang

Get full text

Suppressing lipid biosynthesis in Mycobacterium tuberculosis through polyketide synthase 13 thioesterase inhibition: Insights from computational analysis by Maha M. Alawi, Hattan S. Gattan, Azzah S. Alharbi, Mohammed H. Alruhaili, Ibrahim A. Al-Zahrani, Saad B.AL Masaud, Vivek Dhar Dwivedi, Esam I. Azhar

“…Mycolic acid biosynthesis is essential for the integrity of Mtb's cell wall, offering promising therapeutic intervention targets. …”
Get full text