Assessing Policy Consistency and Synergy in China’s Water–Energy–Land–Food Nexus for Low-Carbon Transition by Xiaonan Zhu, Cheng Zhou, Clare Richardson-Barlow

“…The need for integrated governance of water–energy–land–food (WELF) systems has become paramount in achieving sustainable low-carbon transitions, yet policy consistency across these interdependent sectors remains critically underexplored. …”
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On the origin of non-specific binders isolated in the selection of phage display peptide libraries by Babak Bakhshinejad, Babak Bakhshinejad, Andreas Kjaer, Andreas Kjaer

“…The most significant drawback of phage display is the undesirable enrichment and isolation of phages whose displayed peptides have no binding affinity toward the target. Phages with high amplification rates constitute the most important category of non-specific binders. …”
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Cellulophaga algicola alginate lyase and Pseudomonas aeruginosa Psl glycoside hydrolase inhibit biofilm formation by Pseudomonas aeruginosa CF2843 on three-dimensional aggregates o... by Neetu, Shilpee Pal, Srikrishna Subramanian, T.N.C. Ramya

“…Immunostaining and lectin binding studies indicated that the three-dimensional cell aggregates harbored sialylated and fucosylated epitopes as well as Muc1, Muc5Ac, and β-catenin on their surfaces, suggestive of mucin secretion and the presence of tight junctions, hallmark features of lung epithelial tissue. …”
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Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…Furthermore, the integration of CRISPR-Cas9 with omics technologies, including transcriptomics, proteomics, and lipidomics, has unlocked new avenues for identifying previously unknown genetic players and pathways involved in fertilization. …”
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A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare by Yifeng Ding, Liuhong Yang, Jing Wen, Yuhang Ma, Ge Dai, Fengfeng Mo, Jiafeng Wang

“…Future research should aim to improve sensor design, biocompatibility, and integration with advanced signal processing techniques. …”
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Translational PK–PD model for in vivo CAR‐T‐cell therapy delivered using CAR mRNA‐loaded polymeric nanoparticle vector by Se Jin Kim, Ganesh M. Mugundu, Aman P. Singh

“…This mechanistic PK–PD model holds potential for integration into physiologically‐based pharmacokinetic models, facilitating the translation of in vivo CAR‐T‐cell therapies from preclinical studies to human applications.…”
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Prediction of secreted uncharacterized protein structures from Beauveria bassiana ARSEF 2860 unravels novel toxins-like families by Peter F. Farag, Aya A. Elsisi, Esraa W. Elabd, Jana J. Sadek, Nada H. Mousa, Rawan M. Zaky, Sara M. Ahmed

“…We implemented the integration of well-designed bioinformatic tools to characterize and anticipate their homologous similarities at the sequence (InterPro) and structural (AlphaFold2) levels. …”
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Machine learning-driven multi-targeted drug discovery in colon cancer using biomarker signatures by Tingting Liu, Lifan Zhong, Xizhe Sun, Zhijiang He, Witiao Lv, Liyun Deng, Yanfei Chen

“…The CatBoost algorithm efficiently classifies patients based on molecular profiles and predicts drug responses. The ABF-CatBoost integration facilitates a multi-targeted therapeutic approach, addressing drug resistance by analyzing mutation patterns, adaptive resistance mechanisms, and conserved binding sites. …”
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Predicting prognosis and immunotherapy response of ferroptosis-related genes in colorectal cancer by Hongyun Wei, Keyu Ren, Yanchun Jin, Yao Wen, Bin Cao, Yu Gan, Ying Shi, Zhihong Wu, Linlin Chen

“…Abstract To identify ferroptosis markers, which were associated with prognosis and immune response in colorectal cancer (CRC), we integrated spatial transcriptome, single-cell transcriptome, and bulk transcriptome data for analysis, and this multi-omics integration approach is an innovation that distinguishes this study from previous ones. …”
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Targeting programmed death ligand 1 for anticancer therapy using computational drug repurposing and molecular simulations by Mohd Shahnawaz Khan, Anas Shamsi, Moyad Shahwan, Khuzin Dinislam, Dharmendra Kumar Yadav

“…The simulations revealed sustained structural integrity and stable binding of both complexes throughout the 500 ns trajectories, supporting their potential as PD-L1 inhibitors. …”
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CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells by Shufeng Liu, Xiaoguang Chen, Liqi Zhang, Bo Lu

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AI designed, mutation resistant broad neutralizing antibodies against multiple SARS-CoV-2 strains by Yue Kang, Kevin Jin, Lurong Pan

“…Abstract In this study, we developed a digital twin for SARS-CoV-2 by integrating diverse data and metadata with multiple data types and processing strategies, including machine learning, natural language processing, protein structural modeling, and protein sequence language modeling. …”
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Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines by Guy de Bruyn, Haritha Adhikarla, Caroline K. Brackett, Yichen Jia, Premkumar Lakshmanane, Sarah V. Mudrak, Sheetal Sawant, Donghui Zhang, Roman M. Chicz, Saranya Sridhar, Georgia D. Tomaras, Kelly E. Seaton

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Middle sentences: An argument for conceptual structure by Luis Manuel Estudillo Díaz

“…Middle sentences in English are only partly described within the Government and Binding theory. Some semantic and discourse generalizations which are integral to the meaning of these constructions are just set aside, if they are mentioned at all. …”
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein by Ziqi Feng, Jiachen Huang, Sabyasachi Baboo, Jolene K. Diedrich, Sandhya Bangaru, James C. Paulson, John R. Yates, III, Meng Yuan, Ian A. Wilson, Andrew B. Ward

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Site-wise dynamic defects in a non-conserving exclusion process by Nikhil Bhatia, Arvind Kumar Gupta

“…Our approach streamlines the defect dynamics by integrating two parameters into one called the obstruction factor, which helps in determining an effective binding constant. …”
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Two independent regulatory mechanisms synergistically contribute to P450-mediated insecticide resistance in a lepidopteran pest, Spodoptera exigua by Bo Hu, Yuting Zhang, Zhiping Xing, Xiangzhu Chen, Cong Rao, Kuitun Liu, Anjiang Tan, Jianya Su

“…Reporter gene assays and site-directed mutagenesis analyses confirm that a specific binding site is crucial for binding CncC/Maf to activate the expression of CYP321B1. …”
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In-silico based discovery of potential Keap1 inhibitors using the strategies of pharmacophore screening, molecular docking, and MD simulation studies by Ekta Singh, Gurubasavaraja Swamy Purawarga Matada, Prasad Sanjay Dhiwar, Rajesh B. Patil, Rohit Pal

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Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme–ligand complexes by O. Vavra, J. Tyzack, F. Haddadi, J. Stourac, J. Damborsky, S. Mazurenko, J. M. Thornton, D. Bednar

“…Analysis of ligand un/binding energetics indicates that the top priority tunnel has the most favourable energies in 75% of cases. …”
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Chemical profiling and mechanistic insights into the antibacterial efficacy of Melaleuca cajuputi leaf extract by Musa Isah, Mohd Dasuki Sul’ain, Wan-Nor-Amilah Wan Abdul Wahab, Hasmah Abdullah, Shajarahtunnur Jamil, Nordina Syamira, Mahamad Shabudin, Ahmad Naqib Shuid, Wan Rosli Wan Ishak

“…The binding energy scores for these interactions varied between − 6.0 kcal/mol and − 7.5 kcal/mol. …”
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