Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1. by Ossie F Dyson, Lia R Walker, Adrian Whitehouse, Paul P Cook, Shaw M Akula

“…In here, electrophoretic mobility shift assays (EMSA) and chromatin immunoprecipitation (ChIP) experiments revealed that Egr-1 binds KSHV ORF50 promoter (ORF50P) in at least two different GC-rich binding domains. …”
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Single cell variability of CRISPR‐Cas interference and adaptation by Rebecca E McKenzie, Emma M Keizer, Jochem N A Vink, Jasper van Lopik, Ferhat Büke, Vera Kalkman, Christian Fleck, Sander J Tans, Stan J J Brouns

“…Our findings suggest that Cascade binding to the mutated invader DNA, rather than spacer integration, is the main source of priming heterogeneity. …”
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Selection and optimization of a unified protocol for transmitting measurement results in information and measurement systems with adaptive settings by Yu.O. Podchashynskyi, O.S. Ishchenko

“…An analysis of existing data transfer protocols, from outdated to modern ones, was performed, with an emphasis on their ability to ensure efficiency and a high level of integral reliability of measurement information transfer. …”
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Emergent 2D van der Waals materials photonic sources by Tang Kwok Kwan, Li Chun, Zhu Changhai, Li Peipei, Zhao Liyun, Zhang Qing

“…Over the past two decades, two-dimensional (2D) van der Waals (vdW) semiconductors have garnered significant attention in the field of light sources due to their unique optoelectronic properties, such as high excitonic binding energy, tunable bandgaps, and strong optical anisotropy. …”
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Recent Advances in Enzymatic Biofuel Cells to Power Up Wearable and Implantable Biosensors by Zina Fredj, Guoguang Rong, Mohamad Sawan

“…A critical assessment of enzyme immobilization techniques, including physical adsorption, covalent binding, entrapment, and cross-linking, underscores the importance of optimizing enzyme stability and catalytic activity for enhanced bioelectrode performance. …”
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BSMD-YOLOv8: Enhancing YOLOv8 for Book Signature Marks Detection by Long Guo, Lubin Wang, Qiang Yu, Xiaolan Xie

“…In the field of bookbinding, accurately and efficiently detecting signature sequences during the binding process is crucial for enhancing quality, improving production efficiency, and advancing industrial automation. …”
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Drebrin regulates neuroblast migration in the postnatal mammalian brain. by Martina Sonego, Michelle Oberoi, Jake Stoddart, Sangeetha Gajendra, Rita Hendricusdottir, Fazal Oozeer, Daniel C Worth, Carl Hobbs, Britta J Eickholt, Phillip R Gordon-Weeks, Patrick Doherty, Giovanna Lalli

“…Here, we have investigated the function of drebrin, an actin-binding protein highly expressed in the RMS of the postnatal mammalian brain. …”
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Roles of nanomagnetic beads on biosensing: From fabrication to application by Junjie Li, Liyang Duan, Qian Chen, Songsong Huang, Weixia Li, Huachu Zuo, Shuang Li, Wei Han, Wei Fu, Shike Hou, Bin Fan, Zetao Chen

“…With the modification of recognition components, nanomagnetic beads can function by specifically binding target analytes, serving as sensitive elements for biosensing. …”
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SlimPort: Port-Driven High-Level Synthesis for Continuous-Flow Microfluidic Biochips by Youlin Pan, Yanbo Xu, Ziyang Chen, Xing Huang, Genggeng Liu

“…Increasing the number of fluidic ports undermines the integration, reduces the reliability, and increases the manufacturing cost. …”
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Centrifugation-assisted lateral flow assay platform: enhancing bioassay sensitivity with active flow control by Hang Yuan, Ruiqi Yong, Wenwen Yuan, Quan Zhang, Eng Gee Lim, Yongjie Wang, Fuzhou Niu, Pengfei Song

“…An alternative approach is to actively regulate fluid dynamics to optimize analyte binding and signal generation. The key challenge is to enhance LFA sensitivity while preserving compatibility with existing lateral flow strips (LFSs). …”
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Sophorolipids as anticancer agents: progress and challenges by Salam Bhopen Singh, Kanupriya Kuniyal, Ananya Rawat, Ananya Bisht, Vijendra Shah, Achlesh Daverey

