Therapeutic potential of recombinant IL-22BP in psoriasis: suppression of IL-22/STAT3 signaling in mice by Xiuze Chen, Tao Zeng, Fang Fang, Qinyu Tian, Yingying Li, Wenlin Zhou, Binqian Gong, Na Tian, Jizhou Zhang, Yechen Xiao

“…IL-22 binding protein (IL-22BP) exhibits a binding affinity for IL-22 that far surpasses that of IL-22RA1 and functions as a natural antagonist of IL-22. …”
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ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair by Yeongjae Kim, Na Young Ha, Mi-Sun Kang, Eunjin Ryu, Geunil Yi, Juyeong Yoo, Nalae Kang, Byung-Gyu Kim, Kyungjae Myung, Sukhyun Kang

“…Our research reveals that BAZ1B, a regulatory subunit of the BAZ1B-SMARCA5 chromatin-remodeling complex (also known as the WICH complex), plays a crucial role in fine-tuning the de-ubiquitination process of Ub-PCNA. The BAZ1B binding region of ATAD5 encompasses the UAF1-binding domain of ATAD5. …”
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ProbC: joint modeling of epigenome and transcriptome effects in 3D genome by Emre Sefer

“…Even though both techniques do not directly depend on the binding of specific antibodies, previous work has revealed enriched interactions and domain structures around multiple chromatin marks; epigenetic modifications and transcription factor binding sites. …”
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…It has been proposed that Tspan12 integrates into the Norrin-Fzd4 complex to enhance Norrin-Fzd4 affinity or otherwise allosterically modulate Fzd4 signaling. …”
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Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3 by Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl

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Differential modulation of SARS-CoV-2 infection by complement factor H and properdin by Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag

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Exploration of novel azole-quinoline hybrids as LdNMT inhibitors using in-silico approach; molecular docking, DFT, molecular dynamics simulations, MMGBSA and ADMET by Firoj Hassan, Waseem Ahmad Ansari, Sabahat Yasmeen Sheikh, Mohammad Faheem Khan, Tabrez Faruqui, Iqbal Azad, Maqsood A. Siddiqui, Abdulaziz A. Al-Khedhairy, Abdul Rahman Khan, Malik Nasibullah

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Targeting bone in cancer therapy: Advances and challenges of bisphosphonate-based drug delivery systems by Fariba Ganji, Mohammadmahdi Eshaghi, Hossein Shaki, Lobat Tayebi

“…In vitro assays (e.g. hydroxyapatite binding, cell viability) and in vivo biodistribution studies are discussed to evaluate targeting efficiency and therapeutic outcomes. …”
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Recombinant HMG1 Protein Produced in Pichia pastoris: A Nonviral Gene Delivery Agent by A.R. Mistry, L. Falciola, L. Monaco, R. Tagliabue, G. Acerbis, A. Knight, R.P. Harbottle, M. Soria, M.E. Bianchi, C. Coutelle, S.L. Hart

“…Non-glycosylated recombinant HMG1 was purified easily and shown to possess the same DNA-binding properties as HMG1 purified from calf thymus. …”
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Strain-induced variation in quantum dot emissions close to Si-vacancy transitions by Zhao An, Xin Cao, Maik Steinbach, Jürgen Koch, Peter Jäschke, Christian Laurio, Frederik Benthin, Yiteng Zhang, Chenxi Ma, Eddy Patrick Rugeramigabo, Rolf J. Haug, Jingzhong Yang, Michael Zopf

“…We envisage that such implementations facilitate the heterogeneous integration of quantum photonic devices, integrating both solid-state quantum light sources and memories by adapting their characteristics.…”
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Diagnostic and prognostic value of serum hepcidin concentration in patients with acute spontaneous supratentorial intracerebral hemorrhage by O. А. Koziolkin, A. A. Kuznietsov

“…Hepcidin levels, serum iron concentrations and total iron-binding capacity were determined, followed by calculations of transferrin saturation coefficient. …”
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Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions by Wenhua Liu, Na Li, Dongsheng Tang, Lang Qin, Zhiqiang Zhu

“…Neuroimaging biomarkers (e.g., striatal PET-dopamine binding potential) predict intervention outcomes (AUC = 0.79). 3. …”
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The Mechanism of “Treating Different Diseases with the Same Treatment” by Qiangji Jianpi Decoction in Ankylosing Spondylitis Combined with Inflammatory Bowel Disease: A Comprehensi... by Xuhong Zhang, Lamei Zhou, Xian Qian

“…These targets predominantly participate in organismal responses and DNA transcription factor binding, with a significant cellular presence in the endoplasmic reticulum and vesicle lumen. …”
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PROBLEMS OF FORMATION OF FINANCIAL-INVESTMENT PROJECTION OF A BALANCED SCORECARD IN VALUE-BASED ENTERPRISES OF MINING-METALLURGICAL COMPLEX by S. Faizova, M. Ivanova, S. Sannikova, O. Varyanichenko

“…The necessity and the possibility of integration of VBM and BSC concepts, which may be implemented through the company’s financial control panel by using VBM metrics, has been substantiated. …”
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Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization by Zilong Chen, Quan Wang, Lianqin Zhang, Junfeng Qiu, Yangling Zeng, Hao Kuang, Chunxiu Chen, Zhiming Hong

“…Finally, molecular docking indicated strong binding affinities between these candidate drugs and the protein encoded by TGFBR2 (Vina score < −50). …”
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REVIEW ON PROTEIN FOOTPRINTING AS A TOOL IN STRUCTURAL BIOLOGY by Oluwatosin Ogundairo, Oluwatoyin Ayo-Farai, Chinedu Paschal Maduka, Chiamaka Chinaemelum Okongwu, Abdulraheem Olaide Babarinde, Olamide Sodamade

“…The application of protein footprinting in studying protein-protein interactions, ligand binding, and conformational changes is highlighted through a detailed examination of key studies and experimental approaches. …”
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions by Ping Jin, Xirui Duan, Zhao Huang, Yuan Dong, Jianmei Zhu, Huiming Guo, Hui Tian, Cheng-Gang Zou, Ke Xie

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Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction by Wudmir Y. Rojas, Zargham Ahmad, Julia Jakiela, Helge Hecht, Jana Klánová, Elliott J. Price

“…Here, we provide a robust workflow that leverages interoperable file formats for molecular structures to ensure integration across various QC tools. The quantum chemistry package for mass spectral predictions after electron ionization or collision-induced dissociation has been integrated into the Galaxy platform, enabling automated analysis of fragmentation mechanisms. …”
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A novel hyperactive variant of the Sleeping Beauty transposase facilitates non-viral genome engineering by Matthias Thomas Ochmann, Csaba Miskey, Lacramioara Botezatu, Nicolás Sandoval-Villegas, Tanja Diem, Zoltán Ivics

“…Position 124 is located at the very edge of the linker region that connects the DNA-binding and catalytic domains of the transposase. …”
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Functional characterization of SOX5 variant causing Lamb–Shaffer syndrome and literature review of variants in the SOX5 gene by Ping Wang, Hanbing Xie, Xiao Xiao, He Wang, Yan Wang, Shanling Liu

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