“…Their mechanism of action targets apoptosis and operates at the level of caspase enzymes, upregulation and downregulation of the B-cell lymphoma (Bcl)-family proteins, and changes in mitochondrial membrane permeability. The binding of SLs to the cancer cell receptors modulates the expression of Bax, APAF1, Bcl-2 and Bcl-x, and triggers the release of cytochrome c into the cytosol which further activates caspase-3/9 pathways leading to apoptosis. …”
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A deep learning and molecular modeling approach to repurposing Cangrelor as a potential inhibitor of Nipah virus by Levin John, Leona Dcunha, Mukhtar Ahmed, Sonet Daniel Thomas, Rajesh Raju, Abhithaj Jayanandan

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Ultrasensitive Bead-Based Immunoassay for Real-Time Continuous Sample Flow Analysis by Yuri M. Shlyapnikov, Elena A. Shlyapnikova

“…However, at low analyte concentrations, the binding rate is still low. Here, we demonstrate a further improvement of analyte binding kinetics in bead-based immunoassays by simultaneously concentrating both an analyte and magnetic beads in a compact spatial region where binding occurs. …”
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Design and screening of novel 1,2,4-Triazole-3-thione derivatives as DCN1 inhibitors for anticardiac fibrosis based on 3D-QSAR modeling and molecular dynamics by Wengong Bian, Yaxin Guo

“…The top compound exhibited a predicted pIC50 of 9.674 and showed strong binding affinity in molecular docking. Molecular dynamics simulations confirmed the stability of the compound at the binding site, while energy decomposition analysis identified key residues essential for binding interaction.ConclusionThis study successfully designed and evaluated novel DCN1 inhibitors using an integrated approach that combines 3D-QSAR modeling, molecular docking, and molecular dynamics simulations. …”
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ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS

“…We applied NIR-FLI-FRET to quantify HER2 binding in HER2+ breast cancer cells, tumor spheroids, and xenografts. …”
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Combining Experimental and Computational Tools to Unravel Copper-Based Metallodrug Interactions With Proteins by Quim Peña, Iker Zapirain-Gysling, A. Jalila Simaan, Mercè Capdevila, Olga Iranzo, Òscar Palacios, Jean-Didier Maréchal, Pau Bayón

“…Further insights into the preferential modes of binding were evaluated by density functional theory and docking calculations, which revealed three main outer surface binding sites for both albumin and myoglobin, as well as three preferential inner pockets in the case of albumin. …”
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Computational molecular insights into ibrutinib as a potent inhibitor of HER2-L755S mutant in breast cancer: gene expression studies, virtual screening, docking, and molecular dyna... by Tamizhini Loganathan, C. George Priya Doss

“…Detailed docking and molecular dynamics simulations in the bound (Holo) state demonstrated that the HER2-L755S-ibrutinib complex exhibited higher binding affinity and lower binding energy, indicating more stable interactions compared to other complexes. …”
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Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule by Si-Min Shao, Xuan Ji, Xing Wang, Run-Zhou Liu, Yu-Ru Cai, Xiaobing Lin, Ze-Jie Zeng, Ling Chen, Liu Yang, Hua Yang, Wen Gao

“…Furthermore, all 24 screened compounds exhibit strong binding affinities with FOXO3 evaluated by molecular docking. …”
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Repurposing of apoptotic inducer drugs against Mycobacterium tuberculosis by Kudakwashe Nyambo, Vivette Soko, Kudzanai Ian Tapfuma, Bongani Motaung, Francis Adu-Amankwaah, Lauren Julius, Ashwil Klein, Marshall Keyster, Lucinda Baatjies, Liezel Smith, Krishna Kuben Govender, Mkhuseli Ngxande, Andre G. Loxton, Vuyo Mavumengwana

“…The immunomodulatory potential of the apoptotic compounds was determined on mycobacterial-infected THP-1 and non-infected THP-1 macrophage cells. The potential binding dynamics of the compounds against InhA were predicted using molecular docking, molecular dynamics, and MM-GBSA binding free energies. …”
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Evaluating protein complexes between human aquaporin and calmodulin using biomolecular fluorescence complementation by Jessica Glas, Johanna Landén, Kristina Hedfalk

“…Abstract Aquaporins (AQPs) are a family of integral membrane proteins crucial for the flow of water and other small molecules across cellular membranes. …”
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